| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 2,492,361 | 33,647,000 | 10.86% | ||
| 2 | FEDERATED HERMES, INC. | 2,062,098 | 27,838,000 | 8.98% | ||
| 3 | BAKER BROS. ADVISORS LP | 1,798,365 | 24,278,000 | 7.83% | ||
| 4 | RA CAPITAL MANAGEMENT, L.P. | 1,679,500 | 22,673,000 | 7.32% | ||
| 5 | GREAT POINT PARTNERS LLC | 1,362,763 | 18,397,000 | 5.94% | ||
| 6 | Broadfin Capital, LLC | 1,107,205 | 14,947,000 | 4.82% | ||
| 7 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 1,052,500 | 14,209,000 | 4.59% | Call | |
| 8 | Invesco Ltd. | 824,615 | 11,132,000 | 3.59% | ||
| 9 | VANGUARD GROUP INC | 736,381 | 9,942,000 | 3.21% | ||
| 10 | Jefferies Group LLC | 680,100 | 9,181,000 | 2.96% | Call | |
| 11 | BlackRock Fund Advisors | 642,218 | 8,670,000 | 2.80% | ||
| 12 | FRANKLIN RESOURCES INC | 637,525 | 8,607,000 | 2.78% | ||
| 13 | BlackRock Institutional Trust Company, N.A. | 573,070 | 7,736,000 | 2.50% | ||
| 14 | MILLENNIUM MANAGEMENT LLC | 529,263 | 7,145,000 | 2.31% | ||
| 15 | GOLDMAN SACHS GROUP INC | 500,000 | 6,750,000 | 2.18% | Call | |
| 16 | KENNEDY CAPITAL MANAGEMENT LLC | 489,471 | 6,608,000 | 2.13% | ||
| 17 | Lombard Odier Asset Management (USA) Corp | 425,221 | 5,740,000 | 1.85% | ||
| 18 | Ghost Tree Capital, LLC | 370,000 | 4,995,000 | 1.61% | ||
| 19 | STATE STREET CORP | 356,462 | 4,812,000 | 1.55% | ||
| 20 | CADIAN CAPITAL MANAGEMENT, LP | 340,000 | 4,590,000 | 1.48% | ||
| 21 | OXFORD ASSET MANAGEMENT LLP | 301,391 | 4,069,000 | 1.31% | ||
| 22 | D. E. Shaw & Co., Inc. | 267,695 | 3,614,000 | 1.17% | ||
| 23 | NORTHERN TRUST CORP | 262,245 | 3,541,000 | 1.14% | ||
| 24 | Alyeska Investment Group, L.P. | 192,783 | 2,603,000 | 0.84% | ||
| 25 | Numeric Investors LLC | 175,400 | 2,368,000 | 0.76% | ||
| 26 | GOLDMAN SACHS GROUP INC | 167,075 | 2,256,000 | 0.73% | ||
| 27 | DEUTSCHE BANK AG\ | 151,063 | 2,038,000 | 0.66% | ||
| 28 | A.R.T. Advisors, LLC | 148,900 | 2,010,000 | 0.65% | ||
| 29 | GEODE CAPITAL MANAGEMENT, LLC | 135,991 | 1,835,000 | 0.59% | ||
| 30 | RENAISSANCE TECHNOLOGIES LLC | 135,287 | 1,826,000 | 0.59% | ||
| 31 | PYRRHO CAPITAL MANAGEMENT, LP | 130,400 | 1,760,000 | 0.57% | ||
| 32 | SPHERA FUNDS MANAGEMENT LTD. | 120,000 | 1,620,000 | 0.52% | ||
| 33 | Trexquant Investment LP | 117,600 | 1,587,000 | 0.51% | ||
| 34 | Candriam S.C.A. | 113,900 | 1,538,000 | 0.50% | ||
| 35 | Bank of New York Mellon Corp | 89,659 | 1,211,000 | 0.39% | ||
| 36 | J. Goldman & Co LP | 86,885 | 1,173,000 | 0.38% | ||
| 37 | BlackRock Investment Management, LLC | 84,990 | 1,147,000 | 0.37% | ||
| 38 | TIAA CREF INVESTMENT MANAGEMENT LLC | 77,211 | 1,042,000 | 0.34% | ||
| 39 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 74,639 | 1,008,000 | 0.33% | ||
| 40 | SENZAR ASSET MANAGEMENT, LLC | 71,300 | 962,550 | 0.31% | ||
| 41 | CITADEL ADVISORS LLC | 69,175 | 934,000 | 0.30% | ||
| 42 | DAFNA Capital Management LLC | 68,900 | 930,000 | 0.30% | ||
| 43 | Opus Point Partners Management, LLC | 65,700 | 887,000 | 0.29% | ||
| 44 | PEAK6 Group LLC | 65,200 | 880,000 | 0.28% | Call | |
| 45 | GSA CAPITAL PARTNERS LLP | 63,294 | 854,000 | 0.28% | ||
| 46 | AWM Investment Company, Inc. | 61,000 | 823,000 | 0.27% | ||
| 47 | WALL STREET ASSOCIATES | 50,362 | 680,000 | 0.22% | ||
| 48 | PEAK6 Group LLC | 50,000 | 675,000 | 0.22% | Put | |
| 49 | BLAIR WILLIAM & CO/IL | 48,562 | 655,000 | 0.21% | ||
| 50 | Nine Chapters Capital Management LLC | 45,100 | 609,000 | 0.20% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
