| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | DEERFIELD MANAGEMENT COMPANY, L.P. | 3,732,412 | 48,409,000 | 27.97% | ||
| 2 | WELLINGTON MANAGEMENT GROUP LLP | 2,163,254 | 28,058,000 | 16.21% | ||
| 3 | TIGER MANAGEMENT L.L.C. | 650,915 | 8,442,000 | 4.88% | ||
| 4 | RA CAPITAL MANAGEMENT, L.P. | 612,863 | 7,949,000 | 4.59% | ||
| 5 | JENNISON ASSOCIATES LLC | 551,546 | 7,071,000 | 4.09% | ||
| 6 | Rock Springs Capital Management LP | 489,000 | 6,342,000 | 3.66% | ||
| 7 | FRANKLIN RESOURCES INC | 456,300 | 5,918,000 | 3.42% | ||
| 8 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 418,903 | 5,433,000 | 3.14% | ||
| 9 | SABBY MANAGEMENT, LLC | 384,734 | 4,990,000 | 2.88% | ||
| 10 | GOLDMAN SACHS GROUP INC | 373,170 | 4,840,000 | 2.80% | ||
| 11 | AXA S.A. | 339,748 | 4,407,000 | 2.55% | ||
| 12 | JPMORGAN CHASE & CO | 332,971 | 4,319,000 | 2.50% | ||
| 13 | MARSICO CAPITAL MANAGEMENT LLC | 288,955 | 3,748,000 | 2.17% | ||
| 14 | LORD, ABBETT & CO. LLC | 258,615 | 3,354,000 | 1.94% | ||
| 15 | SPHERA FUNDS MANAGEMENT LTD. | 201,720 | 2,616,000 | 1.51% | ||
| 16 | VANGUARD GROUP INC | 199,879 | 2,592,000 | 1.50% | ||
| 17 | Opaleye Management Inc. | 175,200 | 2,272,000 | 1.31% | ||
| 18 | GLG LLC | 171,959 | 2,230,000 | 1.29% | ||
| 19 | WALL STREET ASSOCIATES | 170,400 | 2,210,000 | 1.28% | ||
| 20 | DRIEHAUS CAPITAL MANAGEMENT LLC | 162,094 | 2,102,000 | 1.21% | ||
| 21 | PERCEPTIVE ADVISORS LLC | 125,000 | 1,621,000 | 0.94% | ||
| 22 | BlackRock Fund Advisors | 119,859 | 1,555,000 | 0.90% | ||
| 23 | FEDERATED HERMES, INC. | 110,137 | 1,428,000 | 0.83% | ||
| 24 | FMR LLC | 100,000 | 1,297,000 | 0.75% | ||
| 25 | BlackRock Institutional Trust Company, N.A. | 70,024 | 908,000 | 0.52% | ||
| 26 | AMERIPRISE FINANCIAL INC | 62,515 | 811,000 | 0.47% | ||
| 27 | GLG Partners LP | 57,869 | 751,000 | 0.43% | ||
| 28 | FRED ALGER MANAGEMENT, LLC | 57,450 | 745,000 | 0.43% | ||
| 29 | Alyeska Investment Group, L.P. | 49,008 | 636,000 | 0.37% | ||
| 30 | D. E. Shaw & Co., Inc. | 43,263 | 561,000 | 0.32% | ||
| 31 | PANAGORA ASSET MANAGEMENT INC | 35,445 | 460,000 | 0.27% | ||
| 32 | MORGAN STANLEY | 35,011 | 454,000 | 0.26% | ||
| 33 | Endurant Capital Management LP | 30,284 | 393,000 | 0.23% | ||
| 34 | RTW INVESTMENTS, LP | 30,000 | 389,000 | 0.22% | ||
| 35 | BRIDGER MANAGEMENT, LLC | 33,159 | 381,000 | 0.22% | ||
| 36 | UNITED SERVICES AUTOMOBILE ASSOCIATION | 22,750 | 295,000 | 0.17% | ||
| 37 | Spark Investment Management LLC | 22,000 | 286,000 | 0.17% | ||
| 38 | GEODE CAPITAL MANAGEMENT, LLC | 21,399 | 277,000 | 0.16% | ||
| 39 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 20,363 | 264,000 | 0.15% | ||
| 40 | Nicholas Investment Partners, LP | 19,868 | 258,000 | 0.15% | ||
| 41 | Virtu KCG Holdings LLC | 16,033 | 208,000 | 0.12% | ||
| 42 | CREDIT SUISSE AG/ | 15,797 | 205,000 | 0.12% | ||
| 43 | BlackRock Investment Management, LLC | 15,334 | 199,000 | 0.11% | ||
| 44 | DAFNA Capital Management LLC | 15,000 | 195,000 | 0.11% | ||
| 45 | NORTHERN TRUST CORP | 14,371 | 186,000 | 0.11% | ||
| 46 | MILLENNIUM MANAGEMENT LLC | 14,289 | 185,000 | 0.11% | ||
| 47 | Bank of New York Mellon Corp | 12,092 | 157,000 | 0.09% | ||
| 48 | ASCEND CAPITAL, LLC | 11,897 | 156,000 | 0.09% | ||
| 49 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 9,200 | 119,000 | 0.07% | ||
| 50 | Tower Research Capital LLC (TRC) | 8,475 | 110,000 | 0.06% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
