| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 5,040,381 | 260,941,000 | 17.72% | ||
| 2 | WELLINGTON MANAGEMENT GROUP LLP | 2,333,209 | 120,791,000 | 8.20% | ||
| 3 | Bain Capital Public Equity Management, LLC | 2,081,932 | 107,782,000 | 7.32% | ||
| 4 | BB BIOTECH AG | 1,227,912 | 63,569,000 | 4.32% | ||
| 5 | CREDIT SUISSE AG/ | 1,183,177 | 61,252,000 | 4.16% | ||
| 6 | VANGUARD GROUP INC | 1,175,176 | 60,839,000 | 4.13% | ||
| 7 | SECTORAL ASSET MANAGEMENT INC | 1,135,130 | 58,766,000 | 3.99% | ||
| 8 | BlackRock Fund Advisors | 1,089,388 | 56,398,000 | 3.83% | ||
| 9 | Granahan Investment Management, LLC | 869,101 | 44,993,000 | 3.06% | ||
| 10 | WESTFIELD CAPITAL MANAGEMENT CO LP | 731,310 | 37,860,000 | 2.57% | ||
| 11 | STATE STREET CORP | 695,897 | 36,030,000 | 2.45% | ||
| 12 | PERCEPTIVE ADVISORS LLC | 671,736 | 34,776,000 | 2.36% | ||
| 13 | COLUMBUS CIRCLE INVESTORS | 627,372 | 32,479,000 | 2.21% | ||
| 14 | JANUS HENDERSON INVESTORS US LLC | 608,154 | 31,484,000 | 2.14% | ||
| 15 | TOCQUEVILLE ASSET MANAGEMENT L.P. | 603,308 | 31,233,000 | 2.12% | ||
| 16 | Camber Capital Management LP | 525,000 | 27,179,000 | 1.85% | ||
| 17 | BlackRock Institutional Trust Company, N.A. | 409,707 | 21,211,000 | 1.44% | ||
| 18 | FRANKLIN RESOURCES INC | 397,800 | 20,594,000 | 1.40% | ||
| 19 | WELLS FARGO & COMPANY/MN | 352,615 | 18,254,000 | 1.24% | ||
| 20 | OppenheimerFunds, Inc. | 317,350 | 16,429,000 | 1.12% | ||
| 21 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 304,600 | 15,769,000 | 1.07% | ||
| 22 | BLACKROCK ADVISORS LLC | 299,800 | 15,520,000 | 1.05% | ||
| 23 | NORTHERN TRUST CORP | 286,145 | 14,814,000 | 1.01% | ||
| 24 | LOOMIS SAYLES & CO L P | 263,918 | 13,663,000 | 0.93% | ||
| 25 | CITADEL ADVISORS LLC | 255,179 | 13,210,000 | 0.90% | ||
| 26 | EverPoint Asset Management, LLC | 229,400 | 11,876,000 | 0.81% | ||
| 27 | PUTNAM INVESTMENTS LLC | 219,300 | 11,353,000 | 0.77% | ||
| 28 | PICTET ASSET MANAGEMENT LTD | 200,186 | 10,364,000 | 0.70% | ||
| 29 | BALYASNY ASSET MANAGEMENT L.P. | 186,895 | 9,676,000 | 0.66% | ||
| 30 | CITY NATIONAL BANK | 175,779 | 9,100,000 | 0.62% | ||
| 31 | Point72 Asset Management, L.P. | 169,000 | 8,749,000 | 0.59% | ||
| 32 | Bank of New York Mellon Corp | 148,215 | 7,673,000 | 0.52% | ||
| 33 | GEODE CAPITAL MANAGEMENT, LLC | 146,088 | 7,562,000 | 0.51% | ||
| 34 | Cupps Capital Management, LLC | 135,074 | 6,992,000 | 0.47% | ||
| 35 | PFM Health Sciences, LP | 131,099 | 6,787,000 | 0.46% | ||
| 36 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 125,000 | 6,471,000 | 0.44% | ||
| 37 | LORD, ABBETT & CO. LLC | 122,595 | 6,347,000 | 0.43% | ||
| 38 | METROPOLITAN LIFE INSURANCE CO/NY | 121,650 | 6,298,000 | 0.43% | ||
| 39 | Tekla Capital Management LLC | 119,150 | 6,168,000 | 0.42% | ||
| 40 | SPHERA FUNDS MANAGEMENT LTD. | 110,000 | 5,695,000 | 0.39% | ||
| 41 | Asset Management One Co., Ltd. | 102,865 | 5,515,000 | 0.37% | ||
| 42 | Invesco Ltd. | 100,123 | 5,184,000 | 0.35% | ||
| 43 | Candriam S.C.A. | 100,000 | 5,177,000 | 0.35% | ||
| 44 | TIAA CREF INVESTMENT MANAGEMENT LLC | 95,802 | 4,960,000 | 0.34% | ||
| 45 | BlackRock Investment Management, LLC | 90,328 | 4,676,000 | 0.32% | ||
| 46 | GUGGENHEIM CAPITAL LLC | 90,117 | 4,665,000 | 0.32% | ||
| 47 | UNITED SERVICES AUTOMOBILE ASSOCIATION | 89,767 | 4,647,000 | 0.32% | ||
| 48 | Ghost Tree Capital, LLC | 85,000 | 4,400,000 | 0.30% | ||
| 49 | JPMORGAN CHASE & CO | 75,737 | 3,921,000 | 0.27% | ||
| 50 | Granite Point Capital Management, L.P. | 73,000 | 3,779,000 | 0.26% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
