| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | EVENTIDE ASSET MANAGEMENT, LLC | 2,010,278 | 38,718,000 | 12.63% | ||
| 2 | FRAZIER MANAGEMENT LLC | 1,887,332 | 36,350,000 | 11.85% | ||
| 3 | Rock Springs Capital Management LP | 1,545,000 | 29,757,000 | 9.70% | ||
| 4 | HealthCor Management, L.P. | 1,400,000 | 26,964,000 | 8.79% | ||
| 5 | TPG Group Holdings (SBS) Advisors, Inc. | 1,389,863 | 26,769,000 | 8.73% | ||
| 6 | FRANKLIN RESOURCES INC | 907,034 | 17,469,000 | 5.70% | ||
| 7 | FMR LLC | 762,073 | 14,678,000 | 4.79% | ||
| 8 | SECTORAL ASSET MANAGEMENT INC | 705,845 | 13,595,000 | 4.43% | ||
| 9 | BlackRock Fund Advisors | 694,055 | 13,367,000 | 4.36% | ||
| 10 | VANGUARD GROUP INC | 522,588 | 10,065,000 | 3.28% | ||
| 11 | MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 508,995 | 9,803,000 | 3.20% | ||
| 12 | CADIAN CAPITAL MANAGEMENT, LP | 480,141 | 9,248,000 | 3.02% | ||
| 13 | Cormorant Asset Management, LP | 455,515 | 8,773,000 | 2.86% | ||
| 14 | PFM Health Sciences, LP | 402,446 | 7,751,000 | 2.53% | ||
| 15 | HIGHLAND CAPITAL MANAGEMENT LP | 326,500 | 6,289,000 | 2.05% | ||
| 16 | BlackRock Institutional Trust Company, N.A. | 261,332 | 5,033,000 | 1.64% | ||
| 17 | STATE STREET CORP | 197,932 | 3,815,000 | 1.24% | ||
| 18 | NORTHERN TRUST CORP | 176,547 | 3,400,000 | 1.11% | ||
| 19 | LPL Financial LLC | 119,071 | 2,396,000 | 0.78% | ||
| 20 | DEUTSCHE BANK AG\ | 123,628 | 2,379,000 | 0.78% | ||
| 21 | GEODE CAPITAL MANAGEMENT, LLC | 105,569 | 2,033,000 | 0.66% | ||
| 22 | J. Goldman & Co LP | 78,000 | 1,502,000 | 0.49% | ||
| 23 | RAYMOND JAMES & ASSOCIATES | 71,915 | 1,385,000 | 0.45% | ||
| 24 | NBW CAPITAL LLC | 61,759 | 1,189,000 | 0.39% | ||
| 25 | BUCKINGHAM CAPITAL MANAGEMENT INC | 53,300 | 1,027,000 | 0.33% | ||
| 26 | Bank of New York Mellon Corp | 51,900 | 999,000 | 0.33% | ||
| 27 | BlackRock Investment Management, LLC | 51,471 | 991,000 | 0.32% | ||
| 28 | TOCQUEVILLE ASSET MANAGEMENT L.P. | 50,900 | 980,000 | 0.32% | ||
| 29 | BARCLAYS PLC | 45,000 | 867,000 | 0.28% | Put | |
| 30 | Pier Capital, LLC | 44,700 | 861,000 | 0.28% | ||
| 31 | TIAA CREF INVESTMENT MANAGEMENT LLC | 42,761 | 824,000 | 0.27% | ||
| 32 | TFS CAPITAL LLC | 33,911 | 653,000 | 0.21% | ||
| 33 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 28,695 | 553,000 | 0.18% | ||
| 34 | PDT Partners, LLC | 23,800 | 458,000 | 0.15% | ||
| 35 | TEACHERS ADVISORS, LLC | 21,545 | 415,000 | 0.14% | ||
| 36 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 21,336 | 411,000 | 0.13% | ||
| 37 | Swiss National Bank | 17,900 | 345,000 | 0.11% | ||
| 38 | MYCIO WEALTH PARTNERS, LLC | 17,000 | 327,000 | 0.11% | ||
| 39 | M&T BANK CORP | 17,000 | 327,000 | 0.11% | ||
| 40 | ProShare Advisors LLC | 16,175 | 312,000 | 0.10% | ||
| 41 | ROYAL BANK OF CANADA | 15,350 | 296,000 | 0.10% | ||
| 42 | NEW YORK STATE COMMON RETIREMENT FUND | 13,800 | 266,000 | 0.09% | ||
| 43 | RHUMBLINE ADVISERS | 12,250 | 236,000 | 0.08% | ||
| 44 | Sterling Capital Management LLC | 12,000 | 231,000 | 0.08% | ||
| 45 | CREDIT SUISSE AG/ | 11,847 | 228,000 | 0.07% | ||
| 46 | GOLDMAN SACHS GROUP INC | 11,546 | 222,000 | 0.07% | ||
| 47 | BARCLAYS PLC | 11,308 | 218,000 | 0.07% | ||
| 48 | ALLIANCEBERNSTEIN L.P. | 11,300 | 218,000 | 0.07% | ||
| 49 | WELLS FARGO & COMPANY/MN | 8,865 | 171,000 | 0.06% | ||
| 50 | Nationwide Fund Advisors | 8,665 | 167,000 | 0.05% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
