| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BlackRock Finance, Inc. | 5,292,729 | 156,664,000 | 11.79% | ||
| 2 | VANGUARD GROUP INC | 4,096,486 | 121,256,000 | 9.12% | ||
| 3 | STATE STREET CORP | 3,197,127 | 94,641,000 | 7.12% | ||
| 4 | Carlson Capital, L.P. | 1,845,702 | 54,633,000 | 4.11% | ||
| 5 | PERCEPTIVE ADVISORS LLC | 1,771,029 | 52,422,000 | 3.94% | ||
| 6 | HealthCor Management, L.P. | 1,550,000 | 45,880,000 | 3.45% | ||
| 7 | Tourbillon Capital Partners, L.P. | 1,537,518 | 45,511,000 | 3.42% | ||
| 8 | Camber Capital Management LP | 1,350,000 | 39,960,000 | 3.01% | ||
| 9 | FMR LLC | 1,121,997 | 33,211,000 | 2.50% | ||
| 10 | ORBIMED ADVISORS LLC | 1,054,300 | 31,207,000 | 2.35% | ||
| 11 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 1,043,100 | 30,876,000 | 2.32% | Put | |
| 12 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 825,200 | 24,426,000 | 1.84% | Call | |
| 13 | EMERALD ADVISERS, LLC | 818,705 | 24,234,000 | 1.82% | ||
| 14 | Point72 Asset Management, L.P. | 803,300 | 23,778,000 | 1.79% | ||
| 15 | PointState Capital LP | 638,900 | 18,911,000 | 1.42% | ||
| 16 | NORTHERN TRUST CORP | 608,824 | 18,021,000 | 1.36% | ||
| 17 | CITADEL ADVISORS LLC | 608,728 | 18,018,000 | 1.36% | ||
| 18 | EMERALD MUTUAL FUND ADVISERS TRUST | 604,467 | 17,892,000 | 1.35% | ||
| 19 | EAGLE ASSET MANAGEMENT INC | 598,309 | 17,709,000 | 1.33% | ||
| 20 | NORGES BANK | 573,205 | 16,967,000 | 1.28% | ||
| 21 | JENNISON ASSOCIATES LLC | 563,333 | 16,675,000 | 1.25% | ||
| 22 | Elk Creek Partners, LLC | 562,522 | 16,651,000 | 1.25% | ||
| 23 | GOLDMAN SACHS GROUP INC | 532,892 | 15,773,000 | 1.19% | ||
| 24 | Tekla Capital Management LLC | 511,600 | 15,143,000 | 1.14% | ||
| 25 | SPHERA FUNDS MANAGEMENT LTD. | 483,047 | 14,298,000 | 1.08% | ||
| 26 | BALYASNY ASSET MANAGEMENT L.P. | 439,245 | 13,002,000 | 0.98% | ||
| 27 | GEODE CAPITAL MANAGEMENT, LLC | 421,047 | 12,462,000 | 0.94% | ||
| 28 | PINNACLE ASSOCIATES LTD | 361,701 | 10,706,000 | 0.81% | ||
| 29 | Invesco Ltd. | 361,041 | 10,687,000 | 0.80% | ||
| 30 | PRICE T ROWE ASSOCIATES INC /MD/ | 360,673 | 10,676,000 | 0.80% | ||
| 31 | Tourbillon Capital Partners, L.P. | 353,700 | 10,470,000 | 0.79% | Call | |
| 32 | CADIAN CAPITAL MANAGEMENT, LP | 345,811 | 10,236,000 | 0.77% | ||
| 33 | PDT Partners, LLC | 338,997 | 10,034,000 | 0.75% | ||
| 34 | Artal Group S.A. | 300,000 | 8,880,000 | 0.67% | Call | |
| 35 | TEACHERS ADVISORS, LLC | 290,993 | 8,613,000 | 0.65% | ||
| 36 | Hudson Bay Capital Management LP | 277,927 | 8,227,000 | 0.62% | ||
| 37 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 267,679 | 7,923,000 | 0.60% | ||
| 38 | DEUTSCHE BANK AG\ | 263,160 | 7,787,000 | 0.59% | ||
| 39 | Bank of New York Mellon Corp | 247,924 | 7,339,000 | 0.55% | ||
| 40 | SAMLYN CAPITAL, LLC | 234,300 | 6,935,000 | 0.52% | ||
| 41 | CAPITAL FUND MANAGEMENT S.A. | 223,101 | 6,604,000 | 0.50% | ||
| 42 | QVT Financial LP | 221,691 | 6,562,000 | 0.49% | ||
| 43 | WOLVERINE TRADING LP /BD | 218,100 | 6,327,000 | 0.48% | Call | |
| 44 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 205,187 | 6,074,000 | 0.46% | ||
| 45 | TIAA CREF INVESTMENT MANAGEMENT LLC | 200,002 | 5,920,000 | 0.45% | ||
| 46 | Artal Group S.A. | 200,000 | 5,920,000 | 0.45% | ||
| 47 | Rock Springs Capital Management LP | 194,000 | 5,742,000 | 0.43% | ||
| 48 | WOLVERINE TRADING LP /BD | 196,800 | 5,709,000 | 0.43% | Put | |
| 49 | MORGAN STANLEY | 190,110 | 5,628,000 | 0.42% | ||
| 50 | CREDIT SUISSE AG/ | 186,295 | 5,515,000 | 0.41% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
