| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | WELLINGTON MANAGEMENT GROUP LLP | 4,598,539 | 32,282,000 | 15.70% | ||
| 2 | VANGUARD GROUP INC | 2,329,802 | 16,355,000 | 7.95% | ||
| 3 | PICTET ASSET MANAGEMENT LTD | 1,329,215 | 10,846,000 | 5.27% | ||
| 4 | Camber Capital Management LP | 1,500,000 | 10,530,000 | 5.12% | ||
| 5 | FRONTIER CAPITAL MANAGEMENT CO LLC | 1,433,975 | 10,067,000 | 4.90% | ||
| 6 | TOCQUEVILLE ASSET MANAGEMENT L.P. | 1,400,643 | 9,833,000 | 4.78% | ||
| 7 | BlackRock Fund Advisors | 1,299,528 | 9,123,000 | 4.44% | ||
| 8 | BB BIOTECH AG | 1,182,912 | 8,304,000 | 4.04% | ||
| 9 | FMR LLC | 1,136,211 | 7,976,000 | 3.88% | ||
| 10 | BlackRock Institutional Trust Company, N.A. | 812,757 | 5,706,000 | 2.78% | ||
| 11 | BLACKROCK ADVISORS LLC | 742,711 | 5,214,000 | 2.54% | ||
| 12 | SECTORAL ASSET MANAGEMENT INC | 648,976 | 4,556,000 | 2.22% | ||
| 13 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 615,531 | 4,321,000 | 2.10% | ||
| 14 | STATE STREET CORP | 582,348 | 4,091,000 | 1.99% | ||
| 15 | BANK OF AMERICA CORP /DE/ | 503,119 | 3,532,000 | 1.72% | ||
| 16 | NORTHERN TRUST CORP | 456,607 | 3,205,000 | 1.56% | ||
| 17 | JENNISON ASSOCIATES LLC | 446,000 | 3,131,000 | 1.52% | ||
| 18 | AMERIPRISE FINANCIAL INC | 399,168 | 2,803,000 | 1.36% | ||
| 19 | FRANKLIN RESOURCES INC | 397,800 | 2,793,000 | 1.36% | ||
| 20 | PINNACLE ASSOCIATES LTD | 387,639 | 2,721,000 | 1.32% | ||
| 21 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 350,000 | 2,457,000 | 1.19% | ||
| 22 | JPMORGAN CHASE & CO | 345,941 | 2,428,000 | 1.18% | ||
| 23 | Granite Point Capital Management, L.P. | 327,579 | 2,300,000 | 1.12% | ||
| 24 | ASYMMETRY CAPITAL MANAGEMENT, L.P. | 306,650 | 2,153,000 | 1.05% | ||
| 25 | BOGLE INVESTMENT MANAGEMENT L P /DE/ | 257,679 | 1,808,000 | 0.88% | ||
| 26 | GEODE CAPITAL MANAGEMENT, LLC | 225,753 | 1,584,000 | 0.77% | ||
| 27 | PUTNAM INVESTMENTS LLC | 220,000 | 1,544,000 | 0.75% | ||
| 28 | QS Investors, LLC | 219,206 | 1,539,000 | 0.75% | ||
| 29 | BlackRock Group LTD | 202,283 | 1,420,000 | 0.69% | ||
| 30 | South Dakota Investment Council | 198,800 | 1,396,000 | 0.68% | ||
| 31 | BlackRock Investment Management, LLC | 183,317 | 1,287,000 | 0.63% | ||
| 32 | SPHERA FUNDS MANAGEMENT LTD. | 174,461 | 1,225,000 | 0.60% | ||
| 33 | DEUTSCHE BANK AG\ | 168,877 | 1,183,000 | 0.58% | ||
| 34 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 166,800 | 1,171,000 | 0.57% | Call | |
| 35 | TWO SIGMA ADVISERS, LP | 161,100 | 1,131,000 | 0.55% | ||
| 36 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 156,400 | 1,098,000 | 0.53% | Put | |
| 37 | Telemetry Investments, L.L.C. | 153,600 | 1,078,000 | 0.52% | Call | |
| 38 | Bank of New York Mellon Corp | 150,068 | 1,053,000 | 0.51% | ||
| 39 | A.R.T. Advisors, LLC | 149,159 | 1,047,000 | 0.51% | ||
| 40 | MACKENZIE FINANCIAL CORP | 138,200 | 970,000 | 0.47% | ||
| 41 | TIAA CREF INVESTMENT MANAGEMENT LLC | 131,424 | 923,000 | 0.45% | ||
| 42 | Numeric Investors LLC | 126,400 | 887,000 | 0.43% | ||
| 43 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 104,188 | 731,000 | 0.36% | ||
| 44 | RENAISSANCE TECHNOLOGIES LLC | 101,900 | 715,000 | 0.35% | ||
| 45 | DIMENSIONAL FUND ADVISORS LP | 100,783 | 707,000 | 0.34% | ||
| 46 | Fisher Asset Management, LLC | 89,642 | 670,000 | 0.33% | ||
| 47 | OPPENHEIMER & CO INC | 87,456 | 613,000 | 0.30% | ||
| 48 | DAVENPORT & Co LLC | 82,200 | 577,044 | 0.28% | ||
| 49 | ALLIANCEBERNSTEIN L.P. | 75,650 | 531,000 | 0.26% | ||
| 50 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 69,741 | 490,000 | 0.24% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
