| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 4,019,544 | 182,126,000 | 21.47% | ||
| 2 | PRICE T ROWE ASSOCIATES INC /MD/ | 2,052,928 | 93,018,000 | 10.97% | ||
| 3 | BAKER BROS. ADVISORS LP | 1,262,382 | 57,199,000 | 6.74% | ||
| 4 | VANGUARD GROUP INC | 1,094,738 | 49,603,000 | 5.85% | ||
| 5 | FEDERATED HERMES, INC. | 943,010 | 42,728,000 | 5.04% | ||
| 6 | LORD, ABBETT & CO. LLC | 651,495 | 29,520,000 | 3.48% | ||
| 7 | Clearbridge Investments, LLC | 641,730 | 29,077,000 | 3.43% | ||
| 8 | JPMORGAN CHASE & CO | 592,561 | 26,848,000 | 3.17% | ||
| 9 | Rock Springs Capital Management LP | 560,000 | 25,374,000 | 2.99% | ||
| 10 | Capital World Investors | 553,020 | 25,057,000 | 2.95% | ||
| 11 | BlackRock Fund Advisors | 488,435 | 22,131,000 | 2.61% | ||
| 12 | STATE STREET CORP | 486,871 | 22,060,000 | 2.60% | ||
| 13 | RS INVESTMENT MANAGEMENT CO LLC | 452,349 | 20,496,000 | 2.42% | ||
| 14 | Bain Capital Public Equity Management, LLC | 428,096 | 19,397,000 | 2.29% | ||
| 15 | WELLINGTON MANAGEMENT GROUP LLP | 421,000 | 19,075,000 | 2.25% | ||
| 16 | AMERICAN CENTURY COMPANIES INC | 419,203 | 18,994,000 | 2.24% | ||
| 17 | Invesco Ltd. | 349,700 | 15,845,000 | 1.87% | ||
| 18 | BlackRock Institutional Trust Company, N.A. | 270,408 | 12,252,000 | 1.44% | ||
| 19 | WADDELL & REED FINANCIAL INC | 207,685 | 9,410,000 | 1.11% | ||
| 20 | AMERIPRISE FINANCIAL INC | 175,532 | 7,952,000 | 0.94% | ||
| 21 | AXA S.A. | 162,310 | 7,354,000 | 0.87% | ||
| 22 | MORGAN STANLEY | 155,674 | 7,054,000 | 0.83% | ||
| 23 | EVENTIDE ASSET MANAGEMENT, LLC | 150,000 | 6,797,000 | 0.80% | ||
| 24 | CASDIN CAPITAL, LLC | 145,000 | 6,570,000 | 0.77% | ||
| 25 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 142,500 | 6,457,000 | 0.76% | ||
| 26 | EMERALD ADVISERS, LLC | 109,340 | 4,954,000 | 0.58% | ||
| 27 | NORGES BANK | 107,015 | 4,849,000 | 0.57% | ||
| 28 | OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 97,000 | 4,395,000 | 0.52% | ||
| 29 | NORTHERN TRUST CORP | 96,935 | 4,392,000 | 0.52% | ||
| 30 | GEODE CAPITAL MANAGEMENT, LLC | 92,276 | 4,181,000 | 0.49% | ||
| 31 | EMERALD MUTUAL FUND ADVISERS TRUST | 90,660 | 4,108,000 | 0.48% | ||
| 32 | D. E. Shaw & Co., Inc. | 82,099 | 3,720,000 | 0.44% | ||
| 33 | C WorldWide Group Holding A/S | 78,620 | 3,562,000 | 0.42% | ||
| 34 | BARCLAYS PLC | 75,000 | 3,375,000 | 0.40% | Call | |
| 35 | TD ASSET MANAGEMENT INC | 58,187 | 2,636,000 | 0.31% | ||
| 36 | Bank of New York Mellon Corp | 56,968 | 2,582,000 | 0.30% | ||
| 37 | TIAA CREF INVESTMENT MANAGEMENT LLC | 51,998 | 2,356,000 | 0.28% | ||
| 38 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 47,344 | 2,145,000 | 0.25% | ||
| 39 | MARINER INVESTMENT GROUP LLC | 44,350 | 2,009,000 | 0.24% | ||
| 40 | TOCQUEVILLE ASSET MANAGEMENT L.P. | 44,325 | 2,008,000 | 0.24% | ||
| 41 | TUDOR INVESTMENT CORP ET AL | 42,530 | 1,927,000 | 0.23% | ||
| 42 | GOLDMAN SACHS GROUP INC | 42,200 | 1,912,000 | 0.23% | Put | |
| 43 | GOLDMAN SACHS GROUP INC | 40,400 | 1,831,000 | 0.22% | Call | |
| 44 | Candriam S.C.A. | 40,000 | 1,812,000 | 0.21% | ||
| 45 | UBS Group AG | 36,296 | 1,645,000 | 0.19% | ||
| 46 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 34,539 | 1,565,000 | 0.18% | ||
| 47 | ALLIANCEBERNSTEIN L.P. | 36,700 | 1,531,000 | 0.18% | ||
| 48 | ALPS ADVISORS INC | 32,555 | 1,475,000 | 0.17% | ||
| 49 | BNP Paribas Asset Management Holding S.A. | 29,196 | 1,323,000 | 0.16% | ||
| 50 | BlackRock Investment Management, LLC | 27,119 | 1,229,000 | 0.14% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
