| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 4,511,515 | 117,931,000 | 19.65% | ||
| 2 | Bain Capital Public Equity Management, LLC | 2,862,025 | 74,813,000 | 12.47% | ||
| 3 | CREDIT SUISSE AG/ | 2,268,899 | 59,309,000 | 9.88% | ||
| 4 | WELLINGTON MANAGEMENT GROUP LLP | 1,457,157 | 38,090,000 | 6.35% | ||
| 5 | RA CAPITAL MANAGEMENT, L.P. | 981,761 | 25,663,000 | 4.28% | ||
| 6 | SECTORAL ASSET MANAGEMENT INC | 947,902 | 24,778,000 | 4.13% | ||
| 7 | Granahan Investment Management, LLC | 901,423 | 23,563,000 | 3.93% | ||
| 8 | JENNISON ASSOCIATES LLC | 861,826 | 22,528,000 | 3.75% | ||
| 9 | ORBIMED ADVISORS LLC | 830,100 | 21,699,000 | 3.62% | ||
| 10 | STATE STREET CORP | 693,456 | 18,129,000 | 3.02% | ||
| 11 | BlackRock Fund Advisors | 675,013 | 17,645,000 | 2.94% | ||
| 12 | PERCEPTIVE ADVISORS LLC | 671,736 | 17,558,000 | 2.93% | ||
| 13 | JANUS HENDERSON INVESTORS US LLC | 610,421 | 15,956,000 | 2.66% | ||
| 14 | Cormorant Asset Management, LP | 550,000 | 14,377,000 | 2.40% | ||
| 15 | WESTFIELD CAPITAL MANAGEMENT CO LP | 491,140 | 12,838,000 | 2.14% | ||
| 16 | LOOMIS SAYLES & CO L P | 473,215 | 12,369,000 | 2.06% | ||
| 17 | VANGUARD GROUP INC | 465,955 | 12,180,000 | 2.03% | ||
| 18 | FRANKLIN RESOURCES INC | 397,800 | 10,398,000 | 1.73% | ||
| 19 | DEERFIELD MANAGEMENT COMPANY, L.P. | 317,530 | 8,300,000 | 1.38% | ||
| 20 | Numeric Investors LLC | 251,282 | 6,569,000 | 1.09% | ||
| 21 | PUTNAM INVESTMENTS LLC | 220,100 | 5,753,000 | 0.96% | ||
| 22 | NORTHERN TRUST CORP | 150,010 | 3,921,000 | 0.65% | ||
| 23 | BlackRock Institutional Trust Company, N.A. | 140,595 | 3,675,000 | 0.61% | ||
| 24 | CITADEL ADVISORS LLC | 122,692 | 3,206,000 | 0.53% | ||
| 25 | GEODE CAPITAL MANAGEMENT, LLC | 99,894 | 2,611,000 | 0.44% | ||
| 26 | UNITED SERVICES AUTOMOBILE ASSOCIATION | 91,937 | 2,403,000 | 0.40% | ||
| 27 | BLACKROCK ADVISORS LLC | 81,429 | 2,129,000 | 0.35% | ||
| 28 | Tekla Capital Management LLC | 79,150 | 2,069,000 | 0.34% | ||
| 29 | Invesco Ltd. | 77,562 | 2,027,000 | 0.34% | ||
| 30 | TOCQUEVILLE ASSET MANAGEMENT L.P. | 74,500 | 1,947,000 | 0.32% | ||
| 31 | CITY NATIONAL BANK | 67,605 | 1,767,000 | 0.29% | ||
| 32 | PICTET ASSET MANAGEMENT LTD | 59,400 | 1,553,000 | 0.26% | ||
| 33 | Bank of New York Mellon Corp | 53,120 | 1,389,000 | 0.23% | ||
| 34 | TIAA CREF INVESTMENT MANAGEMENT LLC | 39,918 | 1,043,000 | 0.17% | ||
| 35 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 34,786 | 910,000 | 0.15% | ||
| 36 | ProShare Advisors LLC | 33,988 | 888,000 | 0.15% | ||
| 37 | BlackRock Investment Management, LLC | 32,462 | 849,000 | 0.14% | ||
| 38 | BlackRock Group LTD | 31,171 | 815,000 | 0.14% | ||
| 39 | DEUTSCHE BANK AG\ | 25,377 | 662,000 | 0.11% | ||
| 40 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 20,600 | 538,000 | 0.09% | ||
| 41 | GAM Holding AG | 20,200 | 528,000 | 0.09% | ||
| 42 | Swiss National Bank | 19,820 | 518,000 | 0.09% | ||
| 43 | TEACHERS ADVISORS, LLC | 16,650 | 435,000 | 0.07% | ||
| 44 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 16,251 | 425,000 | 0.07% | ||
| 45 | BLUE ARROW CAPITAL MANAGEMENT LLC | 16,000 | 418,000 | 0.07% | ||
| 46 | MORGAN STANLEY | 12,654 | 331,000 | 0.06% | ||
| 47 | METROPOLITAN LIFE INSURANCE CO/NY | 11,005 | 288,000 | 0.05% | ||
| 48 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 9,757 | 255,000 | 0.04% | ||
| 49 | TFS CAPITAL LLC | 9,289 | 243,000 | 0.04% | ||
| 50 | ROYAL BANK OF CANADA | 9,025 | 236,000 | 0.04% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
