| 1 |
Essex Woodlands Management, Inc. |
3,231,656 |
44,597,000 |
25.98% |
|
|
| 2 |
DISCOVERY GROUP I, LLC |
1,935,809 |
26,714,000 |
15.56% |
|
|
| 3 |
PRICE T ROWE ASSOCIATES INC /MD/ |
1,188,524 |
16,402,000 |
9.56% |
|
|
| 4 |
FMR LLC |
569,336 |
7,857,000 |
4.58% |
|
|
| 5 |
ArrowMark Colorado Holdings LLC |
482,626 |
6,660,000 |
3.88% |
|
|
| 6 |
FRONTIER CAPITAL MANAGEMENT CO LLC |
468,417 |
6,464,000 |
3.77% |
|
|
| 7 |
KINGDON CAPITAL MANAGEMENT, L.L.C. |
450,371 |
6,215,000 |
3.62% |
|
|
| 8 |
BlackRock Finance, Inc. |
430,482 |
5,940,000 |
3.46% |
|
|
| 9 |
VANGUARD GROUP INC |
424,823 |
5,862,000 |
3.42% |
|
|
| 10 |
Cortina Asset Management, LLC |
412,323 |
5,690,000 |
3.32% |
|
|
| 11 |
Archon Capital Management LLC |
356,649 |
4,922,000 |
2.87% |
|
|
| 12 |
MILLENNIUM MANAGEMENT LLC |
351,981 |
4,857,000 |
2.83% |
|
|
| 13 |
INTERNATIONAL BIOTECHNOLOGY TRUST PLC |
341,468 |
4,702,000 |
2.74% |
|
|
| 14 |
WADDELL & REED FINANCIAL INC |
243,977 |
3,367,000 |
1.96% |
|
|
| 15 |
FEDERATED HERMES, INC. |
220,100 |
3,037,000 |
1.77% |
|
|
| 16 |
WASATCH ADVISORS LP |
217,194 |
2,997,000 |
1.75% |
|
|
| 17 |
ROYCE & ASSOCIATES LP |
167,000 |
2,305,000 |
1.34% |
|
|
| 18 |
Laurion Capital Management LP |
124,133 |
1,713,000 |
1.00% |
|
|
| 19 |
STATE STREET CORP |
111,470 |
1,537,000 |
0.90% |
|
|
| 20 |
NORTHERN TRUST CORP |
109,361 |
1,509,000 |
0.88% |
|
|
| 21 |
GEODE CAPITAL MANAGEMENT, LLC |
97,417 |
1,344,000 |
0.78% |
|
|
| 22 |
BLAIR WILLIAM & CO/IL |
89,050 |
1,229,000 |
0.72% |
|
|
| 23 |
PERKINS CAPITAL MANAGEMENT INC |
60,017 |
828,000 |
0.48% |
|
|
| 24 |
Bank of New York Mellon Corp |
31,513 |
434,000 |
0.25% |
|
|
| 25 |
GOLDMAN SACHS GROUP INC |
30,680 |
423,000 |
0.25% |
|
|
| 26 |
KEYBANK NATIONAL ASSOCIATION/OH |
29,359 |
405,000 |
0.24% |
|
|
| 27 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
28,330 |
391,000 |
0.23% |
|
|
| 28 |
NICHOLAS COMPANY, INC. |
21,495 |
296,000 |
0.17% |
|
|
| 29 |
CITADEL ADVISORS LLC |
20,994 |
290,000 |
0.17% |
|
|
| 30 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
20,577 |
284,000 |
0.17% |
|
|
| 31 |
TD ASSET MANAGEMENT INC |
20,183 |
279,000 |
0.16% |
|
|
| 32 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
17,017 |
235,000 |
0.14% |
|
|
| 33 |
RENAISSANCE TECHNOLOGIES LLC |
13,900 |
192,000 |
0.11% |
|
|
| 34 |
TEACHERS ADVISORS, LLC |
12,369 |
171,000 |
0.10% |
|
|
| 35 |
KOPP INVESTMENT ADVISORS LLC |
11,819 |
163,000 |
0.09% |
|
|
| 36 |
MORGAN STANLEY |
11,067 |
153,000 |
0.09% |
|
|
| 37 |
PARAMETRIC PORTFOLIO ASSOCIATES LLC |
10,888 |
150,000 |
0.09% |
|
|
| 38 |
NEW YORK STATE COMMON RETIREMENT FUND |
10,401 |
144,000 |
0.08% |
|
|
| 39 |
PARAGON ASSOCIATES & PARAGON ASSOCIATES II JOINT VENTURE |
10,000 |
138,000 |
0.08% |
|
|
| 40 |
ARDSLEY ADVISORY PARTNERS LP |
10,000 |
138,000 |
0.08% |
|
|
| 41 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
7,348 |
102,000 |
0.06% |
|
|
| 42 |
BANK OF AMERICA CORP /DE/ |
7,418 |
102,000 |
0.06% |
|
|
| 43 |
WELLS FARGO & COMPANY/MN |
6,583 |
90,000 |
0.05% |
|
|
| 44 |
FIRST MERCANTILE TRUST CO |
5,649 |
78,000 |
0.05% |
|
|
| 45 |
AMERICAN INTERNATIONAL GROUP, INC. |
4,654 |
64,000 |
0.04% |
|
|
| 46 |
Nationwide Fund Advisors |
4,268 |
59,000 |
0.03% |
|
|
| 47 |
DEUTSCHE BANK AG\ |
1,836 |
25,000 |
0.01% |
|
|
| 48 |
BARCLAYS PLC |
1,589 |
22,000 |
0.01% |
|
|
| 49 |
ROYAL BANK OF CANADA |
1,486 |
21,000 |
0.01% |
|
|
| 50 |
Legal & General Group Plc |
1,211 |
17,000 |
0.01% |
|
|
