| 1 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
3,732,412 |
17,169,000 |
29.57% |
|
|
| 2 |
BVF INC/IL |
1,926,443 |
8,862,000 |
15.26% |
|
|
| 3 |
WELLINGTON MANAGEMENT GROUP LLP |
1,531,622 |
7,045,000 |
12.13% |
|
|
| 4 |
TIGER MANAGEMENT L.L.C. |
650,915 |
2,994,000 |
5.16% |
|
|
| 5 |
SABBY MANAGEMENT, LLC |
641,492 |
2,951,000 |
5.08% |
|
|
| 6 |
KINGDON CAPITAL MANAGEMENT, L.L.C. |
541,700 |
2,492,000 |
4.29% |
|
|
| 7 |
AXA S.A. |
533,692 |
2,455,000 |
4.23% |
|
|
| 8 |
JENNISON ASSOCIATES LLC |
492,737 |
2,267,000 |
3.90% |
|
|
| 9 |
FRANKLIN RESOURCES INC |
490,000 |
2,254,000 |
3.88% |
|
|
| 10 |
Rock Springs Capital Management LP |
489,000 |
2,249,000 |
3.87% |
|
|
| 11 |
VANGUARD GROUP INC |
255,420 |
1,175,000 |
2.02% |
|
|
| 12 |
WALL STREET ASSOCIATES |
170,400 |
784,000 |
1.35% |
|
|
| 13 |
ASCEND CAPITAL, LLC |
150,000 |
690,000 |
1.19% |
|
|
| 14 |
EverPoint Asset Management, LLC |
125,000 |
575,000 |
0.99% |
|
|
| 15 |
PERCEPTIVE ADVISORS LLC |
125,000 |
575,000 |
0.99% |
|
|
| 16 |
FMR LLC |
100,000 |
460,000 |
0.79% |
|
|
| 17 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
75,000 |
345,000 |
0.59% |
|
|
| 18 |
ACADIAN ASSET MANAGEMENT LLC |
71,777 |
330,000 |
0.57% |
|
|
| 19 |
Alyeska Investment Group, L.P. |
67,408 |
310,000 |
0.53% |
|
|
| 20 |
Endurant Capital Management LP |
65,783 |
303,000 |
0.52% |
|
|
| 21 |
BlackRock Institutional Trust Company, N.A. |
56,859 |
262,000 |
0.45% |
|
|
| 22 |
D. E. Shaw & Co., Inc. |
42,605 |
196,000 |
0.34% |
|
|
| 23 |
GEODE CAPITAL MANAGEMENT, LLC |
33,457 |
153,000 |
0.26% |
|
|
| 24 |
RTW INVESTMENTS, LP |
30,000 |
138,000 |
0.24% |
|
|
| 25 |
GOLDMAN SACHS GROUP INC |
27,324 |
126,000 |
0.22% |
|
|
| 26 |
BlackRock Fund Advisors |
24,976 |
115,000 |
0.20% |
|
|
| 27 |
Paloma Partners Management Co |
22,681 |
105,000 |
0.18% |
|
|
| 28 |
MSI Financial Services Inc |
20,000 |
92,000 |
0.16% |
|
|
| 29 |
MORGAN STANLEY |
17,291 |
79,000 |
0.14% |
|
|
| 30 |
DEUTSCHE BANK AG\ |
17,263 |
79,000 |
0.14% |
|
|
| 31 |
EMERALD ACQUISITION LTD. |
15,339 |
70,000 |
0.12% |
|
|
| 32 |
Bank of New York Mellon Corp |
15,305 |
70,000 |
0.12% |
|
|
| 33 |
DAFNA Capital Management LLC |
15,000 |
69,000 |
0.12% |
|
|
| 34 |
STONERIDGE INVESTMENT PARTNERS LLC |
13,631 |
63,000 |
0.11% |
|
|
| 35 |
NORTHERN TRUST CORP |
10,120 |
47,000 |
0.08% |
|
|
| 36 |
NEW YORK STATE COMMON RETIREMENT FUND |
7,148 |
33,000 |
0.06% |
|
|
| 37 |
BARCLAYS PLC |
4,097 |
18,000 |
0.03% |
|
|
| 38 |
BANK OF AMERICA CORP /DE/ |
3,780 |
17,000 |
0.03% |
|
|
| 39 |
BlackRock Japan Co. Ltd |
2,797 |
13,000 |
0.02% |
|
|
| 40 |
Tower Research Capital LLC (TRC) |
2,505 |
12,000 |
0.02% |
|
|
| 41 |
BlackRock Investment Management, LLC |
1,775 |
8,000 |
0.01% |
|
|
| 42 |
BLACKROCK ADVISORS LLC |
1,825 |
8,000 |
0.01% |
|
|
| 43 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
948 |
4,000 |
0.01% |
|
|
| 44 |
Creative Planning |
478 |
2,000 |
0.00% |
|
|
| 45 |
JPMORGAN CHASE & CO |
294 |
1,000 |
0.00% |
|
|
| 46 |
WOLVERINE TRADING LP /BD |
40 |
180 |
0.00% |
|
|
| 47 |
UBS Group AG |
9 |
0 |
0.00% |
|
|
| 48 |
MAGEE THOMSON INVESTMENT PARTNERS LLC |
108 |
0 |
0.00% |
|
|
