| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | WASATCH ADVISORS LP | 7,060,135 | 36,713,000 | 16.62% | ||
| 2 | BlackRock Finance, Inc. | 5,618,851 | 29,217,000 | 13.22% | ||
| 3 | BAKER BROS. ADVISORS LP | 4,530,901 | 23,561,000 | 10.66% | ||
| 4 | VANGUARD GROUP INC | 3,087,650 | 16,056,000 | 7.27% | ||
| 5 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 3,000,000 | 15,600,000 | 7.06% | ||
| 6 | FMR LLC | 1,611,083 | 8,378,000 | 3.79% | ||
| 7 | STATE STREET CORP | 1,231,989 | 6,409,000 | 2.90% | ||
| 8 | Granahan Investment Management, LLC | 1,032,859 | 5,371,000 | 2.43% | ||
| 9 | FIC CAPITAL INC | 940,909 | 4,893,000 | 2.21% | ||
| 10 | NORTHERN TRUST CORP | 903,176 | 4,697,000 | 2.13% | ||
| 11 | CASDIN CAPITAL, LLC | 850,000 | 4,420,000 | 2.00% | ||
| 12 | DEERFIELD MANAGEMENT COMPANY, L.P. | 837,963 | 4,357,000 | 1.97% | ||
| 13 | ROYCE & ASSOCIATES LP | 751,100 | 3,906,000 | 1.77% | ||
| 14 | GEODE CAPITAL MANAGEMENT, LLC | 633,964 | 3,296,000 | 1.49% | ||
| 15 | ALTRINSIC GLOBAL ADVISORS LLC | 630,000 | 3,276,000 | 1.48% | ||
| 16 | Cormorant Asset Management, LP | 600,000 | 3,120,000 | 1.41% | ||
| 17 | Opaleye Management Inc. | 581,000 | 3,021,000 | 1.37% | ||
| 18 | FRONTIER CAPITAL MANAGEMENT CO LLC | 499,803 | 2,599,000 | 1.18% | ||
| 19 | TOCQUEVILLE ASSET MANAGEMENT L.P. | 390,915 | 2,033,000 | 0.92% | ||
| 20 | DEUTSCHE BANK AG\ | 389,981 | 2,027,000 | 0.92% | ||
| 21 | CREDIT SUISSE AG/ | 363,278 | 1,889,000 | 0.85% | ||
| 22 | COLUMBUS CIRCLE INVESTORS | 355,167 | 1,847,000 | 0.84% | ||
| 23 | Bank of New York Mellon Corp | 333,305 | 1,732,000 | 0.78% | ||
| 24 | MORGAN STANLEY | 308,705 | 1,605,000 | 0.73% | ||
| 25 | WELLS FARGO & COMPANY/MN | 295,770 | 1,538,000 | 0.70% | ||
| 26 | TIAA CREF INVESTMENT MANAGEMENT LLC | 280,112 | 1,457,000 | 0.66% | ||
| 27 | Candriam S.C.A. | 270,000 | 1,404,000 | 0.64% | ||
| 28 | UNITED SERVICES AUTOMOBILE ASSOCIATION | 268,100 | 1,394,000 | 0.63% | ||
| 29 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 265,735 | 1,382,000 | 0.63% | ||
| 30 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 220,400 | 1,146,000 | 0.52% | Put | |
| 31 | MILLENNIUM MANAGEMENT LLC | 219,491 | 1,141,000 | 0.52% | ||
| 32 | D. E. Shaw & Co., Inc. | 206,704 | 1,075,000 | 0.49% | ||
| 33 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 183,000 | 952,000 | 0.43% | Call | |
| 34 | TEACHERS ADVISORS, LLC | 180,858 | 940,000 | 0.43% | ||
| 35 | Iguana Healthcare Management, LLC | 150,000 | 780,000 | 0.35% | ||
| 36 | QS Investors, LLC | 145,236 | 755,000 | 0.34% | ||
| 37 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 136,781 | 711,000 | 0.32% | ||
| 38 | KEYBANK NATIONAL ASSOCIATION/OH | 135,247 | 703,000 | 0.32% | ||
| 39 | PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 134,622 | 700,000 | 0.32% | ||
| 40 | DIMENSIONAL FUND ADVISORS LP | 128,764 | 670,000 | 0.30% | ||
| 41 | PRICE T ROWE ASSOCIATES INC /MD/ | 128,200 | 667,000 | 0.30% | ||
| 42 | GROUP ONE TRADING LLC | 115,815 | 602,000 | 0.27% | ||
| 43 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 114,300 | 594,000 | 0.27% | ||
| 44 | Swiss National Bank | 113,560 | 591,000 | 0.27% | ||
| 45 | PARAMETRIC PORTFOLIO ASSOCIATES LLC | 111,136 | 578,000 | 0.26% | ||
| 46 | PDT Partners, LLC | 107,000 | 556,000 | 0.25% | ||
| 47 | HIGHBRIDGE CAPITAL MANAGEMENT LLC | 95,287 | 496,000 | 0.22% | ||
| 48 | ALLIANCEBERNSTEIN L.P. | 90,241 | 469,000 | 0.21% | ||
| 49 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 86,289 | 449,000 | 0.20% | ||
| 50 | RHUMBLINE ADVISERS | 85,082 | 442,000 | 0.20% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
