| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | DEERFIELD MANAGEMENT COMPANY, L.P. | 3,732,412 | 56,546,000 | 31.62% | ||
| 2 | WELLINGTON MANAGEMENT GROUP LLP | 1,646,700 | 24,553,000 | 13.73% | ||
| 3 | RA CAPITAL MANAGEMENT, L.P. | 757,263 | 11,473,000 | 6.42% | ||
| 4 | Rock Springs Capital Management LP | 564,358 | 8,550,000 | 4.78% | ||
| 5 | JENNISON ASSOCIATES LLC | 577,185 | 8,531,000 | 4.77% | ||
| 6 | SABBY MANAGEMENT, LLC | 430,041 | 6,515,000 | 3.64% | ||
| 7 | GOLDMAN SACHS GROUP INC | 392,514 | 5,947,000 | 3.33% | ||
| 8 | FRANKLIN RESOURCES INC | 350,000 | 5,303,000 | 2.97% | ||
| 9 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 325,000 | 4,924,000 | 2.75% | ||
| 10 | MARSICO CAPITAL MANAGEMENT LLC | 300,000 | 4,545,000 | 2.54% | ||
| 11 | JPMORGAN CHASE & CO | 294,593 | 4,463,000 | 2.50% | ||
| 12 | SPHERA FUNDS MANAGEMENT LTD. | 255,000 | 3,863,000 | 2.16% | ||
| 13 | AXA S.A. | 250,000 | 3,788,000 | 2.12% | ||
| 14 | LORD, ABBETT & CO. LLC | 240,817 | 3,649,000 | 2.04% | ||
| 15 | Lamond Capital Partners LLC | 225,000 | 3,409,000 | 1.91% | ||
| 16 | WALL STREET ASSOCIATES | 192,400 | 2,915,000 | 1.63% | ||
| 17 | GLG LLC | 183,107 | 2,774,000 | 1.55% | ||
| 18 | FEDERATED HERMES, INC. | 150,000 | 2,273,000 | 1.27% | ||
| 19 | BLACKROCK ADVISORS LLC | 132,700 | 2,010,000 | 1.12% | ||
| 20 | Pentwater Capital Management LP | 100,000 | 1,515,000 | 0.85% | ||
| 21 | FMR LLC | 100,000 | 1,515,000 | 0.85% | ||
| 22 | MONASHEE INVESTMENT MANAGEMENT LLC | 62,500 | 947,000 | 0.53% | PRN | |
| 23 | AMERIPRISE FINANCIAL INC | 62,515 | 947,000 | 0.53% | ||
| 24 | CQS Cayman LP | 60,000 | 909,000 | 0.51% | ||
| 25 | FRED ALGER MANAGEMENT, LLC | 57,450 | 870,000 | 0.49% | ||
| 26 | OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 50,000 | 758,000 | 0.42% | ||
| 27 | Ghost Tree Capital, LLC | 50,000 | 758,000 | 0.42% | ||
| 28 | Endurant Capital Management LP | 46,500 | 704,000 | 0.39% | ||
| 29 | VANGUARD GROUP INC | 39,936 | 605,000 | 0.34% | ||
| 30 | GLG Partners LP | 31,250 | 473,000 | 0.26% | ||
| 31 | RTW INVESTMENTS, LP | 30,000 | 455,000 | 0.25% | ||
| 32 | BRIDGER MANAGEMENT, LLC | 33,159 | 452,000 | 0.25% | ||
| 33 | C Partners Holding GmbH | 26,000 | 394,000 | 0.22% | ||
| 34 | Alyeska Investment Group, L.P. | 25,000 | 379,000 | 0.21% | ||
| 35 | SG Americas Securities, LLC | 20,000 | 303,000 | 0.17% | ||
| 36 | UNITED SERVICES AUTOMOBILE ASSOCIATION | 16,100 | 244,000 | 0.14% | ||
| 37 | DAFNA Capital Management LLC | 15,000 | 227,000 | 0.13% | ||
| 38 | Nicholas Investment Partners, LP | 12,669 | 192,000 | 0.11% | ||
| 39 | BlackRock Investment Management, LLC | 8,600 | 130,000 | 0.07% | ||
| 40 | NEW YORK STATE COMMON RETIREMENT FUND | 1,583 | 24,000 | 0.01% | ||
| 41 | DEUTSCHE BANK AG\ | 675 | 10,000 | 0.01% | ||
| 42 | MORGAN STANLEY | 1 | 0 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
