| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FRAZIER MANAGEMENT LLC | 1,877,332 | 51,627,000 | 15.81% | ||
| 2 | TPG Group Holdings (SBS) Advisors, Inc. | 1,325,263 | 36,445,000 | 11.16% | ||
| 3 | EVENTIDE ASSET MANAGEMENT, LLC | 1,066,400 | 29,326,000 | 8.98% | ||
| 4 | HealthCor Management, L.P. | 1,025,000 | 28,188,000 | 8.63% | ||
| 5 | Rock Springs Capital Management LP | 1,005,487 | 27,651,000 | 8.47% | ||
| 6 | RA CAPITAL MANAGEMENT, L.P. | 857,683 | 23,586,000 | 7.22% | ||
| 7 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 840,104 | 23,103,000 | 7.07% | ||
| 8 | FMR LLC | 580,000 | 15,950,000 | 4.88% | ||
| 9 | EcoR1 Capital, LLC | 465,118 | 12,791,000 | 3.92% | ||
| 10 | Cormorant Asset Management, LP | 450,000 | 12,375,000 | 3.79% | ||
| 11 | BlackRock Fund Advisors | 418,194 | 11,500,000 | 3.52% | ||
| 12 | MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 357,584 | 9,833,000 | 3.01% | ||
| 13 | FRANKLIN RESOURCES INC | 324,300 | 8,919,000 | 2.73% | ||
| 14 | VANGUARD GROUP INC | 248,321 | 6,828,000 | 2.09% | ||
| 15 | BlackRock Institutional Trust Company, N.A. | 140,228 | 3,856,000 | 1.18% | ||
| 16 | NORTHERN TRUST CORP | 84,135 | 2,313,000 | 0.71% | ||
| 17 | STATE STREET CORP | 75,865 | 2,090,000 | 0.64% | ||
| 18 | BANK OF AMERICA CORP /DE/ | 66,852 | 1,838,000 | 0.56% | ||
| 19 | NBW CAPITAL LLC | 63,486 | 1,746,000 | 0.53% | ||
| 20 | Birchview Capital, LP | 58,768 | 1,616,000 | 0.49% | ||
| 21 | TOCQUEVILLE ASSET MANAGEMENT L.P. | 55,800 | 1,535,000 | 0.47% | ||
| 22 | LPL Financial LLC | 52,600 | 1,260,000 | 0.39% | ||
| 23 | GEODE CAPITAL MANAGEMENT, LLC | 45,120 | 1,240,000 | 0.38% | ||
| 24 | Informed Momentum Co LLC | 42,850 | 1,178,000 | 0.36% | ||
| 25 | GOLDMAN SACHS GROUP INC | 40,834 | 1,123,000 | 0.34% | ||
| 26 | RUSSELL FRANK CO/ | 34,922 | 1,004,000 | 0.31% | ||
| 27 | BENNETT LAWRENCE MANAGEMENT L L C/NY | 35,920 | 987,000 | 0.30% | ||
| 28 | TIAA CREF INVESTMENT MANAGEMENT LLC | 28,260 | 777,000 | 0.24% | ||
| 29 | Bank of New York Mellon Corp | 26,892 | 739,000 | 0.23% | ||
| 30 | MORGAN STANLEY | 25,505 | 701,000 | 0.21% | ||
| 31 | BlackRock Investment Management, LLC | 24,498 | 674,000 | 0.21% | ||
| 32 | ProShare Advisors LLC | 17,605 | 484,000 | 0.15% | ||
| 33 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 12,382 | 341,000 | 0.10% | ||
| 34 | RENAISSANCE TECHNOLOGIES LLC | 11,933 | 328,000 | 0.10% | ||
| 35 | MYCIO WEALTH PARTNERS, LLC | 11,000 | 303,000 | 0.09% | ||
| 36 | D. E. Shaw & Co., Inc. | 9,804 | 270,000 | 0.08% | ||
| 37 | TEACHERS ADVISORS, LLC | 9,649 | 265,000 | 0.08% | ||
| 38 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 8,736 | 241,000 | 0.07% | ||
| 39 | PANAGORA ASSET MANAGEMENT INC | 8,742 | 240,000 | 0.07% | ||
| 40 | TWO SIGMA INVESTMENTS, LP | 8,500 | 234,000 | 0.07% | ||
| 41 | NEW YORK STATE COMMON RETIREMENT FUND | 6,100 | 168,000 | 0.05% | ||
| 42 | WELLS FARGO & COMPANY/MN | 5,701 | 157,000 | 0.05% | ||
| 43 | CITIGROUP INC | 4,841 | 133,000 | 0.04% | ||
| 44 | Nationwide Fund Advisors | 4,269 | 117,000 | 0.04% | ||
| 45 | DEUTSCHE BANK AG\ | 4,285 | 116,000 | 0.04% | ||
| 46 | AMERICAN INTERNATIONAL GROUP, INC. | 3,906 | 107,000 | 0.03% | ||
| 47 | BLACKROCK ADVISORS LLC | 2,324 | 64,000 | 0.02% | ||
| 48 | UBS Group AG | 2,292 | 63,000 | 0.02% | ||
| 49 | STRS OHIO | 2,100 | 57,000 | 0.02% | ||
| 50 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 1,283 | 35,000 | 0.01% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
