| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | WELLINGTON MANAGEMENT GROUP LLP | 3,556,626 | 38,804,000 | 12.00% | ||
| 2 | VANGUARD GROUP INC | 1,918,708 | 20,934,000 | 6.48% | ||
| 3 | BlackRock Fund Advisors | 1,567,925 | 17,106,000 | 5.29% | ||
| 4 | MILLENNIUM MANAGEMENT LLC | 1,535,567 | 16,753,000 | 5.18% | ||
| 5 | D. E. Shaw & Co., Inc. | 1,502,912 | 16,397,000 | 5.07% | ||
| 6 | FRONTIER CAPITAL MANAGEMENT CO LLC | 1,369,737 | 14,944,000 | 4.62% | ||
| 7 | RTW INVESTMENTS, LP | 997,166 | 10,879,000 | 3.37% | ||
| 8 | BlackRock Institutional Trust Company, N.A. | 983,090 | 10,726,000 | 3.32% | ||
| 9 | TOCQUEVILLE ASSET MANAGEMENT L.P. | 785,975 | 8,575,000 | 2.65% | ||
| 10 | BOGLE INVESTMENT MANAGEMENT L P /DE/ | 756,488 | 8,253,000 | 2.55% | ||
| 11 | FMR LLC | 732,044 | 7,987,000 | 2.47% | ||
| 12 | BB BIOTECH AG | 682,912 | 7,451,000 | 2.31% | ||
| 13 | JPMORGAN CHASE & CO | 620,075 | 6,765,000 | 2.09% | ||
| 14 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 605,000 | 6,601,000 | 2.04% | ||
| 15 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 600,612 | 6,553,000 | 2.03% | ||
| 16 | STATE STREET CORP | 594,396 | 6,483,000 | 2.01% | ||
| 17 | Numeric Investors LLC | 568,319 | 6,200,000 | 1.92% | ||
| 18 | NORTHERN TRUST CORP | 563,557 | 6,149,000 | 1.90% | ||
| 19 | BANK OF AMERICA CORP /DE/ | 524,023 | 5,717,000 | 1.77% | ||
| 20 | ASYMMETRY CAPITAL MANAGEMENT, L.P. | 484,579 | 5,287,000 | 1.64% | ||
| 21 | BLACKROCK ADVISORS LLC | 443,917 | 4,843,000 | 1.50% | ||
| 22 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 435,600 | 4,752,000 | 1.47% | Call | |
| 23 | DEUTSCHE BANK AG\ | 403,090 | 4,395,000 | 1.36% | ||
| 24 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 381,600 | 4,163,000 | 1.29% | Put | |
| 25 | PINNACLE ASSOCIATES LTD | 351,422 | 3,834,000 | 1.19% | ||
| 26 | DIMENSIONAL FUND ADVISORS LP | 312,460 | 3,409,000 | 1.05% | ||
| 27 | MORGAN STANLEY | 295,103 | 3,219,000 | 1.00% | ||
| 28 | TEACHERS ADVISORS, LLC | 275,371 | 3,004,000 | 0.93% | ||
| 29 | GEODE CAPITAL MANAGEMENT, LLC | 259,306 | 2,829,000 | 0.88% | ||
| 30 | AMERIPRISE FINANCIAL INC | 259,023 | 2,826,000 | 0.87% | ||
| 31 | QS Investors, LLC | 225,367 | 2,459,000 | 0.76% | ||
| 32 | ORBIMED ADVISORS LLC | 204,400 | 2,230,000 | 0.69% | ||
| 33 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 200,000 | 2,182,000 | 0.68% | Call | |
| 34 | South Dakota Investment Council | 181,411 | 1,979,000 | 0.61% | ||
| 35 | PRELUDE CAPITAL MANAGEMENT, LLC | 181,024 | 1,975,000 | 0.61% | ||
| 36 | BlackRock Investment Management, LLC | 162,274 | 1,770,000 | 0.55% | ||
| 37 | Bank of New York Mellon Corp | 161,925 | 1,766,000 | 0.55% | ||
| 38 | PDT Partners, LLC | 161,100 | 1,758,000 | 0.54% | ||
| 39 | SPHERA FUNDS MANAGEMENT LTD. | 150,000 | 1,637,000 | 0.51% | ||
| 40 | C WorldWide Group Holding A/S | 145,322 | 1,585,000 | 0.49% | ||
| 41 | OXFORD ASSET MANAGEMENT LLP | 136,592 | 1,490,000 | 0.46% | ||
| 42 | BlackRock Group LTD | 134,470 | 1,466,000 | 0.45% | ||
| 43 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 131,449 | 1,434,000 | 0.44% | ||
| 44 | A.R.T. Advisors, LLC | 125,700 | 1,371,000 | 0.42% | ||
| 45 | SECTORAL ASSET MANAGEMENT INC | 123,135 | 1,343,000 | 0.42% | ||
| 46 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 118,921 | 1,298,000 | 0.40% | ||
| 47 | COLUMBUS CIRCLE INVESTORS | 109,264 | 1,192,000 | 0.37% | ||
| 48 | TIAA CREF INVESTMENT MANAGEMENT LLC | 93,544 | 1,021,000 | 0.32% | ||
| 49 | Invesco Ltd. | 88,321 | 964,000 | 0.30% | ||
| 50 | Fisher Asset Management, LLC | 87,842 | 958,000 | 0.30% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
