| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | DEERFIELD MANAGEMENT COMPANY, L.P. | 3,732,412 | 30,345,000 | 30.30% | ||
| 2 | BVF INC/IL | 1,709,673 | 13,900,000 | 13.88% | ||
| 3 | WELLINGTON MANAGEMENT GROUP LLP | 1,523,489 | 12,385,000 | 12.37% | ||
| 4 | AXA S.A. | 651,846 | 5,300,000 | 5.29% | ||
| 5 | TIGER MANAGEMENT L.L.C. | 650,915 | 5,292,000 | 5.28% | ||
| 6 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 541,700 | 4,404,000 | 4.40% | ||
| 7 | FRANKLIN RESOURCES INC | 490,000 | 3,984,000 | 3.98% | ||
| 8 | Rock Springs Capital Management LP | 489,000 | 3,976,000 | 3.97% | ||
| 9 | JENNISON ASSOCIATES LLC | 328,763 | 2,673,000 | 2.67% | ||
| 10 | VANGUARD GROUP INC | 271,682 | 2,208,000 | 2.20% | ||
| 11 | SABBY MANAGEMENT, LLC | 267,650 | 2,176,000 | 2.17% | ||
| 12 | EverPoint Asset Management, LLC | 219,735 | 1,786,000 | 1.78% | ||
| 13 | SPHERA FUNDS MANAGEMENT LTD. | 204,700 | 1,664,000 | 1.66% | ||
| 14 | WALL STREET ASSOCIATES | 170,400 | 1,385,000 | 1.38% | ||
| 15 | GEODE CAPITAL MANAGEMENT, LLC | 127,485 | 1,036,000 | 1.03% | ||
| 16 | PERCEPTIVE ADVISORS LLC | 122,275 | 994,000 | 0.99% | ||
| 17 | FMR LLC | 100,000 | 813,000 | 0.81% | ||
| 18 | Endurant Capital Management LP | 85,412 | 694,000 | 0.69% | ||
| 19 | GOLDMAN SACHS GROUP INC | 77,023 | 626,000 | 0.63% | ||
| 20 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 75,000 | 610,000 | 0.61% | ||
| 21 | Alyeska Investment Group, L.P. | 70,204 | 571,000 | 0.57% | ||
| 22 | ORBIMED ADVISORS LLC | 59,000 | 480,000 | 0.48% | ||
| 23 | BlackRock Institutional Trust Company, N.A. | 56,859 | 462,000 | 0.46% | ||
| 24 | D. E. Shaw & Co., Inc. | 31,521 | 256,000 | 0.26% | ||
| 25 | RTW INVESTMENTS, LP | 30,000 | 244,000 | 0.24% | ||
| 26 | BlackRock Fund Advisors | 24,880 | 202,000 | 0.20% | ||
| 27 | MSI Financial Services Inc | 20,000 | 163,000 | 0.16% | ||
| 28 | ACADIAN ASSET MANAGEMENT LLC | 19,805 | 161,000 | 0.16% | ||
| 29 | Spark Investment Management LLC | 17,900 | 145,000 | 0.14% | ||
| 30 | Bank of New York Mellon Corp | 16,494 | 134,000 | 0.13% | ||
| 31 | DAFNA Capital Management LLC | 15,000 | 122,000 | 0.12% | ||
| 32 | STONERIDGE INVESTMENT PARTNERS LLC | 13,563 | 110,000 | 0.11% | ||
| 33 | TFS CAPITAL LLC | 13,116 | 107,000 | 0.11% | ||
| 34 | Virtu KCG Holdings LLC | 11,963 | 97,000 | 0.10% | ||
| 35 | MORGAN STANLEY | 11,847 | 96,000 | 0.10% | ||
| 36 | DEUTSCHE BANK AG\ | 11,287 | 91,000 | 0.09% | ||
| 37 | TLP GROUP LLC | 11,150 | 91,000 | 0.09% | ||
| 38 | NORTHERN TRUST CORP | 10,120 | 82,000 | 0.08% | ||
| 39 | ARDSLEY ADVISORY PARTNERS LP | 10,000 | 81,000 | 0.08% | ||
| 40 | NEW YORK STATE COMMON RETIREMENT FUND | 7,148 | 58,000 | 0.06% | ||
| 41 | BARCLAYS PLC | 4,000 | 33,000 | 0.03% | ||
| 42 | UBS Group AG | 2,119 | 17,000 | 0.02% | ||
| 43 | JPMORGAN CHASE & CO | 1,937 | 16,000 | 0.02% | ||
| 44 | BANK OF AMERICA CORP /DE/ | 1,811 | 15,000 | 0.01% | ||
| 45 | BlackRock Investment Management, LLC | 1,775 | 14,000 | 0.01% | ||
| 46 | BlackRock Japan Co. Ltd | 1,606 | 13,000 | 0.01% | ||
| 47 | BLACKROCK ADVISORS LLC | 1,611 | 13,000 | 0.01% | ||
| 48 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 948 | 8,000 | 0.01% | ||
| 49 | Creative Planning | 478 | 4,000 | 0.00% | ||
| 50 | MAGEE THOMSON INVESTMENT PARTNERS LLC | 126 | 1,000 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
