| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | EVENTIDE ASSET MANAGEMENT, LLC | 1,950,276 | 23,111,000 | 13.33% | ||
| 2 | FRAZIER MANAGEMENT LLC | 1,887,332 | 22,365,000 | 12.90% | ||
| 3 | TPG Group Holdings (SBS) Advisors, Inc. | 1,389,863 | 16,470,000 | 9.50% | ||
| 4 | HealthCor Management, L.P. | 1,325,000 | 15,701,000 | 9.06% | ||
| 5 | Rock Springs Capital Management LP | 1,215,000 | 14,398,000 | 8.31% | ||
| 6 | FRANKLIN RESOURCES INC | 903,602 | 10,708,000 | 6.18% | ||
| 7 | FMR LLC | 802,373 | 9,508,000 | 5.48% | ||
| 8 | BlackRock Fund Advisors | 650,474 | 7,708,000 | 4.45% | ||
| 9 | MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 500,309 | 5,929,000 | 3.42% | ||
| 10 | VANGUARD GROUP INC | 485,809 | 5,757,000 | 3.32% | ||
| 11 | Cormorant Asset Management, LP | 455,515 | 5,398,000 | 3.11% | ||
| 12 | SECTORAL ASSET MANAGEMENT INC | 294,400 | 3,489,000 | 2.01% | ||
| 13 | EcoR1 Capital, LLC | 281,776 | 3,339,000 | 1.93% | ||
| 14 | Bank of New York Mellon Corp | 272,981 | 3,235,000 | 1.87% | ||
| 15 | BlackRock Institutional Trust Company, N.A. | 261,332 | 3,097,000 | 1.79% | ||
| 16 | STATE STREET CORP | 176,997 | 2,097,000 | 1.21% | ||
| 17 | NORTHERN TRUST CORP | 171,468 | 2,032,000 | 1.17% | ||
| 18 | HIGHLAND CAPITAL MANAGEMENT LP | 161,625 | 1,916,000 | 1.11% | ||
| 19 | AGF INVESTMENTS INC. | 111,509 | 1,321,000 | 0.76% | ||
| 20 | SABBY MANAGEMENT, LLC | 101,410 | 1,202,000 | 0.69% | ||
| 21 | LPL Financial LLC | 95,898 | 1,198,000 | 0.69% | ||
| 22 | J. Goldman & Co LP | 99,000 | 1,173,000 | 0.68% | ||
| 23 | TAMARACK ADVISERS, LP | 94,908 | 1,125,000 | 0.65% | ||
| 24 | GEODE CAPITAL MANAGEMENT, LLC | 85,421 | 1,012,000 | 0.58% | ||
| 25 | RAYMOND JAMES & ASSOCIATES | 68,695 | 814,000 | 0.47% | ||
| 26 | DEUTSCHE BANK AG\ | 67,697 | 801,000 | 0.46% | ||
| 27 | NBW CAPITAL LLC | 62,106 | 736,000 | 0.42% | ||
| 28 | TOCQUEVILLE ASSET MANAGEMENT L.P. | 51,900 | 615,000 | 0.35% | ||
| 29 | BlackRock Investment Management, LLC | 51,546 | 611,000 | 0.35% | ||
| 30 | TFS CAPITAL LLC | 48,536 | 575,000 | 0.33% | ||
| 31 | GOLDMAN SACHS GROUP INC | 44,088 | 522,000 | 0.30% | ||
| 32 | TIAA CREF INVESTMENT MANAGEMENT LLC | 42,761 | 507,000 | 0.29% | ||
| 33 | MORGAN STANLEY | 41,329 | 490,000 | 0.28% | ||
| 34 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 28,395 | 336,000 | 0.19% | ||
| 35 | CREDIT SUISSE AG/ | 27,490 | 326,000 | 0.19% | ||
| 36 | PDT Partners, LLC | 23,800 | 282,000 | 0.16% | ||
| 37 | TEACHERS ADVISORS, LLC | 21,545 | 255,000 | 0.15% | ||
| 38 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 21,336 | 253,000 | 0.15% | ||
| 39 | Neuberger Berman Group LLC | 20,000 | 237,000 | 0.14% | ||
| 40 | ProShare Advisors LLC | 19,174 | 227,000 | 0.13% | ||
| 41 | Swiss National Bank | 17,900 | 212,000 | 0.12% | ||
| 42 | MYCIO WEALTH PARTNERS, LLC | 17,000 | 201,000 | 0.12% | ||
| 43 | HIGHBRIDGE CAPITAL MANAGEMENT LLC | 13,951 | 166,000 | 0.10% | ||
| 44 | NEW YORK STATE COMMON RETIREMENT FUND | 13,800 | 164,000 | 0.09% | ||
| 45 | CLOUGH CAPITAL PARTNERS L P | 13,700 | 162,000 | 0.09% | ||
| 46 | M&T BANK CORP | 13,379 | 159,000 | 0.09% | ||
| 47 | A.R.T. Advisors, LLC | 12,500 | 148,000 | 0.09% | ||
| 48 | RHUMBLINE ADVISERS | 12,050 | 143,000 | 0.08% | ||
| 49 | ROYAL BANK OF CANADA | 11,600 | 137,000 | 0.08% | ||
| 50 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 10,368 | 123,000 | 0.07% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
