| 1 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
3,732,412 |
15,564,000 |
28.04% |
|
|
| 2 |
WELLINGTON MANAGEMENT GROUP LLP |
1,749,829 |
7,296,000 |
13.14% |
|
|
| 3 |
BVF INC/IL |
1,546,743 |
6,450,000 |
11.62% |
|
|
| 4 |
SABBY MANAGEMENT, LLC |
662,058 |
2,761,000 |
4.97% |
|
|
| 5 |
TIGER MANAGEMENT L.L.C. |
650,915 |
2,714,000 |
4.89% |
|
|
| 6 |
RA CAPITAL MANAGEMENT, L.P. |
612,863 |
2,556,000 |
4.60% |
|
|
| 7 |
JENNISON ASSOCIATES LLC |
492,719 |
2,055,000 |
3.70% |
|
|
| 8 |
FRANKLIN RESOURCES INC |
490,000 |
2,043,000 |
3.68% |
|
|
| 9 |
Rock Springs Capital Management LP |
489,000 |
2,039,000 |
3.67% |
|
|
| 10 |
AXA S.A. |
394,040 |
1,643,000 |
2.96% |
|
|
| 11 |
JPMORGAN CHASE & CO |
289,394 |
1,207,000 |
2.17% |
|
|
| 12 |
VANGUARD GROUP INC |
267,569 |
1,116,000 |
2.01% |
|
|
| 13 |
KINGDON CAPITAL MANAGEMENT, L.L.C. |
256,552 |
1,070,000 |
1.93% |
|
|
| 14 |
WALL STREET ASSOCIATES |
170,400 |
711,000 |
1.28% |
|
|
| 15 |
BlackRock Fund Advisors |
130,864 |
546,000 |
0.98% |
|
|
| 16 |
EverPoint Asset Management, LLC |
125,000 |
521,000 |
0.94% |
|
|
| 17 |
PERCEPTIVE ADVISORS LLC |
125,000 |
521,000 |
0.94% |
|
|
| 18 |
FMR LLC |
100,000 |
417,000 |
0.75% |
|
|
| 19 |
Opaleye Management Inc. |
100,000 |
417,000 |
0.75% |
|
|
| 20 |
BlackRock Institutional Trust Company, N.A. |
90,252 |
376,000 |
0.68% |
|
|
| 21 |
SPHERA FUNDS MANAGEMENT LTD. |
79,900 |
333,000 |
0.60% |
|
|
| 22 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
75,000 |
313,000 |
0.56% |
|
|
| 23 |
ACADIAN ASSET MANAGEMENT LLC |
71,702 |
299,000 |
0.54% |
|
|
| 24 |
Alyeska Investment Group, L.P. |
66,039 |
275,000 |
0.50% |
|
|
| 25 |
NORTHERN TRUST CORP |
51,369 |
214,000 |
0.39% |
|
|
| 26 |
ASCEND CAPITAL, LLC |
50,000 |
208,000 |
0.37% |
|
|
| 27 |
STATE STREET CORP |
44,495 |
186,000 |
0.34% |
|
|
| 28 |
D. E. Shaw & Co., Inc. |
43,029 |
179,000 |
0.32% |
|
|
| 29 |
GEODE CAPITAL MANAGEMENT, LLC |
33,567 |
139,000 |
0.25% |
|
|
| 30 |
RUSSELL FRANK CO/ |
32,145 |
134,000 |
0.24% |
|
|
| 31 |
Endurant Capital Management LP |
30,984 |
129,000 |
0.23% |
|
|
| 32 |
RTW INVESTMENTS, LP |
30,000 |
125,000 |
0.23% |
|
|
| 33 |
MORGAN STANLEY |
28,600 |
119,000 |
0.21% |
|
|
| 34 |
Bank of New York Mellon Corp |
23,119 |
97,000 |
0.17% |
|
|
| 35 |
GOLDMAN SACHS GROUP INC |
20,667 |
86,000 |
0.15% |
|
|
| 36 |
JACOBS LEVY EQUITY MANAGEMENT, INC |
20,104 |
84,000 |
0.15% |
|
|
| 37 |
BlackRock Investment Management, LLC |
16,075 |
67,000 |
0.12% |
|
|
| 38 |
DAFNA Capital Management LLC |
15,000 |
63,000 |
0.11% |
|
|
| 39 |
MSI Financial Services Inc |
15,000 |
63,000 |
0.11% |
|
|
| 40 |
STONERIDGE INVESTMENT PARTNERS LLC |
13,631 |
57,000 |
0.10% |
|
|
| 41 |
NEW YORK STATE COMMON RETIREMENT FUND |
12,348 |
51,000 |
0.09% |
|
|
| 42 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
10,663 |
44,000 |
0.08% |
|
|
| 43 |
Tower Research Capital LLC (TRC) |
10,186 |
43,000 |
0.08% |
|
|
| 44 |
Nationwide Fund Advisors |
9,873 |
41,000 |
0.07% |
|
|
| 45 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
8,476 |
35,000 |
0.06% |
|
|
| 46 |
TEACHERS ADVISORS, LLC |
4,804 |
20,000 |
0.04% |
|
|
| 47 |
CITIGROUP INC |
4,184 |
18,000 |
0.03% |
|
|
| 48 |
BARCLAYS PLC |
4,000 |
16,000 |
0.03% |
|
|
| 49 |
AMERICAN INTERNATIONAL GROUP, INC. |
2,881 |
12,000 |
0.02% |
|
|
| 50 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
2,129 |
9,000 |
0.02% |
|
|
