| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 4,460,377 | 196,301,000 | 18.41% | ||
| 2 | Bain Capital Public Equity Management, LLC | 2,862,025 | 125,958,000 | 11.82% | ||
| 3 | WELLINGTON MANAGEMENT GROUP LLP | 2,333,256 | 102,687,000 | 9.63% | ||
| 4 | CREDIT SUISSE AG/ | 1,562,846 | 68,781,000 | 6.45% | ||
| 5 | SECTORAL ASSET MANAGEMENT INC | 1,322,398 | 58,199,000 | 5.46% | ||
| 6 | BlackRock Fund Advisors | 897,814 | 39,513,000 | 3.71% | ||
| 7 | Granahan Investment Management, LLC | 879,602 | 38,711,000 | 3.63% | ||
| 8 | STATE STREET CORP | 821,814 | 36,168,000 | 3.39% | ||
| 9 | WESTFIELD CAPITAL MANAGEMENT CO LP | 720,980 | 31,730,000 | 2.98% | ||
| 10 | PERCEPTIVE ADVISORS LLC | 671,736 | 29,563,000 | 2.77% | ||
| 11 | TOCQUEVILLE ASSET MANAGEMENT L.P. | 571,300 | 25,143,000 | 2.36% | ||
| 12 | JANUS HENDERSON INVESTORS US LLC | 567,347 | 24,969,000 | 2.34% | ||
| 13 | VANGUARD GROUP INC | 565,998 | 24,909,000 | 2.34% | ||
| 14 | FRANKLIN RESOURCES INC | 397,800 | 17,507,000 | 1.64% | ||
| 15 | MILLENNIUM MANAGEMENT LLC | 351,734 | 15,480,000 | 1.45% | ||
| 16 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 300,000 | 13,203,000 | 1.24% | ||
| 17 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 273,600 | 12,041,000 | 1.13% | ||
| 18 | NORTHERN TRUST CORP | 263,377 | 11,591,000 | 1.09% | ||
| 19 | BlackRock Institutional Trust Company, N.A. | 244,702 | 10,769,000 | 1.01% | ||
| 20 | CITADEL ADVISORS LLC | 238,342 | 10,490,000 | 0.98% | ||
| 21 | LOOMIS SAYLES & CO L P | 232,606 | 10,237,000 | 0.96% | ||
| 22 | PUTNAM INVESTMENTS LLC | 219,300 | 9,651,000 | 0.91% | ||
| 23 | EverPoint Asset Management, LLC | 170,000 | 7,482,000 | 0.70% | ||
| 24 | Cupps Capital Management, LLC | 165,576 | 7,286,000 | 0.68% | ||
| 25 | Point72 Asset Management, L.P. | 156,500 | 6,888,000 | 0.65% | ||
| 26 | CITY NATIONAL BANK | 155,301 | 6,835,000 | 0.64% | ||
| 27 | LORD, ABBETT & CO. LLC | 152,607 | 6,716,000 | 0.63% | ||
| 28 | Bank of New York Mellon Corp | 142,177 | 6,257,000 | 0.59% | ||
| 29 | GEODE CAPITAL MANAGEMENT, LLC | 129,954 | 5,719,000 | 0.54% | ||
| 30 | Cormorant Asset Management, LP | 125,000 | 5,501,000 | 0.52% | ||
| 31 | DEUTSCHE BANK AG\ | 123,427 | 5,431,000 | 0.51% | ||
| 32 | METROPOLITAN LIFE INSURANCE CO/NY | 120,253 | 5,292,000 | 0.50% | ||
| 33 | Invesco Ltd. | 113,246 | 4,984,000 | 0.47% | ||
| 34 | TIAA CREF INVESTMENT MANAGEMENT LLC | 98,418 | 4,331,000 | 0.41% | ||
| 35 | Asset Management One Co., Ltd. | 93,279 | 4,255,000 | 0.40% | ||
| 36 | UNITED SERVICES AUTOMOBILE ASSOCIATION | 91,937 | 4,046,000 | 0.38% | ||
| 37 | Tekla Capital Management LLC | 79,150 | 3,483,000 | 0.33% | ||
| 38 | PICTET ASSET MANAGEMENT LTD | 78,400 | 3,450,000 | 0.32% | ||
| 39 | Informed Momentum Co LLC | 69,554 | 3,061,000 | 0.29% | ||
| 40 | JPMORGAN CHASE & CO | 67,864 | 2,987,000 | 0.28% | ||
| 41 | BlackRock Investment Management, LLC | 65,486 | 2,882,000 | 0.27% | ||
| 42 | SPHERA FUNDS MANAGEMENT LTD. | 63,625 | 2,800,000 | 0.26% | ||
| 43 | AXA S.A. | 61,810 | 2,720,000 | 0.26% | ||
| 44 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 58,353 | 2,569,000 | 0.24% | ||
| 45 | MASON STREET ADVISORS, LLC | 56,810 | 2,500,000 | 0.23% | ||
| 46 | RUSSELL FRANK CO/ | 53,259 | 2,344,000 | 0.22% | ||
| 47 | TEACHERS ADVISORS, LLC | 50,024 | 2,202,000 | 0.21% | ||
| 48 | ROYCE & ASSOCIATES LP | 50,000 | 2,201,000 | 0.21% | ||
| 49 | Ghost Tree Capital, LLC | 50,000 | 2,201,000 | 0.21% | ||
| 50 | ROYAL BANK OF CANADA | 46,599 | 2,051,000 | 0.19% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
