| 1 |
RA CAPITAL MANAGEMENT, L.P. |
1,545,410 |
27,570,000 |
16.66% |
|
|
| 2 |
TPG Group Holdings (SBS) Advisors, Inc. |
1,325,263 |
23,643,000 |
14.29% |
|
|
| 3 |
ADAGE CAPITAL PARTNERS GP, L.L.C. |
858,091 |
15,308,000 |
9.25% |
|
|
| 4 |
Rock Springs Capital Management LP |
754,600 |
13,462,000 |
8.14% |
|
|
| 5 |
EVENTIDE ASSET MANAGEMENT, LLC |
745,802 |
13,305,000 |
8.04% |
|
|
| 6 |
MASSACHUSETTS FINANCIAL SERVICES CO /MA/ |
488,510 |
8,715,019 |
5.27% |
|
|
| 7 |
HealthCor Management, L.P. |
473,664 |
8,450,000 |
5.11% |
|
|
| 8 |
EcoR1 Capital, LLC |
465,118 |
8,298,000 |
5.01% |
|
|
| 9 |
FMR LLC |
450,000 |
8,028,000 |
4.85% |
|
|
| 10 |
Cormorant Asset Management, LP |
450,000 |
8,028,000 |
4.85% |
|
|
| 11 |
FRANKLIN RESOURCES INC |
330,600 |
5,898,000 |
3.56% |
|
|
| 12 |
Broadfin Capital, LLC |
297,200 |
5,302,000 |
3.20% |
|
|
| 13 |
BlackRock Fund Advisors |
176,976 |
3,157,000 |
1.91% |
|
|
| 14 |
ACUTA CAPITAL PARTNERS, LLC |
130,000 |
2,319,000 |
1.40% |
|
|
| 15 |
Lombard Odier Asset Management (USA) Corp |
125,000 |
2,230,000 |
1.35% |
|
|
| 16 |
Pentwater Capital Management LP |
100,000 |
1,784,000 |
1.08% |
|
|
| 17 |
VANGUARD GROUP INC |
81,618 |
1,457,000 |
0.88% |
|
|
| 18 |
Birchview Capital, LP |
78,768 |
1,405,000 |
0.85% |
|
|
| 19 |
NBW CAPITAL LLC |
67,267 |
1,200,000 |
0.73% |
|
|
| 20 |
STATE STREET CORP |
44,506 |
794,000 |
0.48% |
|
|
| 21 |
GOLDMAN SACHS GROUP INC |
40,430 |
721,000 |
0.44% |
|
|
| 22 |
BlackRock Institutional Trust Company, N.A. |
41,268 |
637,000 |
0.38% |
|
|
| 23 |
Spark Investment Management LLC |
34,200 |
608,000 |
0.37% |
|
|
| 24 |
MORGAN STANLEY |
30,263 |
540,000 |
0.33% |
|
|
| 25 |
BlackRock Investment Management, LLC |
25,479 |
455,000 |
0.27% |
|
|
| 26 |
Bank of New York Mellon Corp |
23,774 |
424,000 |
0.26% |
|
|
| 27 |
TOCQUEVILLE ASSET MANAGEMENT L.P. |
21,000 |
375,000 |
0.23% |
|
|
| 28 |
NORGES BANK |
20,000 |
357,000 |
0.22% |
|
|
| 29 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
12,182 |
217,000 |
0.13% |
|
|
| 30 |
TEACHERS ADVISORS, LLC |
9,649 |
172,000 |
0.10% |
|
|
| 31 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
7,193 |
128,000 |
0.08% |
|
|
| 32 |
PIPER SANDLER & CO. |
5,596 |
100,000 |
0.06% |
|
|
| 33 |
Nationwide Fund Advisors |
4,269 |
76,000 |
0.05% |
|
|
| 34 |
NEW YORK STATE COMMON RETIREMENT FUND |
4,076 |
73,000 |
0.04% |
|
|
| 35 |
AMERICAN INTERNATIONAL GROUP, INC. |
3,909 |
69,737 |
0.04% |
|
|
| 36 |
BLACKROCK ADVISORS LLC |
3,371 |
60,000 |
0.04% |
|
|
| 37 |
STRS OHIO |
2,100 |
37,000 |
0.02% |
|
|
| 38 |
DEUTSCHE BANK AG\ |
1,603 |
28,000 |
0.02% |
|
|
| 39 |
Tower Research Capital LLC (TRC) |
506 |
9,000 |
0.01% |
|
|
| 40 |
ROYAL BANK OF CANADA |
452 |
8,000 |
0.00% |
|
|
| 41 |
Invesco Ltd. |
310 |
6,000 |
0.00% |
|
|
| 42 |
WELLS FARGO & COMPANY/MN |
334 |
6,000 |
0.00% |
|
|
| 43 |
BANK OF AMERICA CORP /DE/ |
184 |
3,000 |
0.00% |
|
|
| 44 |
BARCLAYS PLC |
128 |
2,000 |
0.00% |
|
|
| 45 |
Gemmer Asset Management LLC |
100 |
2,000 |
0.00% |
|
SH |
| 46 |
CITIGROUP INC |
87 |
2,000 |
0.00% |
|
|
