| 1 |
RA CAPITAL MANAGEMENT, L.P. |
1,553,175 |
34,341,000 |
15.16% |
|
|
| 2 |
TPG Group Holdings (SBS) Advisors, Inc. |
1,325,263 |
29,302,000 |
12.94% |
|
|
| 3 |
ADAGE CAPITAL PARTNERS GP, L.L.C. |
1,007,012 |
22,265,000 |
9.83% |
|
|
| 4 |
Rock Springs Capital Management LP |
994,400 |
21,986,000 |
9.71% |
|
|
| 5 |
EVENTIDE ASSET MANAGEMENT, LLC |
975,418 |
21,566,000 |
9.52% |
|
|
| 6 |
HealthCor Management, L.P. |
950,000 |
21,005,000 |
9.27% |
|
|
| 7 |
EcoR1 Capital, LLC |
465,118 |
10,284,000 |
4.54% |
|
|
| 8 |
Cormorant Asset Management, LP |
450,000 |
9,950,000 |
4.39% |
|
|
| 9 |
FMR LLC |
450,000 |
9,950,000 |
4.39% |
|
|
| 10 |
MASSACHUSETTS FINANCIAL SERVICES CO /MA/ |
359,966 |
7,959,000 |
3.51% |
|
|
| 11 |
FRANKLIN RESOURCES INC |
335,300 |
7,413,000 |
3.27% |
|
|
| 12 |
VANGUARD GROUP INC |
186,892 |
4,132,000 |
1.82% |
|
|
| 13 |
WESTFIELD CAPITAL MANAGEMENT CO LP |
184,461 |
4,078,000 |
1.80% |
|
|
| 14 |
BlackRock Fund Advisors |
174,555 |
3,859,000 |
1.70% |
|
|
| 15 |
BlackRock Institutional Trust Company, N.A. |
138,481 |
3,062,000 |
1.35% |
|
|
| 16 |
STATE STREET CORP |
71,430 |
1,577,000 |
0.70% |
|
|
| 17 |
NORTHERN TRUST CORP |
67,662 |
1,496,000 |
0.66% |
|
|
| 18 |
NBW CAPITAL LLC |
67,017 |
1,482,000 |
0.65% |
|
|
| 19 |
Birchview Capital, LP |
58,768 |
1,299,000 |
0.57% |
|
|
| 20 |
TOCQUEVILLE ASSET MANAGEMENT L.P. |
50,000 |
1,106,000 |
0.49% |
|
|
| 21 |
Informed Momentum Co LLC |
43,816 |
969,000 |
0.43% |
|
|
| 22 |
GEODE CAPITAL MANAGEMENT, LLC |
37,987 |
839,000 |
0.37% |
|
|
| 23 |
BENNETT LAWRENCE MANAGEMENT L L C/NY |
36,275 |
802,000 |
0.35% |
|
|
| 24 |
RUSSELL FRANK CO/ |
34,922 |
772,000 |
0.34% |
|
|
| 25 |
RENAISSANCE TECHNOLOGIES LLC |
31,800 |
703,000 |
0.31% |
|
|
| 26 |
ELLINGTON MANAGEMENT GROUP LLC |
27,300 |
604,000 |
0.27% |
|
|
| 27 |
Bank of New York Mellon Corp |
26,892 |
594,000 |
0.26% |
|
|
| 28 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
25,762 |
570,000 |
0.25% |
|
|
| 29 |
BlackRock Investment Management, LLC |
25,085 |
555,000 |
0.25% |
|
|
| 30 |
DEUTSCHE BANK AG\ |
20,269 |
447,000 |
0.20% |
|
|
| 31 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
12,182 |
269,000 |
0.12% |
|
|
| 32 |
BANK OF AMERICA CORP /DE/ |
11,058 |
244,000 |
0.11% |
|
|
| 33 |
TEACHERS ADVISORS, LLC |
9,649 |
213,000 |
0.09% |
|
|
| 34 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
9,087 |
201,000 |
0.09% |
|
|
| 35 |
NEW YORK STATE COMMON RETIREMENT FUND |
6,100 |
135,000 |
0.06% |
|
|
| 36 |
MYCIO WEALTH PARTNERS, LLC |
5,000 |
111,000 |
0.05% |
|
|
| 37 |
Nationwide Fund Advisors |
4,269 |
94,000 |
0.04% |
|
|
| 38 |
AMERICAN INTERNATIONAL GROUP, INC. |
3,913 |
87,000 |
0.04% |
|
|
| 39 |
BLACKROCK ADVISORS LLC |
3,407 |
75,000 |
0.03% |
|
|
| 40 |
STRS OHIO |
2,100 |
46,000 |
0.02% |
|
|
| 41 |
BNP PARIBAS FINANCIAL MARKETS |
1,378 |
30,468 |
0.01% |
|
|
| 42 |
PIPER SANDLER & CO. |
800 |
18,000 |
0.01% |
|
|
| 43 |
UBS Group AG |
500 |
11,000 |
0.00% |
|
|
| 44 |
ROYAL BANK OF CANADA |
299 |
7,000 |
0.00% |
|
|
| 45 |
Gemmer Asset Management LLC |
100 |
2,000 |
0.00% |
|
|
| 46 |
WELLS FARGO & COMPANY/MN |
33 |
1,000 |
0.00% |
|
|
| 47 |
BARCLAYS PLC |
35 |
1,000 |
0.00% |
|
|
| 48 |
TAYLOR WEALTH MANAGEMENT PARTNERS |
61 |
1,000 |
0.00% |
|
|
| 49 |
CITIGROUP INC |
1 |
0 |
0.00% |
|
|
