| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | WELLINGTON MANAGEMENT GROUP LLP | 4,699,733 | 30,267,000 | 15.62% | ||
| 2 | SECTORAL ASSET MANAGEMENT INC | 2,615,241 | 16,842,000 | 8.69% | ||
| 3 | VANGUARD GROUP INC | 2,060,160 | 13,268,000 | 6.85% | ||
| 4 | TOCQUEVILLE ASSET MANAGEMENT L.P. | 1,487,998 | 9,583,000 | 4.94% | ||
| 5 | BlackRock Fund Advisors | 1,241,219 | 7,993,000 | 4.12% | ||
| 6 | BB BIOTECH AG | 1,182,912 | 7,618,000 | 3.93% | ||
| 7 | FMR LLC | 1,136,436 | 7,319,000 | 3.78% | ||
| 8 | FRONTIER CAPITAL MANAGEMENT CO LLC | 967,367 | 6,230,000 | 3.21% | ||
| 9 | RENAISSANCE TECHNOLOGIES LLC | 948,700 | 6,110,000 | 3.15% | ||
| 10 | Camber Capital Management LP | 893,900 | 5,757,000 | 2.97% | ||
| 11 | BlackRock Institutional Trust Company, N.A. | 810,772 | 5,221,000 | 2.69% | ||
| 12 | BLACKROCK ADVISORS LLC | 731,433 | 4,711,000 | 2.43% | ||
| 13 | STATE STREET CORP | 650,635 | 4,190,000 | 2.16% | ||
| 14 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 636,300 | 4,098,000 | 2.11% | ||
| 15 | MILLENNIUM MANAGEMENT LLC | 553,961 | 3,568,000 | 1.84% | ||
| 16 | PINNACLE ASSOCIATES LTD | 410,112 | 2,641,000 | 1.36% | ||
| 17 | NORTHERN TRUST CORP | 402,534 | 2,592,000 | 1.34% | ||
| 18 | FRANKLIN RESOURCES INC | 397,800 | 2,562,000 | 1.32% | ||
| 19 | PICTET ASSET MANAGEMENT LTD | 306,035 | 2,442,000 | 1.26% | ||
| 20 | DEUTSCHE BANK AG\ | 359,990 | 2,316,000 | 1.20% | ||
| 21 | AMERIPRISE FINANCIAL INC | 331,243 | 2,132,000 | 1.10% | ||
| 22 | BANK OF AMERICA CORP /DE/ | 316,994 | 2,041,000 | 1.05% | ||
| 23 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 299,800 | 1,931,000 | 1.00% | Call | |
| 24 | Spark Investment Management LLC | 274,100 | 1,765,000 | 0.91% | ||
| 25 | JENNISON ASSOCIATES LLC | 266,280 | 1,715,000 | 0.88% | ||
| 26 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 250,000 | 1,610,000 | 0.83% | ||
| 27 | SPHERA FUNDS MANAGEMENT LTD. | 250,000 | 1,610,000 | 0.83% | ||
| 28 | TWO SIGMA ADVISERS, LP | 225,800 | 1,454,000 | 0.75% | ||
| 29 | GEODE CAPITAL MANAGEMENT, LLC | 224,053 | 1,442,000 | 0.74% | ||
| 30 | PUTNAM INVESTMENTS LLC | 220,000 | 1,417,000 | 0.73% | ||
| 31 | A.R.T. Advisors, LLC | 219,388 | 1,412,000 | 0.73% | ||
| 32 | BlackRock Group LTD | 213,768 | 1,377,000 | 0.71% | ||
| 33 | Visium Asset Management, LP | 204,554 | 1,317,000 | 0.68% | ||
| 34 | South Dakota Investment Council | 198,800 | 1,280,000 | 0.66% | ||
| 35 | JPMORGAN CHASE & CO | 193,539 | 1,247,000 | 0.64% | ||
| 36 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 176,400 | 1,136,000 | 0.59% | Put | |
| 37 | GUGGENHEIM CAPITAL LLC | 166,541 | 1,073,000 | 0.55% | ||
| 38 | BlackRock Investment Management, LLC | 156,956 | 1,011,000 | 0.52% | ||
| 39 | CITADEL ADVISORS LLC | 150,594 | 970,000 | 0.50% | ||
| 40 | Bank of New York Mellon Corp | 145,024 | 934,000 | 0.48% | ||
| 41 | MACKENZIE FINANCIAL CORP | 138,200 | 890,000 | 0.46% | ||
| 42 | WADDELL & REED FINANCIAL INC | 131,684 | 848,000 | 0.44% | ||
| 43 | Fisher Asset Management, LLC | 85,700 | 764,000 | 0.39% | ||
| 44 | NORGES BANK | 110,291 | 710,000 | 0.37% | ||
| 45 | TIAA CREF INVESTMENT MANAGEMENT LLC | 109,257 | 704,000 | 0.36% | ||
| 46 | PRUDENTIAL FINANCIAL INC | 108,850 | 701,000 | 0.36% | ||
| 47 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 100,786 | 650,000 | 0.34% | ||
| 48 | Brandywine Global Investment Management, LLC | 91,791 | 592,000 | 0.31% | ||
| 49 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 85,800 | 553,000 | 0.29% | ||
| 50 | AQR CAPITAL MANAGEMENT LLC | 85,397 | 550,000 | 0.28% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
