| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | RA CAPITAL MANAGEMENT, L.P. | 2,451,237 | 29,783,000 | 11.29% | ||
| 2 | GREAT POINT PARTNERS LLC | 2,440,959 | 29,658,000 | 11.24% | ||
| 3 | FMR LLC | 1,774,324 | 21,558,000 | 8.17% | ||
| 4 | FEDERATED HERMES, INC. | 1,484,500 | 18,037,000 | 6.84% | ||
| 5 | BlackRock Fund Advisors | 1,163,742 | 14,139,000 | 5.36% | ||
| 6 | VANGUARD GROUP INC | 904,331 | 10,988,000 | 4.16% | ||
| 7 | GOLDMAN SACHS GROUP INC | 873,583 | 10,614,000 | 4.02% | ||
| 8 | Invesco Ltd. | 853,219 | 10,366,000 | 3.93% | ||
| 9 | BAKER BROS. ADVISORS LP | 838,809 | 10,192,000 | 3.86% | ||
| 10 | Broadfin Capital, LLC | 766,412 | 9,312,000 | 3.53% | ||
| 11 | PERCEPTIVE ADVISORS LLC | 752,999 | 9,149,000 | 3.47% | ||
| 12 | KENNEDY CAPITAL MANAGEMENT LLC | 726,794 | 8,831,000 | 3.35% | ||
| 13 | FRANKLIN RESOURCES INC | 637,525 | 7,746,000 | 2.94% | ||
| 14 | Lombard Odier Asset Management (USA) Corp | 600,000 | 7,290,000 | 2.76% | ||
| 15 | BlackRock Institutional Trust Company, N.A. | 563,602 | 6,848,000 | 2.60% | ||
| 16 | STATE STREET CORP | 417,985 | 5,081,000 | 1.93% | ||
| 17 | NORTHERN TRUST CORP | 305,294 | 3,709,000 | 1.41% | ||
| 18 | Ghost Tree Capital, LLC | 225,000 | 2,734,000 | 1.04% | ||
| 19 | DIMENSIONAL FUND ADVISORS LP | 216,814 | 2,634,000 | 1.00% | ||
| 20 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 211,100 | 2,565,000 | 0.97% | Call | |
| 21 | CADIAN CAPITAL MANAGEMENT, LP | 182,500 | 2,217,000 | 0.84% | ||
| 22 | EMORY UNIVERSITY | 177,841 | 2,161,000 | 0.82% | ||
| 23 | GEODE CAPITAL MANAGEMENT, LLC | 174,386 | 2,118,000 | 0.80% | ||
| 24 | AMERIPRISE FINANCIAL INC | 159,582 | 1,939,000 | 0.73% | ||
| 25 | SENZAR ASSET MANAGEMENT, LLC | 158,100 | 1,921,000 | 0.73% | ||
| 26 | BAILARD, INC. | 152,000 | 1,847,000 | 0.70% | ||
| 27 | NEXTHERA CAPITAL LP | 150,000 | 1,823,000 | 0.69% | ||
| 28 | Candriam S.C.A. | 150,000 | 1,822,000 | 0.69% | ||
| 29 | GAGNON SECURITIES LLC | 140,690 | 1,709,000 | 0.65% | ||
| 30 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 119,351 | 1,450,000 | 0.55% | ||
| 31 | BANK OF AMERICA CORP /DE/ | 118,948 | 1,445,000 | 0.55% | ||
| 32 | CITY FINANCIAL INVESTMENT CO LTD | 114,654 | 1,393,000 | 0.53% | ||
| 33 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 109,445 | 1,330,000 | 0.50% | ||
| 34 | BlackRock Investment Management, LLC | 105,531 | 1,282,000 | 0.49% | ||
| 35 | DLD ASSET MANAGEMENT, LP | 104,400 | 1,271,000 | 0.48% | Call | |
| 36 | Bank of New York Mellon Corp | 98,876 | 1,201,000 | 0.46% | ||
| 37 | WELLS FARGO & COMPANY/MN | 95,637 | 1,162,000 | 0.44% | ||
| 38 | DAFNA Capital Management LLC | 74,538 | 906,000 | 0.34% | ||
| 39 | TIAA CREF INVESTMENT MANAGEMENT LLC | 73,149 | 889,000 | 0.34% | ||
| 40 | MORGAN STANLEY | 72,840 | 885,000 | 0.34% | ||
| 41 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 68,025 | 827,000 | 0.31% | ||
| 42 | MILLENNIUM MANAGEMENT LLC | 63,711 | 774,000 | 0.29% | ||
| 43 | GROUP ONE TRADING LLC | 57,894 | 703,000 | 0.27% | ||
| 44 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 57,750 | 702,000 | 0.27% | ||
| 45 | D. E. Shaw & Co., Inc. | 54,523 | 662,000 | 0.25% | ||
| 46 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 51,059 | 620,000 | 0.24% | ||
| 47 | BLAIR WILLIAM & CO/IL | 50,937 | 619,000 | 0.23% | ||
| 48 | TEACHERS ADVISORS, LLC | 39,320 | 478,000 | 0.18% | ||
| 49 | Allianz Asset Management GmbH | 37,586 | 457,000 | 0.17% | ||
| 50 | LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 34,337 | 417,000 | 0.16% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
