| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 4,615,957 | 230,336,000 | 16.63% | ||
| 2 | PRICE T ROWE ASSOCIATES INC /MD/ | 3,041,716 | 151,782,000 | 10.96% | ||
| 3 | VANGUARD GROUP INC | 1,736,974 | 86,674,000 | 6.26% | ||
| 4 | JPMORGAN CHASE & CO | 1,436,497 | 71,681,000 | 5.18% | ||
| 5 | FEDERATED HERMES, INC. | 1,371,200 | 68,423,000 | 4.94% | ||
| 6 | BAKER BROS. ADVISORS LP | 1,318,341 | 65,785,000 | 4.75% | ||
| 7 | MILLENNIUM MANAGEMENT LLC | 1,016,626 | 50,730,000 | 3.66% | ||
| 8 | BlackRock Fund Advisors | 1,007,040 | 50,251,000 | 3.63% | ||
| 9 | SOFINNOVA MANAGEMENT VIII, L.L.C. | 904,986 | 45,159,000 | 3.26% | ||
| 10 | STATE STREET CORP | 902,606 | 45,044,000 | 3.25% | ||
| 11 | Clearbridge Investments, LLC | 671,447 | 33,505,000 | 2.42% | ||
| 12 | Rock Springs Capital Management LP | 625,000 | 31,188,000 | 2.25% | ||
| 13 | LORD, ABBETT & CO. LLC | 564,746 | 28,181,000 | 2.03% | ||
| 14 | BlackRock Institutional Trust Company, N.A. | 545,612 | 27,226,000 | 1.97% | ||
| 15 | GOLDMAN SACHS GROUP INC | 498,107 | 24,855,000 | 1.79% | ||
| 16 | AMERICAN CENTURY COMPANIES INC | 485,074 | 24,205,000 | 1.75% | ||
| 17 | Capital World Investors | 428,020 | 21,358,000 | 1.54% | ||
| 18 | CITADEL ADVISORS LLC | 406,912 | 20,305,000 | 1.47% | ||
| 19 | JANUS HENDERSON INVESTORS US LLC | 377,993 | 18,865,000 | 1.36% | ||
| 20 | VICTORY CAPITAL MANAGEMENT INC | 370,272 | 18,476,000 | 1.33% | ||
| 21 | WELLINGTON MANAGEMENT GROUP LLP | 368,495 | 18,388,000 | 1.33% | ||
| 22 | Bain Capital Public Equity Management, LLC | 328,113 | 16,373,000 | 1.18% | ||
| 23 | DEERFIELD MANAGEMENT COMPANY, L.P. | 283,000 | 14,122,000 | 1.02% | ||
| 24 | Invesco Ltd. | 275,867 | 13,765,000 | 0.99% | ||
| 25 | AMERIPRISE FINANCIAL INC | 238,740 | 11,914,000 | 0.86% | ||
| 26 | NORTHERN TRUST CORP | 229,209 | 11,438,000 | 0.83% | ||
| 27 | WELLS FARGO & COMPANY/MN | 225,617 | 11,258,000 | 0.81% | ||
| 28 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 185,036 | 9,233,000 | 0.67% | ||
| 29 | GEODE CAPITAL MANAGEMENT, LLC | 168,870 | 8,426,000 | 0.61% | ||
| 30 | NORGES BANK | 164,960 | 8,232,000 | 0.59% | ||
| 31 | AXA S.A. | 156,272 | 7,798,000 | 0.56% | ||
| 32 | EVENTIDE ASSET MANAGEMENT, LLC | 150,000 | 7,485,000 | 0.54% | ||
| 33 | PICTET ASSET MANAGEMENT LTD | 145,199 | 7,245,000 | 0.52% | ||
| 34 | CASDIN CAPITAL, LLC | 128,500 | 6,412,000 | 0.46% | ||
| 35 | BLACKROCK ADVISORS LLC | 127,069 | 6,340,000 | 0.46% | ||
| 36 | MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 114,074 | 5,692,000 | 0.41% | ||
| 37 | HIGHLAND CAPITAL MANAGEMENT LP | 112,000 | 5,589,000 | 0.40% | ||
| 38 | Bank of New York Mellon Corp | 100,127 | 4,996,000 | 0.36% | ||
| 39 | CITIGROUP INC | 99,737 | 4,976,000 | 0.36% | ||
| 40 | MARSHALL WACE, LLP | 94,927 | 4,737,000 | 0.34% | ||
| 41 | MORGAN STANLEY | 83,660 | 4,175,000 | 0.30% | ||
| 42 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 80,146 | 4,000,000 | 0.29% | ||
| 43 | Ghost Tree Capital, LLC | 80,000 | 3,992,000 | 0.29% | ||
| 44 | BlackRock Investment Management, LLC | 76,945 | 3,840,000 | 0.28% | ||
| 45 | TD ASSET MANAGEMENT INC | 73,151 | 3,650,000 | 0.26% | ||
| 46 | BALYASNY ASSET MANAGEMENT L.P. | 71,600 | 3,573,000 | 0.26% | ||
| 47 | BlackRock Group LTD | 68,841 | 3,434,000 | 0.25% | ||
| 48 | C WorldWide Group Holding A/S | 55,666 | 2,778,000 | 0.20% | ||
| 49 | TIAA CREF INVESTMENT MANAGEMENT LLC | 55,276 | 2,758,000 | 0.20% | ||
| 50 | TOCQUEVILLE ASSET MANAGEMENT L.P. | 54,350 | 2,712,000 | 0.20% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
