| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | PERCEPTIVE ADVISORS LLC | 3,833,128 | 74,823,000 | 9.16% | ||
| 2 | Point72 Asset Management, L.P. | 2,962,231 | 57,823,000 | 7.08% | ||
| 3 | VANGUARD GROUP INC | 2,944,026 | 57,468,000 | 7.03% | ||
| 4 | STATE STREET CORP | 2,467,376 | 48,168,000 | 5.90% | ||
| 5 | FMR LLC | 1,802,897 | 35,193,000 | 4.31% | ||
| 6 | BlackRock Fund Advisors | 1,661,818 | 32,439,000 | 3.97% | ||
| 7 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 1,577,900 | 30,801,000 | 3.77% | Call | |
| 8 | CITADEL ADVISORS LLC | 1,522,052 | 29,710,000 | 3.64% | ||
| 9 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 1,310,800 | 25,587,000 | 3.13% | Put | |
| 10 | Jefferies Group LLC | 1,157,779 | 22,600,000 | 2.77% | ||
| 11 | Avoro Capital Advisors LLC | 1,155,000 | 22,546,000 | 2.76% | ||
| 12 | Jefferies Group LLC | 1,153,700 | 22,520,000 | 2.76% | Put | |
| 13 | COLUMBIA WANGER ASSET MANAGEMENT LLC | 1,119,893 | 21,860,000 | 2.68% | ||
| 14 | LORD, ABBETT & CO. LLC | 1,084,067 | 21,161,000 | 2.59% | ||
| 15 | BlackRock Institutional Trust Company, N.A. | 1,068,913 | 20,865,000 | 2.55% | ||
| 16 | PointState Capital LP | 900,000 | 17,568,000 | 2.15% | ||
| 17 | Tourbillon Capital Partners, L.P. | 805,243 | 15,718,000 | 1.92% | ||
| 18 | D. E. Shaw & Co., Inc. | 751,942 | 14,678,000 | 1.80% | ||
| 19 | FRANKLIN RESOURCES INC | 691,900 | 13,506,000 | 1.65% | ||
| 20 | DEUTSCHE BANK AG\ | 660,365 | 12,888,000 | 1.58% | ||
| 21 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 577,047 | 11,264,000 | 1.38% | ||
| 22 | PERCEPTIVE ADVISORS LLC | 550,000 | 10,736,000 | 1.31% | Call | |
| 23 | NORTHERN TRUST CORP | 531,397 | 10,373,000 | 1.27% | ||
| 24 | SABBY MANAGEMENT, LLC | 505,937 | 9,876,000 | 1.21% | ||
| 25 | CREDIT SUISSE AG/ | 452,810 | 8,839,000 | 1.08% | ||
| 26 | QVT Financial LP | 449,526 | 8,775,000 | 1.07% | ||
| 27 | MORGAN STANLEY | 445,678 | 8,698,000 | 1.06% | ||
| 28 | Invesco Ltd. | 391,168 | 7,635,000 | 0.93% | ||
| 29 | A.R.T. Advisors, LLC | 382,227 | 7,461,000 | 0.91% | ||
| 30 | EVENTIDE ASSET MANAGEMENT, LLC | 332,300 | 6,486,000 | 0.79% | ||
| 31 | GEODE CAPITAL MANAGEMENT, LLC | 282,292 | 5,510,000 | 0.67% | ||
| 32 | TANG CAPITAL MANAGEMENT LLC | 250,000 | 4,880,000 | 0.60% | ||
| 33 | Bank of New York Mellon Corp | 219,536 | 4,285,000 | 0.52% | ||
| 34 | TIAA CREF INVESTMENT MANAGEMENT LLC | 216,707 | 4,230,000 | 0.52% | ||
| 35 | GOLDMAN SACHS GROUP INC | 210,000 | 4,099,000 | 0.50% | Put | |
| 36 | Artal Group S.A. | 200,000 | 3,904,000 | 0.48% | Call | |
| 37 | Nantahala Capital Management, LLC | 200,000 | 3,904,000 | 0.48% | Call | |
| 38 | Jefferies Group LLC | 191,000 | 3,728,000 | 0.46% | Call | |
| 39 | OXFORD ASSET MANAGEMENT LLP | 187,149 | 3,653,000 | 0.45% | ||
| 40 | MASON CAPITAL MANAGEMENT LLC | 175,000 | 3,416,000 | 0.42% | ||
| 41 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 166,900 | 3,258,000 | 0.40% | ||
| 42 | BlackRock Investment Management, LLC | 155,963 | 3,044,000 | 0.37% | ||
| 43 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 151,050 | 2,949,000 | 0.36% | ||
| 44 | GREAT POINT PARTNERS LLC | 150,000 | 2,928,000 | 0.36% | Call | |
| 45 | Rock Springs Capital Management LP | 131,000 | 2,557,000 | 0.31% | ||
| 46 | TEACHERS ADVISORS, LLC | 115,905 | 2,262,000 | 0.28% | ||
| 47 | Tourbillon Capital Partners, L.P. | 115,000 | 2,245,000 | 0.27% | Call | |
| 48 | GOLDMAN SACHS GROUP INC | 114,927 | 2,243,000 | 0.27% | ||
| 49 | JANE STREET GROUP, LLC | 109,600 | 2,139,000 | 0.26% | Put | |
| 50 | Avoro Capital Advisors LLC | 307,500 | 2,006,000 | 0.25% | Call |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
