| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 4,783,754 | 191,302,000 | 13.73% | ||
| 2 | WELLINGTON MANAGEMENT GROUP LLP | 3,821,584 | 152,826,000 | 10.97% | ||
| 3 | BVF INC/IL | 2,102,280 | 84,070,000 | 6.03% | ||
| 4 | BlackRock Finance, Inc. | 2,052,435 | 82,078,000 | 5.89% | ||
| 5 | PRICE T ROWE ASSOCIATES INC /MD/ | 2,014,649 | 80,566,000 | 5.78% | ||
| 6 | LORD, ABBETT & CO. LLC | 1,720,266 | 68,793,000 | 4.94% | ||
| 7 | DEERFIELD MANAGEMENT COMPANY, L.P. | 1,365,000 | 54,586,000 | 3.92% | ||
| 8 | VANGUARD GROUP INC | 1,220,446 | 48,806,000 | 3.50% | ||
| 9 | PFM Health Sciences, LP | 1,052,012 | 42,070,000 | 3.02% | ||
| 10 | ALLIANCEBERNSTEIN L.P. | 972,699 | 38,898,000 | 2.79% | ||
| 11 | DRIEHAUS CAPITAL MANAGEMENT LLC | 891,691 | 35,659,000 | 2.56% | ||
| 12 | Opaleye Management Inc. | 880,000 | 35,191,000 | 2.53% | ||
| 13 | STATE STREET CORP | 791,739 | 31,663,000 | 2.27% | ||
| 14 | BOXER CAPITAL, LLC | 770,159 | 30,799,000 | 2.21% | ||
| 15 | VICTORY CAPITAL MANAGEMENT INC | 757,702 | 30,301,000 | 2.17% | ||
| 16 | HILLHOUSE INVESTMENT MANAGEMENT, LTD. | 733,245 | 29,322,000 | 2.10% | ||
| 17 | OppenheimerFunds, Inc. | 645,397 | 25,810,000 | 1.85% | ||
| 18 | Cormorant Asset Management, LP | 600,000 | 23,994,000 | 1.72% | ||
| 19 | SANDIA HOLDINGS, LLC | 492,341 | 19,689,000 | 1.41% | ||
| 20 | PERCEPTIVE ADVISORS LLC | 461,642 | 18,461,000 | 1.33% | ||
| 21 | Redmile Group, LLC | 400,000 | 15,996,000 | 1.15% | ||
| 22 | PICTET ASSET MANAGEMENT LTD | 358,866 | 14,351,000 | 1.03% | ||
| 23 | GOLDMAN SACHS GROUP INC | 353,556 | 14,139,000 | 1.01% | ||
| 24 | NORTHERN TRUST CORP | 306,501 | 12,257,000 | 0.88% | ||
| 25 | CASDIN CAPITAL, LLC | 294,500 | 11,777,000 | 0.85% | ||
| 26 | EVENTIDE ASSET MANAGEMENT, LLC | 265,000 | 10,597,000 | 0.76% | ||
| 27 | FORESITE CAPITAL MANAGEMENT III, LLC | 260,400 | 10,413,000 | 0.75% | ||
| 28 | GEODE CAPITAL MANAGEMENT, LLC | 254,026 | 10,158,000 | 0.73% | ||
| 29 | FRANKLIN RESOURCES INC | 200,000 | 7,998,000 | 0.57% | ||
| 30 | MONASHEE INVESTMENT MANAGEMENT LLC | 175,000 | 6,998,000 | 0.50% | PRN | |
| 31 | CADIAN CAPITAL MANAGEMENT, LP | 174,900 | 6,994,000 | 0.50% | ||
| 32 | FIL Ltd | 172,497 | 6,898,000 | 0.50% | ||
| 33 | CITADEL ADVISORS LLC | 171,574 | 6,861,000 | 0.49% | ||
| 34 | Avoro Capital Advisors LLC | 165,000 | 6,598,000 | 0.47% | ||
| 35 | JENNISON ASSOCIATES LLC | 150,000 | 5,998,000 | 0.43% | ||
| 36 | TWO SIGMA INVESTMENTS, LP | 148,105 | 5,923,000 | 0.43% | ||
| 37 | JPMORGAN CHASE & CO | 144,725 | 5,788,000 | 0.42% | ||
| 38 | PointState Capital LP | 129,500 | 5,179,000 | 0.37% | ||
| 39 | GREAT POINT PARTNERS LLC | 122,129 | 4,884,000 | 0.35% | ||
| 40 | Bank of New York Mellon Corp | 120,568 | 4,822,000 | 0.35% | ||
| 41 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 112,458 | 4,498,000 | 0.32% | ||
| 42 | MORGAN STANLEY | 109,668 | 4,386,000 | 0.31% | ||
| 43 | Point72 Asset Management, L.P. | 103,000 | 4,119,000 | 0.30% | ||
| 44 | Ghost Tree Capital, LLC | 100,000 | 3,999,000 | 0.29% | ||
| 45 | Spark Investment Management LLC | 89,800 | 3,591,000 | 0.26% | ||
| 46 | DAFNA Capital Management LLC | 82,500 | 3,299,000 | 0.24% | ||
| 47 | TIAA CREF INVESTMENT MANAGEMENT LLC | 63,428 | 2,536,000 | 0.18% | ||
| 48 | Alyeska Investment Group, L.P. | 59,746 | 2,389,000 | 0.17% | ||
| 49 | NBW CAPITAL LLC | 59,356 | 2,374,000 | 0.17% | ||
| 50 | Laurion Capital Management LP | 50,006 | 2,000,000 | 0.14% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
