| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 4,066,458 | 120,001,000 | 20.65% | ||
| 2 | PRICE T ROWE ASSOCIATES INC /MD/ | 2,512,607 | 74,147,000 | 12.76% | ||
| 3 | BAKER BROS. ADVISORS LP | 1,262,382 | 37,253,000 | 6.41% | ||
| 4 | VANGUARD GROUP INC | 1,173,880 | 34,641,000 | 5.96% | ||
| 5 | FEDERATED HERMES, INC. | 1,143,994 | 33,759,000 | 5.81% | ||
| 6 | JPMORGAN CHASE & CO | 679,220 | 20,045,000 | 3.45% | ||
| 7 | Clearbridge Investments, LLC | 641,661 | 18,935,000 | 3.26% | ||
| 8 | Rock Springs Capital Management LP | 580,500 | 17,131,000 | 2.95% | ||
| 9 | BlackRock Fund Advisors | 565,465 | 16,687,000 | 2.87% | ||
| 10 | RS INVESTMENT MANAGEMENT CO LLC | 540,387 | 15,947,000 | 2.74% | ||
| 11 | WELLINGTON MANAGEMENT GROUP LLP | 436,232 | 12,872,000 | 2.22% | ||
| 12 | STATE STREET CORP | 431,712 | 12,742,000 | 2.19% | ||
| 13 | Bain Capital Public Equity Management, LLC | 424,114 | 12,516,000 | 2.15% | ||
| 14 | LORD, ABBETT & CO. LLC | 411,830 | 12,153,000 | 2.09% | ||
| 15 | Capital World Investors | 403,020 | 11,893,000 | 2.05% | ||
| 16 | AMERICAN CENTURY COMPANIES INC | 374,000 | 11,037,000 | 1.90% | ||
| 17 | Invesco Ltd. | 349,700 | 10,320,000 | 1.78% | ||
| 18 | BlackRock Institutional Trust Company, N.A. | 328,434 | 9,692,000 | 1.67% | ||
| 19 | AXA S.A. | 247,788 | 7,312,000 | 1.26% | ||
| 20 | AMERIPRISE FINANCIAL INC | 234,560 | 6,922,000 | 1.19% | ||
| 21 | WADDELL & REED FINANCIAL INC | 207,685 | 6,129,000 | 1.05% | ||
| 22 | CASDIN CAPITAL, LLC | 170,000 | 5,017,000 | 0.86% | ||
| 23 | UBS Group AG | 155,000 | 4,574,000 | 0.79% | Put | |
| 24 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 152,972 | 4,514,000 | 0.78% | ||
| 25 | EVENTIDE ASSET MANAGEMENT, LLC | 150,000 | 4,427,000 | 0.76% | ||
| 26 | MORGAN STANLEY | 134,398 | 3,967,000 | 0.68% | ||
| 27 | EMERALD ADVISERS, LLC | 123,970 | 3,658,000 | 0.63% | ||
| 28 | NORTHERN TRUST CORP | 109,561 | 3,233,000 | 0.56% | ||
| 29 | GEODE CAPITAL MANAGEMENT, LLC | 100,565 | 2,967,000 | 0.51% | ||
| 30 | EMERALD MUTUAL FUND ADVISERS TRUST | 92,360 | 2,726,000 | 0.47% | ||
| 31 | C WorldWide Group Holding A/S | 80,400 | 2,373,000 | 0.41% | ||
| 32 | NORGES BANK | 73,859 | 2,180,000 | 0.38% | ||
| 33 | Bank of New York Mellon Corp | 65,902 | 1,945,000 | 0.33% | ||
| 34 | TD ASSET MANAGEMENT INC | 65,787 | 1,941,000 | 0.33% | ||
| 35 | OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 64,310 | 1,898,000 | 0.33% | ||
| 36 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 63,471 | 1,873,000 | 0.32% | ||
| 37 | GOLDMAN SACHS GROUP INC | 57,265 | 1,690,000 | 0.29% | ||
| 38 | GOLDMAN SACHS GROUP INC | 55,700 | 1,644,000 | 0.28% | Put | |
| 39 | TOCQUEVILLE ASSET MANAGEMENT L.P. | 48,650 | 1,436,000 | 0.25% | ||
| 40 | GOLDMAN SACHS GROUP INC | 47,600 | 1,405,000 | 0.24% | Call | |
| 41 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 41,368 | 1,221,000 | 0.21% | ||
| 42 | BAILARD, INC. | 40,600 | 1,198,000 | 0.21% | ||
| 43 | MILLENNIUM MANAGEMENT LLC | 39,900 | 1,177,000 | 0.20% | ||
| 44 | ALLIANCEBERNSTEIN L.P. | 36,700 | 1,083,000 | 0.19% | ||
| 45 | MARINER INVESTMENT GROUP LLC | 34,350 | 1,014,000 | 0.17% | ||
| 46 | BlackRock Investment Management, LLC | 31,687 | 935,000 | 0.16% | ||
| 47 | Opus Point Partners Management, LLC | 31,500 | 930,000 | 0.16% | ||
| 48 | ALPS ADVISORS INC | 30,448 | 899,000 | 0.15% | ||
| 49 | Candriam S.C.A. | 30,000 | 881,000 | 0.15% | ||
| 50 | Swiss National Bank | 29,700 | 846,000 | 0.15% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
