| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 1,571,477 | 121,789,000 | 13.40% | ||
| 2 | BAKER BROS. ADVISORS LP | 1,327,451 | 102,878,000 | 11.32% | ||
| 3 | PRICE T ROWE ASSOCIATES INC /MD/ | 1,204,526 | 90,416,000 | 9.95% | ||
| 4 | DEERFIELD MANAGEMENT COMPANY, L.P. | 631,192 | 48,917,000 | 5.38% | ||
| 5 | LORD, ABBETT & CO. LLC | 534,921 | 41,457,000 | 4.56% | ||
| 6 | WELLINGTON MANAGEMENT GROUP LLP | 512,220 | 38,403,000 | 4.23% | ||
| 7 | GILDER GAGNON HOWE & CO LLC | 456,604 | 35,387,000 | 3.89% | ||
| 8 | BLACKROCK ADVISORS LLC | 442,244 | 34,274,000 | 3.77% | ||
| 9 | Bain Capital Public Equity Management, LLC | 428,096 | 33,177,000 | 3.65% | ||
| 10 | VANGUARD GROUP INC | 424,387 | 32,890,000 | 3.62% | ||
| 11 | Capital World Investors | 358,020 | 27,747,000 | 3.05% | ||
| 12 | WELLS FARGO & COMPANY/MN | 305,818 | 23,701,000 | 2.61% | ||
| 13 | BlackRock Group LTD | 256,143 | 19,851,000 | 2.18% | ||
| 14 | Clearbridge Investments, LLC | 248,210 | 19,236,000 | 2.12% | ||
| 15 | RS INVESTMENT MANAGEMENT CO LLC | 231,162 | 17,915,000 | 1.97% | ||
| 16 | JANUS HENDERSON INVESTORS US LLC | 229,628 | 17,796,000 | 1.96% | ||
| 17 | MORGAN STANLEY | 211,471 | 16,389,000 | 1.80% | ||
| 18 | WADDELL & REED FINANCIAL INC | 207,685 | 16,096,000 | 1.77% | ||
| 19 | BlackRock Fund Advisors | 203,291 | 15,755,000 | 1.73% | ||
| 20 | Allianz Asset Management GmbH | 185,580 | 14,383,000 | 1.58% | ||
| 21 | FRANKLIN RESOURCES INC | 173,300 | 13,431,000 | 1.48% | ||
| 22 | BlackRock Institutional Trust Company, N.A. | 171,132 | 13,263,000 | 1.46% | ||
| 23 | ORBIMED ADVISORS LLC | 127,000 | 9,843,000 | 1.08% | ||
| 24 | FEDERATED HERMES, INC. | 107,500 | 8,332,000 | 0.92% | ||
| 25 | STATE STREET CORP | 69,699 | 5,405,000 | 0.59% | ||
| 26 | Artal Group S.A. | 60,000 | 4,650,000 | 0.51% | ||
| 27 | EverPoint Asset Management, LLC | 60,000 | 4,650,000 | 0.51% | ||
| 28 | Candriam S.C.A. | 55,000 | 4,263,000 | 0.47% | ||
| 29 | DSAM Partners (London) Ltd | 54,484 | 4,223,000 | 0.46% | ||
| 30 | TEACHERS ADVISORS, LLC | 52,754 | 4,088,000 | 0.45% | ||
| 31 | FIL Ltd | 51,235 | 3,971,000 | 0.44% | ||
| 32 | AMERIPRISE FINANCIAL INC | 45,088 | 3,494,000 | 0.38% | ||
| 33 | JPMORGAN CHASE & CO | 42,998 | 3,333,000 | 0.37% | ||
| 34 | Alyeska Investment Group, L.P. | 42,618 | 3,303,000 | 0.36% | ||
| 35 | C WorldWide Group Holding A/S | 37,000 | 2,868,000 | 0.32% | ||
| 36 | Asset Management One Co., Ltd. | 35,610 | 2,639,000 | 0.29% | ||
| 37 | Rock Springs Capital Management LP | 33,106 | 2,566,000 | 0.28% | ||
| 38 | BlackRock Finance, Inc. | 32,977 | 2,556,000 | 0.28% | ||
| 39 | BlackRock Investment Management, LLC | 32,715 | 2,535,000 | 0.28% | ||
| 40 | Bank of New York Mellon Corp | 32,031 | 2,482,000 | 0.27% | ||
| 41 | AXA S.A. | 31,954 | 2,476,000 | 0.27% | ||
| 42 | MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 28,014 | 2,171,086 | 0.24% | ||
| 43 | BAILARD, INC. | 28,000 | 2,170,000 | 0.24% | ||
| 44 | ArrowMark Colorado Holdings LLC | 25,337 | 1,964,000 | 0.22% | ||
| 45 | PANAGORA ASSET MANAGEMENT INC | 25,306 | 1,961,000 | 0.22% | ||
| 46 | NORTHERN TRUST CORP | 20,287 | 1,572,000 | 0.17% | ||
| 47 | EMERALD ADVISERS, LLC | 25,099 | 1,397,000 | 0.15% | ||
| 48 | PRINCIPAL FINANCIAL GROUP INC | 18,000 | 1,394,000 | 0.15% | ||
| 49 | Informed Momentum Co LLC | 17,954 | 1,391,000 | 0.15% | ||
| 50 | MARINER INVESTMENT GROUP LLC | 16,750 | 1,298,000 | 0.14% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
