| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 3,684,006 | 153,734,000 | 23.06% | ||
| 2 | BAKER BROS. ADVISORS LP | 1,262,382 | 52,679,000 | 7.90% | ||
| 3 | PRICE T ROWE ASSOCIATES INC /MD/ | 1,257,408 | 52,472,000 | 7.87% | ||
| 4 | VANGUARD GROUP INC | 775,571 | 32,365,000 | 4.86% | ||
| 5 | STATE STREET CORP | 672,455 | 28,063,000 | 4.21% | ||
| 6 | FEDERATED HERMES, INC. | 661,400 | 27,601,000 | 4.14% | ||
| 7 | LORD, ABBETT & CO. LLC | 628,771 | 26,239,000 | 3.94% | ||
| 8 | Rock Springs Capital Management LP | 500,000 | 20,865,000 | 3.13% | ||
| 9 | RS INVESTMENT MANAGEMENT CO LLC | 442,392 | 18,461,000 | 2.77% | ||
| 10 | Bain Capital Public Equity Management, LLC | 428,096 | 17,864,000 | 2.68% | ||
| 11 | Capital World Investors | 403,020 | 16,818,000 | 2.52% | ||
| 12 | ALPS ADVISORS INC | 38,415 | 16,031,000 | 2.40% | ||
| 13 | BARCLAYS PLC | 383,800 | 15,736,000 | 2.36% | Put | |
| 14 | Invesco Ltd. | 348,319 | 14,536,000 | 2.18% | ||
| 15 | WELLINGTON MANAGEMENT GROUP LLP | 285,280 | 11,905,000 | 1.79% | ||
| 16 | AMERICAN CENTURY COMPANIES INC | 268,386 | 11,200,000 | 1.68% | ||
| 17 | HIGHLAND CAPITAL MANAGEMENT LP | 266,059 | 11,103,000 | 1.67% | ||
| 18 | BlackRock Institutional Trust Company, N.A. | 259,927 | 10,847,000 | 1.63% | ||
| 19 | Clearbridge Investments, LLC | 248,006 | 10,349,000 | 1.55% | ||
| 20 | WADDELL & REED FINANCIAL INC | 207,685 | 8,666,000 | 1.30% | ||
| 21 | BlackRock Fund Advisors | 191,832 | 8,005,000 | 1.20% | ||
| 22 | AXA S.A. | 165,722 | 6,916,000 | 1.04% | ||
| 23 | MORGAN STANLEY | 156,391 | 6,526,000 | 0.98% | ||
| 24 | BLACKROCK ADVISORS LLC | 155,363 | 6,483,000 | 0.97% | ||
| 25 | Jefferies Group LLC | 145,600 | 6,076,000 | 0.91% | Call | |
| 26 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 140,300 | 5,855,000 | 0.88% | ||
| 27 | WELLS FARGO & COMPANY/MN | 121,709 | 5,079,000 | 0.76% | ||
| 28 | BlackRock Group LTD | 93,132 | 3,887,000 | 0.58% | ||
| 29 | NORTHERN TRUST CORP | 91,976 | 3,838,000 | 0.58% | ||
| 30 | AMERIPRISE FINANCIAL INC | 82,277 | 3,436,000 | 0.52% | ||
| 31 | GEODE CAPITAL MANAGEMENT, LLC | 78,408 | 3,271,000 | 0.49% | ||
| 32 | C WorldWide Group Holding A/S | 77,220 | 3,222,000 | 0.48% | ||
| 33 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 75,426 | 3,148,000 | 0.47% | ||
| 34 | SPHERA FUNDS MANAGEMENT LTD. | 70,000 | 2,921,000 | 0.44% | ||
| 35 | MARINER INVESTMENT GROUP LLC | 59,350 | 2,477,000 | 0.37% | ||
| 36 | Jefferies Group LLC | 57,100 | 2,383,000 | 0.36% | Put | |
| 37 | JPMORGAN CHASE & CO | 50,716 | 2,117,000 | 0.32% | ||
| 38 | EVENTIDE ASSET MANAGEMENT, LLC | 49,000 | 2,045,000 | 0.31% | ||
| 39 | Rock Springs Capital Management LP | 45,700 | 1,907,000 | 0.29% | Put | |
| 40 | Bank of New York Mellon Corp | 40,875 | 1,705,000 | 0.26% | ||
| 41 | ALLIANCEBERNSTEIN L.P. | 39,140 | 1,633,000 | 0.24% | ||
| 42 | TOCQUEVILLE ASSET MANAGEMENT L.P. | 38,225 | 1,595,000 | 0.24% | ||
| 43 | TIAA CREF INVESTMENT MANAGEMENT LLC | 37,988 | 1,585,000 | 0.24% | ||
| 44 | BARCLAYS PLC | 35,300 | 1,447,000 | 0.22% | Call | |
| 45 | TD ASSET MANAGEMENT INC | 33,787 | 1,410,000 | 0.21% | ||
| 46 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 33,256 | 1,388,000 | 0.21% | ||
| 47 | ArrowMark Colorado Holdings LLC | 32,512 | 1,357,000 | 0.20% | ||
| 48 | BNP Paribas Asset Management Holding S.A. | 29,804 | 1,244,000 | 0.19% | ||
| 49 | BlackRock Investment Management, LLC | 27,112 | 1,131,000 | 0.17% | ||
| 50 | DEUTSCHE BANK AG\ | 21,674 | 903,000 | 0.14% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
