| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FRAZIER MANAGEMENT LLC | 1,887,332 | 34,255,000 | 12.70% | ||
| 2 | EVENTIDE ASSET MANAGEMENT, LLC | 1,865,278 | 33,855,000 | 12.55% | ||
| 3 | TPG Group Holdings (SBS) Advisors, Inc. | 1,325,263 | 24,054,000 | 8.92% | ||
| 4 | HealthCor Management, L.P. | 1,225,000 | 22,234,000 | 8.24% | ||
| 5 | Rock Springs Capital Management LP | 1,145,000 | 20,782,000 | 7.70% | ||
| 6 | FRANKLIN RESOURCES INC | 829,599 | 15,057,000 | 5.58% | ||
| 7 | FMR LLC | 560,300 | 10,169,000 | 3.77% | ||
| 8 | BlackRock Fund Advisors | 503,013 | 9,130,000 | 3.38% | ||
| 9 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 490,104 | 8,895,000 | 3.30% | ||
| 10 | RA CAPITAL MANAGEMENT, L.P. | 486,557 | 8,831,000 | 3.27% | ||
| 11 | EcoR1 Capital, LLC | 473,123 | 8,587,000 | 3.18% | ||
| 12 | Cormorant Asset Management, LP | 450,000 | 8,168,000 | 3.03% | ||
| 13 | VANGUARD GROUP INC | 448,822 | 8,146,000 | 3.02% | ||
| 14 | MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 362,004 | 6,570,000 | 2.44% | ||
| 15 | Bank of New York Mellon Corp | 337,623 | 6,129,000 | 2.27% | ||
| 16 | SECTORAL ASSET MANAGEMENT INC | 294,400 | 5,343,000 | 1.98% | ||
| 17 | HIGHLAND CAPITAL MANAGEMENT LP | 256,125 | 4,649,000 | 1.72% | ||
| 18 | BlackRock Institutional Trust Company, N.A. | 185,348 | 3,364,000 | 1.25% | ||
| 19 | AGF INVESTMENTS INC. | 145,000 | 2,628,000 | 0.97% | ||
| 20 | TFS CAPITAL LLC | 127,568 | 2,315,000 | 0.86% | ||
| 21 | Informed Momentum Co LLC | 127,021 | 2,305,000 | 0.85% | ||
| 22 | STATE STREET CORP | 110,573 | 2,009,000 | 0.74% | ||
| 23 | LPL Financial LLC | 108,290 | 1,968,000 | 0.73% | ||
| 24 | NORTHERN TRUST CORP | 99,402 | 1,804,000 | 0.67% | ||
| 25 | SABBY MANAGEMENT, LLC | 82,100 | 1,490,000 | 0.55% | ||
| 26 | GEODE CAPITAL MANAGEMENT, LLC | 78,903 | 1,432,000 | 0.53% | ||
| 27 | Birchview Capital, LP | 76,768 | 1,393,000 | 0.52% | ||
| 28 | AMERIPRISE FINANCIAL INC | 75,865 | 1,377,000 | 0.51% | ||
| 29 | MONASHEE INVESTMENT MANAGEMENT LLC | 68,000 | 1,234,000 | 0.46% | PRN | |
| 30 | NBW CAPITAL LLC | 63,930 | 1,160,000 | 0.43% | ||
| 31 | GOLDMAN SACHS GROUP INC | 60,294 | 1,094,000 | 0.41% | ||
| 32 | Nicholas Investment Partners, LP | 46,773 | 849,000 | 0.31% | ||
| 33 | TOCQUEVILLE ASSET MANAGEMENT L.P. | 43,900 | 797,000 | 0.30% | ||
| 34 | RAYMOND JAMES & ASSOCIATES | 41,175 | 747,000 | 0.28% | ||
| 35 | WELLINGTON MANAGEMENT GROUP LLP | 34,700 | 629,000 | 0.23% | ||
| 36 | MYCIO WEALTH PARTNERS, LLC | 32,901 | 597,000 | 0.22% | ||
| 37 | MACQUARIE GROUP LTD | 30,353 | 551,000 | 0.20% | ||
| 38 | MORGAN STANLEY | 27,606 | 501,000 | 0.19% | ||
| 39 | BlackRock Investment Management, LLC | 26,158 | 475,000 | 0.18% | ||
| 40 | TIAA CREF INVESTMENT MANAGEMENT LLC | 23,486 | 426,000 | 0.16% | ||
| 41 | RUSSELL FRANK CO/ | 23,263 | 422,000 | 0.16% | ||
| 42 | D. E. Shaw & Co., Inc. | 19,383 | 352,000 | 0.13% | ||
| 43 | ProShare Advisors LLC | 18,313 | 332,000 | 0.12% | ||
| 44 | PARAMETRIC PORTFOLIO ASSOCIATES LLC | 17,927 | 325,000 | 0.12% | ||
| 45 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 16,137 | 293,000 | 0.11% | ||
| 46 | M&T BANK CORP | 15,820 | 287,000 | 0.11% | ||
| 47 | ROYAL BANK OF CANADA | 11,300 | 205,000 | 0.08% | ||
| 48 | TEACHERS ADVISORS, LLC | 11,249 | 204,000 | 0.08% | ||
| 49 | DekaBank Deutsche Girozentrale | 10,100 | 172,000 | 0.06% | ||
| 50 | CITIGROUP INC | 9,208 | 167,000 | 0.06% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
