| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 2,821,843 | 26,074,000 | 12.75% | ||
| 2 | RA CAPITAL MANAGEMENT, L.P. | 2,451,237 | 22,649,000 | 11.08% | ||
| 3 | FEDERATED HERMES, INC. | 2,191,106 | 20,246,000 | 9.90% | ||
| 4 | GREAT POINT PARTNERS LLC | 2,085,959 | 19,274,000 | 9.42% | ||
| 5 | BAKER BROS. ADVISORS LP | 1,000,000 | 9,240,000 | 4.52% | ||
| 6 | BlackRock Fund Advisors | 957,906 | 8,851,000 | 4.33% | ||
| 7 | Broadfin Capital, LLC | 882,312 | 8,153,000 | 3.99% | ||
| 8 | Invesco Ltd. | 879,829 | 8,130,000 | 3.98% | ||
| 9 | GOLDMAN SACHS GROUP INC | 864,747 | 7,990,000 | 3.91% | ||
| 10 | VANGUARD GROUP INC | 805,047 | 7,439,000 | 3.64% | ||
| 11 | FRANKLIN RESOURCES INC | 637,525 | 5,891,000 | 2.88% | ||
| 12 | Lombard Odier Asset Management (USA) Corp | 633,502 | 5,854,000 | 2.86% | ||
| 13 | BlackRock Institutional Trust Company, N.A. | 576,020 | 5,322,000 | 2.60% | ||
| 14 | KENNEDY CAPITAL MANAGEMENT LLC | 483,872 | 4,471,000 | 2.19% | ||
| 15 | STATE STREET CORP | 383,552 | 3,546,000 | 1.73% | ||
| 16 | NORTHERN TRUST CORP | 297,546 | 2,750,000 | 1.34% | ||
| 17 | SENZAR ASSET MANAGEMENT, LLC | 268,600 | 2,481,864 | 1.21% | ||
| 18 | SABBY MANAGEMENT, LLC | 254,424 | 2,351,000 | 1.15% | ||
| 19 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 250,400 | 2,314,000 | 1.13% | Call | |
| 20 | Opaleye Management Inc. | 240,000 | 2,218,000 | 1.08% | ||
| 21 | GOLDMAN SACHS GROUP INC | 240,000 | 2,218,000 | 1.08% | Call | |
| 22 | Sculptor Capital LP | 198,845 | 1,837,000 | 0.90% | ||
| 23 | BOXER CAPITAL, LLC | 168,000 | 1,552,000 | 0.76% | ||
| 24 | LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 155,705 | 1,439,000 | 0.70% | ||
| 25 | GEODE CAPITAL MANAGEMENT, LLC | 153,464 | 1,418,000 | 0.69% | ||
| 26 | CADIAN CAPITAL MANAGEMENT, LP | 147,500 | 1,363,000 | 0.67% | ||
| 27 | OXFORD ASSET MANAGEMENT LLP | 116,093 | 1,073,000 | 0.52% | ||
| 28 | D. E. Shaw & Co., Inc. | 109,121 | 1,008,000 | 0.49% | ||
| 29 | Candriam S.C.A. | 105,000 | 965,000 | 0.47% | ||
| 30 | BlackRock Investment Management, LLC | 85,869 | 793,000 | 0.39% | ||
| 31 | Bank of New York Mellon Corp | 84,759 | 783,000 | 0.38% | ||
| 32 | MILLENNIUM MANAGEMENT LLC | 83,584 | 772,000 | 0.38% | ||
| 33 | DAFNA Capital Management LLC | 79,400 | 734,000 | 0.36% | ||
| 34 | CORNERSTONE CAPITAL MANAGEMENT HOLDINGS LLC. | 76,587 | 708,000 | 0.35% | ||
| 35 | RENAISSANCE TECHNOLOGIES LLC | 74,087 | 685,000 | 0.33% | ||
| 36 | TIAA CREF INVESTMENT MANAGEMENT LLC | 73,405 | 678,000 | 0.33% | ||
| 37 | Opus Point Partners Management, LLC | 68,130 | 630,000 | 0.31% | ||
| 38 | PURA VIDA INVESTMENTS, LLC | 58,750 | 543,000 | 0.27% | ||
| 39 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 57,750 | 534,000 | 0.26% | ||
| 40 | BLAIR WILLIAM & CO/IL | 57,650 | 532,000 | 0.26% | ||
| 41 | TFS CAPITAL LLC | 57,442 | 531,000 | 0.26% | ||
| 42 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 52,259 | 483,000 | 0.24% | ||
| 43 | J. Goldman & Co LP | 52,000 | 480,000 | 0.23% | ||
| 44 | GROUP ONE TRADING LLC | 43,946 | 406,000 | 0.20% | ||
| 45 | DEUTSCHE BANK AG\ | 41,754 | 385,000 | 0.19% | ||
| 46 | Allianz Asset Management GmbH | 41,601 | 384,000 | 0.19% | ||
| 47 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 40,225 | 372,000 | 0.18% | ||
| 48 | TEACHERS ADVISORS, LLC | 36,094 | 334,000 | 0.16% | ||
| 49 | DIMENSIONAL FUND ADVISORS LP | 34,765 | 321,000 | 0.16% | ||
| 50 | Healthcare Value Capital, LLC | 31,850 | 294,000 | 0.14% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
