| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 2,921,071 | 43,057,000 | 13.20% | ||
| 2 | RA CAPITAL MANAGEMENT, L.P. | 2,253,237 | 33,213,000 | 10.19% | ||
| 3 | FEDERATED HERMES, INC. | 2,191,106 | 32,297,000 | 9.91% | ||
| 4 | GREAT POINT PARTNERS LLC | 1,414,927 | 20,856,000 | 6.40% | ||
| 5 | Broadfin Capital, LLC | 1,087,112 | 16,024,000 | 4.91% | ||
| 6 | BAKER BROS. ADVISORS LP | 1,000,000 | 14,740,000 | 4.52% | ||
| 7 | BlackRock Fund Advisors | 955,634 | 14,086,000 | 4.32% | ||
| 8 | Invesco Ltd. | 828,952 | 12,218,000 | 3.75% | ||
| 9 | VANGUARD GROUP INC | 778,961 | 11,482,000 | 3.52% | ||
| 10 | FRANKLIN RESOURCES INC | 637,525 | 9,397,000 | 2.88% | ||
| 11 | Lombard Odier Asset Management (USA) Corp | 600,929 | 8,858,000 | 2.72% | ||
| 12 | BlackRock Institutional Trust Company, N.A. | 558,355 | 8,230,000 | 2.52% | ||
| 13 | GOLDMAN SACHS GROUP INC | 500,000 | 7,370,000 | 2.26% | Call | |
| 14 | KENNEDY CAPITAL MANAGEMENT LLC | 488,558 | 7,201,000 | 2.21% | ||
| 15 | SENZAR ASSET MANAGEMENT, LLC | 377,600 | 5,565,824 | 1.71% | ||
| 16 | STATE STREET CORP | 368,106 | 5,423,000 | 1.66% | ||
| 17 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 349,100 | 5,146,000 | 1.58% | Call | |
| 18 | CADIAN CAPITAL MANAGEMENT, LP | 340,000 | 5,012,000 | 1.54% | ||
| 19 | TFS CAPITAL LLC | 327,483 | 4,827,000 | 1.48% | ||
| 20 | D. E. Shaw & Co., Inc. | 305,201 | 4,499,000 | 1.38% | ||
| 21 | NORTHERN TRUST CORP | 294,329 | 4,338,000 | 1.33% | ||
| 22 | MILLENNIUM MANAGEMENT LLC | 237,461 | 3,500,000 | 1.07% | ||
| 23 | BOXER CAPITAL, LLC | 225,000 | 3,317,000 | 1.02% | ||
| 24 | Iguana Healthcare Management, LLC | 150,000 | 2,211,000 | 0.68% | ||
| 25 | J. Goldman & Co LP | 149,500 | 2,204,000 | 0.68% | ||
| 26 | PYRRHO CAPITAL MANAGEMENT, LP | 148,260 | 2,185,000 | 0.67% | ||
| 27 | GEODE CAPITAL MANAGEMENT, LLC | 137,371 | 2,024,000 | 0.62% | ||
| 28 | RENAISSANCE TECHNOLOGIES LLC | 136,887 | 2,018,000 | 0.62% | ||
| 29 | GOLDMAN SACHS GROUP INC | 127,551 | 1,880,000 | 0.58% | ||
| 30 | Candriam S.C.A. | 113,900 | 1,679,000 | 0.51% | ||
| 31 | Opus Point Partners Management, LLC | 95,700 | 1,411,000 | 0.43% | ||
| 32 | Alyeska Investment Group, L.P. | 95,168 | 1,403,000 | 0.43% | ||
| 33 | Bank of New York Mellon Corp | 87,697 | 1,293,000 | 0.40% | ||
| 34 | BlackRock Investment Management, LLC | 85,903 | 1,266,000 | 0.39% | ||
| 35 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 85,250 | 1,257,000 | 0.39% | ||
| 36 | CORNERSTONE CAPITAL MANAGEMENT HOLDINGS LLC. | 78,456 | 1,156,000 | 0.35% | ||
| 37 | OXFORD ASSET MANAGEMENT LLP | 76,638 | 1,152,000 | 0.35% | ||
| 38 | TIAA CREF INVESTMENT MANAGEMENT LLC | 77,211 | 1,138,000 | 0.35% | ||
| 39 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 74,639 | 1,100,000 | 0.34% | ||
| 40 | STIFEL FINANCIAL CORP | 7,420 | 1,038,000 | 0.32% | ||
| 41 | DAFNA Capital Management LLC | 69,400 | 1,023,000 | 0.31% | ||
| 42 | Trexquant Investment LP | 66,331 | 978,000 | 0.30% | ||
| 43 | PURA VIDA INVESTMENTS, LLC | 58,750 | 866,000 | 0.27% | ||
| 44 | CREDIT SUISSE AG/ | 54,405 | 802,000 | 0.25% | ||
| 45 | PEAK6 Group LLC | 53,600 | 790,000 | 0.24% | Call | |
| 46 | PEAK6 Group LLC | 50,000 | 737,000 | 0.23% | Put | |
| 47 | WALL STREET ASSOCIATES | 47,782 | 704,000 | 0.22% | ||
| 48 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 45,711 | 674,000 | 0.21% | ||
| 49 | BLAIR WILLIAM & CO/IL | 41,900 | 617,000 | 0.19% | ||
| 50 | Allianz Asset Management GmbH | 41,175 | 599,000 | 0.18% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
