| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BVF INC/IL | 3,108,905 | 25,182,000 | 31.25% | ||
| 2 | Capital World Investors | 1,030,000 | 8,343,000 | 10.35% | ||
| 3 | ORBIMED ADVISORS LLC | 1,000,000 | 8,100,000 | 10.05% | ||
| 4 | PERCEPTIVE ADVISORS LLC | 762,800 | 6,179,000 | 7.67% | ||
| 5 | Tekla Capital Management LLC | 700,000 | 5,670,000 | 7.04% | ||
| 6 | DAFNA Capital Management LLC | 514,091 | 4,164,000 | 5.17% | ||
| 7 | Invesco Private Capital, Inc. | 412,479 | 3,341,000 | 4.15% | ||
| 8 | Opaleye Management Inc. | 410,000 | 3,321,000 | 4.12% | ||
| 9 | ROYAL BANK OF CANADA | 367,311 | 2,975,000 | 3.69% | ||
| 10 | Point72 Asset Management, L.P. | 358,531 | 2,904,000 | 3.60% | ||
| 11 | Ghost Tree Capital, LLC | 325,000 | 2,633,000 | 3.27% | ||
| 12 | HIGHLAND CAPITAL MANAGEMENT LP | 250,000 | 2,025,000 | 2.51% | ||
| 13 | SPHERA FUNDS MANAGEMENT LTD. | 228,029 | 1,847,000 | 2.29% | ||
| 14 | Novo Holdings A/S | 127,563 | 1,033,000 | 1.28% | ||
| 15 | RENAISSANCE TECHNOLOGIES LLC | 96,200 | 779,000 | 0.97% | ||
| 16 | State of New Jersey Common Pension Fund D | 65,000 | 527,000 | 0.65% | ||
| 17 | Weiss Multi-Strategy Advisers LLC | 31,500 | 255,000 | 0.32% | ||
| 18 | DEUTSCHE BANK AG\ | 28,748 | 232,000 | 0.29% | ||
| 19 | MONASHEE INVESTMENT MANAGEMENT LLC | 25,000 | 203,000 | 0.25% | PRN | |
| 20 | LEITH WHEELER INVESTMENT COUNSEL LTD. | 16,075 | 171,000 | 0.21% | ||
| 21 | SCOTIA CAPITAL INC. | 20,820 | 169,000 | 0.21% | ||
| 22 | NJ State Employees Deferred Compensation Plan | 20,000 | 162,000 | 0.20% | ||
| 23 | K2 PRINCIPAL FUND, L.P. | 15,000 | 122,000 | 0.15% | ||
| 24 | M&T BANK CORP | 14,251 | 115,000 | 0.14% | ||
| 25 | BANK OF MONTREAL /CAN/ | 7,137 | 58,000 | 0.07% | ||
| 26 | MORGAN STANLEY | 2,811 | 23,000 | 0.03% | ||
| 27 | WELLS FARGO & COMPANY/MN | 2,464 | 20,000 | 0.02% | ||
| 28 | JPMORGAN CHASE & CO | 1,700 | 14,000 | 0.02% | ||
| 29 | Tower Research Capital LLC (TRC) | 997 | 8,000 | 0.01% | ||
| 30 | CITIGROUP INC | 700 | 6,000 | 0.01% | ||
| 31 | UBS Group AG | 617 | 5,000 | 0.01% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
