| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | RA CAPITAL MANAGEMENT, L.P. | 2,656,166 | 31,451,000 | 13.25% | ||
| 2 | GREAT POINT PARTNERS LLC | 2,440,959 | 27,900,000 | 11.76% | ||
| 3 | FMR LLC | 2,263,224 | 25,869,000 | 10.90% | ||
| 4 | FEDERATED HERMES, INC. | 1,076,300 | 12,302,000 | 5.18% | ||
| 5 | BlackRock Fund Advisors | 1,025,692 | 11,724,000 | 4.94% | ||
| 6 | BAKER BROS. ADVISORS LP | 1,000,000 | 11,430,000 | 4.82% | ||
| 7 | Broadfin Capital, LLC | 882,312 | 10,085,000 | 4.25% | ||
| 8 | VANGUARD GROUP INC | 868,990 | 9,933,000 | 4.19% | ||
| 9 | GOLDMAN SACHS GROUP INC | 853,061 | 9,750,000 | 4.11% | ||
| 10 | Invesco Ltd. | 849,787 | 9,714,000 | 4.09% | ||
| 11 | FRANKLIN RESOURCES INC | 637,525 | 7,287,000 | 3.07% | ||
| 12 | Lombard Odier Asset Management (USA) Corp | 625,252 | 7,147,000 | 3.01% | ||
| 13 | BlackRock Institutional Trust Company, N.A. | 542,283 | 6,198,000 | 2.61% | ||
| 14 | KENNEDY CAPITAL MANAGEMENT LLC | 480,452 | 5,492,000 | 2.31% | ||
| 15 | STATE STREET CORP | 418,062 | 4,780,000 | 2.01% | ||
| 16 | Ghost Tree Capital, LLC | 325,000 | 3,715,000 | 1.57% | ||
| 17 | NORTHERN TRUST CORP | 277,852 | 3,176,000 | 1.34% | ||
| 18 | NEXTHERA CAPITAL LP | 260,000 | 2,972,000 | 1.25% | ||
| 19 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 245,700 | 2,808,000 | 1.18% | Call | |
| 20 | CADIAN CAPITAL MANAGEMENT, LP | 192,500 | 2,200,000 | 0.93% | ||
| 21 | GEODE CAPITAL MANAGEMENT, LLC | 159,089 | 1,818,000 | 0.77% | ||
| 22 | MORGAN STANLEY | 154,323 | 1,764,000 | 0.74% | ||
| 23 | GAGNON SECURITIES LLC | 152,935 | 1,748,000 | 0.74% | ||
| 24 | SABBY MANAGEMENT, LLC | 150,000 | 1,715,000 | 0.72% | ||
| 25 | SENZAR ASSET MANAGEMENT, LLC | 137,900 | 1,576,197 | 0.66% | ||
| 26 | Candriam S.C.A. | 130,000 | 1,486,000 | 0.63% | ||
| 27 | BAILARD, INC. | 121,400 | 1,388,000 | 0.58% | ||
| 28 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 119,351 | 1,364,000 | 0.57% | ||
| 29 | DIMENSIONAL FUND ADVISORS LP | 107,680 | 1,231,000 | 0.52% | ||
| 30 | BlackRock Investment Management, LLC | 106,418 | 1,216,000 | 0.51% | ||
| 31 | BANK OF AMERICA CORP /DE/ | 97,435 | 1,114,000 | 0.47% | ||
| 32 | RENAISSANCE TECHNOLOGIES LLC | 93,287 | 1,066,000 | 0.45% | ||
| 33 | TIAA CREF INVESTMENT MANAGEMENT LLC | 83,377 | 953,000 | 0.40% | ||
| 34 | DAFNA Capital Management LLC | 79,538 | 909,000 | 0.38% | ||
| 35 | Bank of New York Mellon Corp | 72,295 | 826,000 | 0.35% | ||
| 36 | BLAIR WILLIAM & CO/IL | 66,400 | 759,000 | 0.32% | ||
| 37 | D. E. Shaw & Co., Inc. | 65,214 | 745,000 | 0.31% | ||
| 38 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 57,750 | 660,000 | 0.28% | ||
| 39 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 52,359 | 598,000 | 0.25% | ||
| 40 | CREDIT SUISSE AG/ | 45,752 | 523,000 | 0.22% | ||
| 41 | DEUTSCHE BANK AG\ | 44,504 | 508,000 | 0.21% | ||
| 42 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 40,225 | 460,000 | 0.19% | ||
| 43 | TEACHERS ADVISORS, LLC | 39,320 | 449,000 | 0.19% | ||
| 44 | GROUP ONE TRADING LLC | 37,246 | 426,000 | 0.18% | ||
| 45 | Allianz Asset Management GmbH | 37,586 | 402,000 | 0.17% | ||
| 46 | LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 34,337 | 392,000 | 0.17% | ||
| 47 | Healthcare Value Capital, LLC | 31,850 | 364,000 | 0.15% | ||
| 48 | RHUMBLINE ADVISERS | 31,135 | 356,000 | 0.15% | ||
| 49 | Palo Alto Investors LP | 29,500 | 337,000 | 0.14% | ||
| 50 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 27,944 | 319,000 | 0.13% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
