| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | DEERFIELD MANAGEMENT COMPANY, L.P. | 3,732,412 | 28,889,000 | 27.95% | ||
| 2 | WELLINGTON MANAGEMENT GROUP LLP | 1,811,453 | 14,021,000 | 13.57% | ||
| 3 | BVF INC/IL | 1,195,013 | 9,249,000 | 8.95% | ||
| 4 | TIGER MANAGEMENT L.L.C. | 650,915 | 5,038,000 | 4.87% | ||
| 5 | RA CAPITAL MANAGEMENT, L.P. | 612,863 | 4,744,000 | 4.59% | ||
| 6 | SABBY MANAGEMENT, LLC | 503,595 | 3,898,000 | 3.77% | ||
| 7 | JENNISON ASSOCIATES LLC | 491,936 | 3,808,000 | 3.68% | ||
| 8 | FRANKLIN RESOURCES INC | 490,000 | 3,793,000 | 3.67% | ||
| 9 | Rock Springs Capital Management LP | 489,000 | 3,785,000 | 3.66% | ||
| 10 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 399,663 | 3,093,000 | 2.99% | ||
| 11 | AXA S.A. | 394,040 | 3,050,000 | 2.95% | ||
| 12 | GOLDMAN SACHS GROUP INC | 369,858 | 2,863,000 | 2.77% | ||
| 13 | JPMORGAN CHASE & CO | 294,200 | 2,277,000 | 2.20% | ||
| 14 | VANGUARD GROUP INC | 262,975 | 2,035,000 | 1.97% | ||
| 15 | SPHERA FUNDS MANAGEMENT LTD. | 231,548 | 1,792,000 | 1.73% | ||
| 16 | WALL STREET ASSOCIATES | 170,400 | 1,319,000 | 1.28% | ||
| 17 | BlackRock Fund Advisors | 138,091 | 1,069,000 | 1.03% | ||
| 18 | MARSICO CAPITAL MANAGEMENT LLC | 136,431 | 1,056,000 | 1.02% | ||
| 19 | PERCEPTIVE ADVISORS LLC | 125,000 | 968,000 | 0.94% | ||
| 20 | FMR LLC | 100,000 | 774,000 | 0.75% | ||
| 21 | BlackRock Institutional Trust Company, N.A. | 92,891 | 719,000 | 0.70% | ||
| 22 | ACADIAN ASSET MANAGEMENT LLC | 75,675 | 587,000 | 0.57% | ||
| 23 | NORTHERN TRUST CORP | 51,369 | 397,000 | 0.38% | ||
| 24 | Alyeska Investment Group, L.P. | 50,674 | 392,000 | 0.38% | ||
| 25 | Spark Investment Management LLC | 43,000 | 332,000 | 0.32% | ||
| 26 | STATE STREET CORP | 42,595 | 330,000 | 0.32% | ||
| 27 | GLG Partners LP | 38,756 | 300,000 | 0.29% | ||
| 28 | FRED ALGER MANAGEMENT, LLC | 37,100 | 287,000 | 0.28% | ||
| 29 | D. E. Shaw & Co., Inc. | 35,878 | 278,000 | 0.27% | ||
| 30 | GEODE CAPITAL MANAGEMENT, LLC | 33,611 | 260,000 | 0.25% | ||
| 31 | Endurant Capital Management LP | 30,984 | 240,000 | 0.23% | ||
| 32 | RTW INVESTMENTS, LP | 30,000 | 232,000 | 0.22% | ||
| 33 | CITADEL ADVISORS LLC | 22,758 | 176,000 | 0.17% | ||
| 34 | UNITED SERVICES AUTOMOBILE ASSOCIATION | 22,750 | 176,000 | 0.17% | ||
| 35 | STONERIDGE INVESTMENT PARTNERS LLC | 19,389 | 150,000 | 0.15% | ||
| 36 | BlackRock Investment Management, LLC | 15,733 | 122,000 | 0.12% | ||
| 37 | DAFNA Capital Management LLC | 15,000 | 116,000 | 0.11% | ||
| 38 | RUSSELL FRANK CO/ | 13,008 | 105,000 | 0.10% | ||
| 39 | Bank of New York Mellon Corp | 13,548 | 105,000 | 0.10% | ||
| 40 | NEW YORK STATE COMMON RETIREMENT FUND | 12,348 | 96,000 | 0.09% | ||
| 41 | Dynamic Technology Lab Private Ltd | 10,106 | 78,000 | 0.08% | ||
| 42 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 9,300 | 72,000 | 0.07% | ||
| 43 | TIAA CREF INVESTMENT MANAGEMENT LLC | 8,476 | 66,000 | 0.06% | ||
| 44 | MSI Financial Services Inc | 5,000 | 39,000 | 0.04% | ||
| 45 | TEACHERS ADVISORS, LLC | 4,804 | 37,000 | 0.04% | ||
| 46 | GLG LLC | 3,773 | 29,000 | 0.03% | ||
| 47 | BARCLAYS PLC | 4,000 | 28,000 | 0.03% | ||
| 48 | Nationwide Fund Advisors | 2,673 | 21,000 | 0.02% | ||
| 49 | STRS OHIO | 1,600 | 12,000 | 0.01% | ||
| 50 | Tower Research Capital LLC (TRC) | 1,439 | 11,000 | 0.01% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
