| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BVF INC/IL | 1,775,572 | 12,411,000 | 31.08% | ||
| 2 | Capital World Investors | 1,030,000 | 7,200,000 | 18.03% | ||
| 3 | ROYAL BANK OF CANADA | 468,003 | 3,272,000 | 8.19% | ||
| 4 | Invesco Private Capital, Inc. | 436,384 | 3,050,000 | 7.64% | ||
| 5 | Visium Asset Management, LP | 420,000 | 2,936,000 | 7.35% | ||
| 6 | Opaleye Management Inc. | 400,000 | 2,796,000 | 7.00% | ||
| 7 | Point72 Asset Management, L.P. | 358,531 | 2,506,000 | 6.28% | ||
| 8 | PERCEPTIVE ADVISORS LLC | 205,800 | 1,438,000 | 3.60% | ||
| 9 | DAFNA Capital Management LLC | 193,195 | 1,350,000 | 3.38% | ||
| 10 | Novo Holdings A/S | 127,563 | 892,000 | 2.23% | ||
| 11 | JBF Capital, Inc. | 68,690 | 480,000 | 1.20% | ||
| 12 | State of New Jersey Common Pension Fund D | 65,000 | 454,000 | 1.14% | ||
| 13 | Weiss Multi-Strategy Advisers LLC | 51,000 | 356,000 | 0.89% | ||
| 14 | RENAISSANCE TECHNOLOGIES LLC | 33,800 | 236,000 | 0.59% | ||
| 15 | LEITH WHEELER INVESTMENT COUNSEL LTD. | 16,075 | 146,000 | 0.37% | ||
| 16 | NJ State Employees Deferred Compensation Plan | 20,000 | 143,000 | 0.36% | ||
| 17 | GSA CAPITAL PARTNERS LLP | 13,384 | 94,000 | 0.24% | ||
| 18 | DEUTSCHE BANK AG\ | 7,616 | 53,000 | 0.13% | ||
| 19 | BANK OF MONTREAL /CAN/ | 7,137 | 50,000 | 0.13% | ||
| 20 | WELLS FARGO & COMPANY/MN | 4,925 | 34,000 | 0.09% | ||
| 21 | Tower Research Capital LLC (TRC) | 2,344 | 17,000 | 0.04% | ||
| 22 | UBS Group AG | 1,106 | 8,000 | 0.02% | ||
| 23 | MORGAN STANLEY | 917 | 6,000 | 0.02% | ||
| 24 | CITIGROUP INC | 700 | 5,000 | 0.01% | ||
| 25 | Walleye Trading LLC | 300 | 2,000 | 0.01% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
