| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 4,511,167 | 117,922,000 | 19.63% | ||
| 2 | Bain Capital Public Equity Management, LLC | 2,862,025 | 74,813,000 | 12.45% | ||
| 3 | CREDIT SUISSE AG/ | 2,273,245 | 59,423,000 | 9.89% | ||
| 4 | SECTORAL ASSET MANAGEMENT INC | 1,551,274 | 40,550,000 | 6.75% | ||
| 5 | WELLINGTON MANAGEMENT GROUP LLP | 1,514,572 | 39,591,000 | 6.59% | ||
| 6 | BlackRock Fund Advisors | 903,795 | 23,625,000 | 3.93% | ||
| 7 | Granahan Investment Management, LLC | 880,463 | 23,015,000 | 3.83% | ||
| 8 | STATE STREET CORP | 845,838 | 22,113,000 | 3.68% | ||
| 9 | WESTFIELD CAPITAL MANAGEMENT CO LP | 729,250 | 19,063,000 | 3.17% | ||
| 10 | PERCEPTIVE ADVISORS LLC | 671,736 | 17,559,000 | 2.92% | ||
| 11 | JANUS HENDERSON INVESTORS US LLC | 561,656 | 14,682,000 | 2.44% | ||
| 12 | VANGUARD GROUP INC | 548,804 | 14,345,000 | 2.39% | ||
| 13 | MILLENNIUM MANAGEMENT LLC | 446,881 | 11,681,000 | 1.94% | ||
| 14 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 426,666 | 11,153,000 | 1.86% | ||
| 15 | FRANKLIN RESOURCES INC | 397,800 | 10,398,000 | 1.73% | ||
| 16 | TOCQUEVILLE ASSET MANAGEMENT L.P. | 271,813 | 7,105,000 | 1.18% | ||
| 17 | BlackRock Institutional Trust Company, N.A. | 261,195 | 6,828,000 | 1.14% | ||
| 18 | Numeric Investors LLC | 259,593 | 6,786,000 | 1.13% | ||
| 19 | PUTNAM INVESTMENTS LLC | 219,300 | 5,733,000 | 0.95% | ||
| 20 | ORBIMED ADVISORS LLC | 178,100 | 4,656,000 | 0.78% | ||
| 21 | NORTHERN TRUST CORP | 158,564 | 4,145,000 | 0.69% | ||
| 22 | SPHERA FUNDS MANAGEMENT LTD. | 150,000 | 3,921,000 | 0.65% | ||
| 23 | Cormorant Asset Management, LP | 150,000 | 3,921,000 | 0.65% | ||
| 24 | CITY NATIONAL BANK | 146,867 | 3,839,000 | 0.64% | ||
| 25 | Bank of New York Mellon Corp | 140,381 | 3,669,000 | 0.61% | ||
| 26 | Pier Capital, LLC | 135,445 | 3,541,000 | 0.59% | ||
| 27 | GEODE CAPITAL MANAGEMENT, LLC | 127,832 | 3,341,000 | 0.56% | ||
| 28 | Informed Momentum Co LLC | 109,344 | 2,858,000 | 0.48% | ||
| 29 | TIAA CREF INVESTMENT MANAGEMENT LLC | 99,686 | 2,606,000 | 0.43% | ||
| 30 | UNITED SERVICES AUTOMOBILE ASSOCIATION | 91,937 | 2,403,000 | 0.40% | ||
| 31 | RUSSELL FRANK CO/ | 83,192 | 2,174,000 | 0.36% | ||
| 32 | PICTET ASSET MANAGEMENT LTD | 82,900 | 2,167,000 | 0.36% | ||
| 33 | Invesco Ltd. | 79,583 | 2,080,000 | 0.35% | ||
| 34 | Tekla Capital Management LLC | 79,150 | 2,069,000 | 0.34% | ||
| 35 | COLUMBUS CIRCLE INVESTORS | 65,304 | 1,707,000 | 0.28% | ||
| 36 | BlackRock Investment Management, LLC | 64,901 | 1,697,000 | 0.28% | ||
| 37 | AXA S.A. | 61,810 | 1,616,000 | 0.27% | ||
| 38 | AMERIPRISE FINANCIAL INC | 61,757 | 1,614,000 | 0.27% | ||
| 39 | DEUTSCHE BANK AG\ | 57,839 | 1,510,000 | 0.25% | ||
| 40 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 50,260 | 1,314,000 | 0.22% | ||
| 41 | ROYCE & ASSOCIATES LP | 50,000 | 1,307,000 | 0.22% | ||
| 42 | BALYASNY ASSET MANAGEMENT L.P. | 41,820 | 1,093,000 | 0.18% | ||
| 43 | BLACKROCK ADVISORS LLC | 41,813 | 1,093,000 | 0.18% | ||
| 44 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 40,500 | 1,059,000 | 0.18% | ||
| 45 | Absolute Return Capital, LLC | 32,080 | 839,000 | 0.14% | ||
| 46 | TEACHERS ADVISORS, LLC | 31,278 | 818,000 | 0.14% | ||
| 47 | ALLIANCEBERNSTEIN L.P. | 31,000 | 810,000 | 0.13% | ||
| 48 | ProShare Advisors LLC | 29,063 | 760,000 | 0.13% | ||
| 49 | D. E. Shaw & Co., Inc. | 24,292 | 635,000 | 0.11% | ||
| 50 | RENAISSANCE TECHNOLOGIES LLC | 21,600 | 565,000 | 0.09% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
