| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 5,300,589 | 268,581,000 | 14.76% | ||
| 2 | WELLINGTON MANAGEMENT GROUP LLP | 3,109,697 | 157,567,000 | 8.66% | ||
| 3 | BlackRock Finance, Inc. | 2,864,255 | 145,131,000 | 7.98% | ||
| 4 | PRICE T ROWE ASSOCIATES INC /MD/ | 2,473,985 | 125,357,000 | 6.89% | ||
| 5 | LORD, ABBETT & CO. LLC | 1,729,169 | 87,617,000 | 4.82% | ||
| 6 | BVF INC/IL | 1,591,646 | 80,649,000 | 4.43% | ||
| 7 | OppenheimerFunds, Inc. | 1,525,002 | 77,272,000 | 4.25% | ||
| 8 | VANGUARD GROUP INC | 1,415,963 | 71,746,000 | 3.94% | ||
| 9 | STATE STREET CORP | 1,400,035 | 70,936,000 | 3.90% | ||
| 10 | PFM Health Sciences, LP | 1,286,450 | 65,184,000 | 3.58% | ||
| 11 | ALLIANCEBERNSTEIN L.P. | 1,074,629 | 54,451,000 | 2.99% | ||
| 12 | Opaleye Management Inc. | 880,000 | 44,589,000 | 2.45% | ||
| 13 | VICTORY CAPITAL MANAGEMENT INC | 587,052 | 29,746,000 | 1.63% | ||
| 14 | HILLHOUSE INVESTMENT MANAGEMENT, LTD. | 583,245 | 29,553,000 | 1.62% | ||
| 15 | DRIEHAUS CAPITAL MANAGEMENT LLC | 566,777 | 28,719,000 | 1.58% | ||
| 16 | TimesSquare Capital Management, LLC | 560,000 | 28,375,000 | 1.56% | ||
| 17 | NORTHERN TRUST CORP | 473,545 | 23,995,000 | 1.32% | ||
| 18 | FORESITE CAPITAL MANAGEMENT III, LLC | 460,000 | 23,308,000 | 1.28% | ||
| 19 | CADIAN CAPITAL MANAGEMENT, LP | 457,102 | 23,161,000 | 1.27% | ||
| 20 | PERCEPTIVE ADVISORS LLC | 444,661 | 22,530,000 | 1.24% | ||
| 21 | Point72 Asset Management, L.P. | 398,108 | 20,172,000 | 1.11% | ||
| 22 | NORGES BANK | 375,000 | 19,001,000 | 1.04% | ||
| 23 | Cormorant Asset Management, LP | 367,900 | 18,641,000 | 1.02% | SH | |
| 24 | Redmile Group, LLC | 367,537 | 18,623,000 | 1.02% | ||
| 25 | GEODE CAPITAL MANAGEMENT, LLC | 316,092 | 16,016,000 | 0.88% | ||
| 26 | SANDIA HOLDINGS, LLC | 303,641 | 15,385,000 | 0.85% | ||
| 27 | CITADEL ADVISORS LLC | 290,782 | 14,734,000 | 0.81% | ||
| 28 | CASDIN CAPITAL, LLC | 275,000 | 13,934,000 | 0.77% | ||
| 29 | EVENTIDE ASSET MANAGEMENT, LLC | 265,000 | 13,428,000 | 0.74% | ||
| 30 | BOXER CAPITAL, LLC | 250,000 | 12,668,000 | 0.70% | ||
| 31 | Numeric Investors LLC | 240,871 | 12,205,000 | 0.67% | ||
| 32 | TEACHERS ADVISORS, LLC | 239,573 | 12,139,000 | 0.67% | ||
| 33 | JENNISON ASSOCIATES LLC | 229,142 | 11,611,000 | 0.64% | ||
| 34 | GOLDMAN SACHS GROUP INC | 210,792 | 10,681,000 | 0.59% | ||
| 35 | PICTET ASSET MANAGEMENT LTD | 296,438 | 10,636,000 | 0.58% | ||
| 36 | DEERFIELD MANAGEMENT COMPANY, L.P. | 203,000 | 10,286,000 | 0.57% | ||
| 37 | Bank of New York Mellon Corp | 174,703 | 8,853,000 | 0.49% | ||
| 38 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 155,306 | 7,870,000 | 0.43% | ||
| 39 | TIAA CREF INVESTMENT MANAGEMENT LLC | 121,941 | 6,179,000 | 0.34% | ||
| 40 | Spark Investment Management LLC | 89,800 | 4,550,000 | 0.25% | ||
| 41 | DAFNA Capital Management LLC | 82,000 | 4,155,000 | 0.23% | ||
| 42 | DEUTSCHE BANK AG\ | 81,989 | 4,150,000 | 0.23% | ||
| 43 | PRUDENTIAL FINANCIAL INC | 74,404 | 3,770,000 | 0.21% | ||
| 44 | Ghost Tree Capital, LLC | 70,000 | 3,547,000 | 0.19% | ||
| 45 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 68,861 | 3,489,000 | 0.19% | ||
| 46 | PAULSON & CO. INC. | 65,800 | 3,334,000 | 0.18% | ||
| 47 | TWO SIGMA INVESTMENTS, LP | 63,477 | 3,216,000 | 0.18% | ||
| 48 | FIRST TRUST ADVISORS LP | 57,681 | 2,923,000 | 0.16% | ||
| 49 | AQR CAPITAL MANAGEMENT LLC | 55,595 | 2,817,000 | 0.15% | ||
| 50 | Nationwide Fund Advisors | 51,534 | 2,611,000 | 0.14% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
