| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Artal Group S.A. | 57,517,977 | 824,807,000 | 50.20% | ||
| 2 | FMR LLC | 15,647,859 | 224,390,000 | 13.66% | ||
| 3 | BlackRock Finance, Inc. | 4,858,490 | 69,670,000 | 4.24% | ||
| 4 | Ulys, L.L.C. | 4,321,214 | 61,966,000 | 3.77% | ||
| 5 | VANGUARD GROUP INC | 4,168,301 | 59,773,000 | 3.64% | ||
| 6 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 4,089,419 | 58,642,269 | 3.57% | ||
| 7 | EAGLE ASSET MANAGEMENT INC | 2,852,309 | 40,902,000 | 2.49% | ||
| 8 | NEA Management Company, LLC | 2,382,286 | 34,162,000 | 2.08% | ||
| 9 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 1,690,273 | 24,239,000 | 1.48% | ||
| 10 | STATE STREET CORP | 1,641,167 | 23,536,000 | 1.43% | ||
| 11 | NORGES BANK | 1,148,479 | 16,469,000 | 1.00% | ||
| 12 | LOOMIS SAYLES & CO L P | 913,833 | 13,104,000 | 0.80% | ||
| 13 | BALYASNY ASSET MANAGEMENT L.P. | 731,985 | 10,497,000 | 0.64% | ||
| 14 | CLEARBRIDGE, LLC | 720,030 | 10,325,000 | 0.63% | ||
| 15 | VOYA INVESTMENT MANAGEMENT LLC | 719,232 | 10,314,000 | 0.63% | ||
| 16 | COLUMBUS CIRCLE INVESTORS | 696,779 | 9,992,000 | 0.61% | ||
| 17 | NORTHERN TRUST CORP | 595,008 | 8,532,000 | 0.52% | ||
| 18 | TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 558,729 | 8,012,000 | 0.49% | ||
| 19 | HIGHBRIDGE CAPITAL MANAGEMENT LLC | 544,812 | 7,813,000 | 0.48% | ||
| 20 | ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 514,658 | 7,380,000 | 0.45% | ||
| 21 | GEODE CAPITAL MANAGEMENT, LLC | 433,420 | 6,215,000 | 0.38% | ||
| 22 | Invesco Ltd. | 426,534 | 6,116,000 | 0.37% | ||
| 23 | Jupiter Investment Management Ltd | 421,242 | 6,040,000 | 0.37% | ||
| 24 | BANK OF AMERICA CORP /DE/ | 391,019 | 5,607,000 | 0.34% | ||
| 25 | Point72 Asset Management, L.P. | 382,500 | 5,485,000 | 0.33% | ||
| 26 | SECTOR GAMMA AS | 332,300 | 4,765,000 | 0.29% | ||
| 27 | Bank of New York Mellon Corp | 280,253 | 4,018,000 | 0.24% | ||
| 28 | WELLINGTON MANAGEMENT GROUP LLP | 279,874 | 4,013,000 | 0.24% | ||
| 29 | JPMORGAN CHASE & CO | 277,556 | 3,980,000 | 0.24% | ||
| 30 | RENAISSANCE TECHNOLOGIES LLC | 261,505 | 3,750,000 | 0.23% | ||
| 31 | Candriam S.C.A. | 260,000 | 3,729,000 | 0.23% | ||
| 32 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 228,700 | 3,280,000 | 0.20% | Put | |
| 33 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 191,685 | 2,749,000 | 0.17% | ||
| 34 | ALLIANCEBERNSTEIN L.P. | 189,492 | 2,717,000 | 0.17% | ||
| 35 | MILLENNIUM MANAGEMENT LLC | 184,845 | 2,651,000 | 0.16% | ||
| 36 | MORGAN STANLEY | 174,765 | 2,505,000 | 0.15% | ||
| 37 | D. E. Shaw & Co., Inc. | 168,494 | 2,416,000 | 0.15% | ||
| 38 | TIAA CREF INVESTMENT MANAGEMENT LLC | 153,983 | 2,208,000 | 0.13% | ||
| 39 | DEUTSCHE BANK AG\ | 135,092 | 1,936,000 | 0.12% | ||
| 40 | UBS Group AG | 130,870 | 1,876,000 | 0.11% | ||
| 41 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 114,556 | 1,643,000 | 0.10% | ||
| 42 | GOLDMAN SACHS GROUP INC | 113,664 | 1,629,000 | 0.10% | ||
| 43 | WELLS FARGO & COMPANY/MN | 97,024 | 1,391,000 | 0.08% | ||
| 44 | BANK OF MONTREAL /CAN/ | 94,956 | 1,362,000 | 0.08% | ||
| 45 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 94,900 | 1,361,000 | 0.08% | Call | |
| 46 | CREDIT SUISSE AG/ | 92,548 | 1,327,000 | 0.08% | ||
| 47 | GSA CAPITAL PARTNERS LLP | 92,386 | 1,325,000 | 0.08% | ||
| 48 | VIRGINIA RETIREMENT SYSTEMS ET Al | 88,200 | 1,265,000 | 0.08% | ||
| 49 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 83,227 | 1,193,000 | 0.07% | ||
| 50 | Swiss National Bank | 80,014 | 1,147,000 | 0.07% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
