| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | PERCEPTIVE ADVISORS LLC | 3,448,302 | 50,000,000 | 15.08% | ||
| 2 | GREAT POINT PARTNERS LLC | 2,440,959 | 35,394,000 | 10.68% | ||
| 3 | BlackRock Finance, Inc. | 1,828,403 | 26,513,000 | 8.00% | ||
| 4 | RA CAPITAL MANAGEMENT, L.P. | 1,474,688 | 21,383,000 | 6.45% | ||
| 5 | FEDERATED HERMES, INC. | 1,176,900 | 17,065,000 | 5.15% | ||
| 6 | FMR LLC | 1,022,824 | 14,831,000 | 4.47% | ||
| 7 | KENNEDY CAPITAL MANAGEMENT LLC | 924,807 | 13,410,000 | 4.04% | ||
| 8 | VANGUARD GROUP INC | 893,523 | 12,956,000 | 3.91% | ||
| 9 | GOLDMAN SACHS GROUP INC | 867,570 | 12,580,000 | 3.79% | ||
| 10 | Invesco Ltd. | 818,537 | 11,869,000 | 3.58% | ||
| 11 | FRANKLIN RESOURCES INC | 617,625 | 8,956,000 | 2.70% | ||
| 12 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 568,500 | 8,243,000 | 2.49% | Call | |
| 13 | Lombard Odier Asset Management (USA) Corp | 469,248 | 6,804,000 | 2.05% | ||
| 14 | DIMENSIONAL FUND ADVISORS LP | 464,761 | 6,739,000 | 2.03% | ||
| 15 | STATE STREET CORP | 446,593 | 6,474,000 | 1.95% | ||
| 16 | NORTHERN TRUST CORP | 341,309 | 4,949,000 | 1.49% | ||
| 17 | ACUTA CAPITAL PARTNERS, LLC | 301,700 | 4,375,000 | 1.32% | ||
| 18 | JPMORGAN CHASE & CO | 286,299 | 4,152,000 | 1.25% | ||
| 19 | Broadfin Capital, LLC | 262,500 | 3,806,000 | 1.15% | ||
| 20 | Candriam S.C.A. | 243,000 | 3,524,000 | 1.06% | ||
| 21 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 209,600 | 3,039,000 | 0.92% | Put | |
| 22 | GEODE CAPITAL MANAGEMENT, LLC | 208,012 | 3,016,000 | 0.91% | ||
| 23 | AMERIPRISE FINANCIAL INC | 206,954 | 3,001,000 | 0.91% | ||
| 24 | DLD ASSET MANAGEMENT, LP | 201,500 | 2,916,000 | 0.88% | Put | |
| 25 | BAILARD, INC. | 192,000 | 2,784,000 | 0.84% | ||
| 26 | BAKER BROS. ADVISORS LP | 185,290 | 2,687,000 | 0.81% | ||
| 27 | FARALLON CAPITAL MANAGEMENT LLC | 175,000 | 2,538,000 | 0.77% | ||
| 28 | GAGNON SECURITIES LLC | 135,329 | 1,962,000 | 0.59% | ||
| 29 | MILLENNIUM MANAGEMENT LLC | 120,744 | 1,751,000 | 0.53% | ||
| 30 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 119,351 | 1,731,000 | 0.52% | ||
| 31 | EMORY UNIVERSITY | 118,319 | 1,716,000 | 0.52% | ||
| 32 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 108,571 | 1,574,000 | 0.47% | ||
| 33 | Bank of New York Mellon Corp | 105,926 | 1,536,000 | 0.46% | ||
| 34 | Ghost Tree Capital, LLC | 100,000 | 1,450,000 | 0.44% | ||
| 35 | ACUTA CAPITAL PARTNERS, LLC | 100,000 | 1,450,000 | 0.44% | Put | |
| 36 | Nationwide Fund Advisors | 87,611 | 1,270,000 | 0.38% | ||
| 37 | Iguana Healthcare Management, LLC | 85,000 | 1,233,000 | 0.37% | ||
| 38 | Crestline Management, LP | 72,091 | 1,045,000 | 0.32% | ||
| 39 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 68,025 | 987,000 | 0.30% | ||
| 40 | TIAA CREF INVESTMENT MANAGEMENT LLC | 66,610 | 966,000 | 0.29% | ||
| 41 | J. Goldman & Co LP | 65,000 | 943,000 | 0.28% | ||
| 42 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 57,750 | 837,000 | 0.25% | ||
| 43 | DAFNA Capital Management LLC | 55,809 | 809,000 | 0.24% | ||
| 44 | BLAIR WILLIAM & CO/IL | 54,537 | 791,000 | 0.24% | ||
| 45 | GROUP ONE TRADING LLC | 50,074 | 726,000 | 0.22% | ||
| 46 | CITADEL ADVISORS LLC | 47,200 | 684,000 | 0.21% | Call | |
| 47 | ADAMS DIVERSIFIED EQUITY FUND, INC. | 47,000 | 682,000 | 0.21% | ||
| 48 | TEACHERS ADVISORS, LLC | 44,555 | 646,000 | 0.19% | ||
| 49 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 43,959 | 637,000 | 0.19% | ||
| 50 | Allianz Asset Management GmbH | 42,940 | 629,000 | 0.19% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
