| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | SECTORAL ASSET MANAGEMENT INC | 2,104,756 | 32,771,000 | 9.01% | ||
| 2 | EVENTIDE ASSET MANAGEMENT, LLC | 2,077,751 | 32,351,000 | 8.89% | ||
| 3 | FRAZIER MANAGEMENT LLC | 1,887,332 | 29,386,000 | 8.08% | ||
| 4 | FRANKLIN RESOURCES INC | 1,797,902 | 27,994,000 | 7.69% | ||
| 5 | Rock Springs Capital Management LP | 1,600,000 | 24,912,000 | 6.85% | ||
| 6 | HealthCor Management, L.P. | 1,426,300 | 22,207,000 | 6.10% | ||
| 7 | PFM Health Sciences, LP | 1,418,141 | 22,080,000 | 6.07% | ||
| 8 | TPG Group Holdings (SBS) Advisors, Inc. | 1,389,863 | 21,640,000 | 5.95% | ||
| 9 | BlackRock Fund Advisors | 931,081 | 14,497,000 | 3.98% | ||
| 10 | CADIAN CAPITAL MANAGEMENT, LP | 919,001 | 14,309,000 | 3.93% | ||
| 11 | FMR LLC | 915,673 | 14,257,000 | 3.92% | ||
| 12 | VANGUARD GROUP INC | 748,141 | 11,648,000 | 3.20% | ||
| 13 | HIGHLAND CAPITAL MANAGEMENT LP | 684,909 | 10,664,000 | 2.93% | ||
| 14 | EverPoint Asset Management, LLC | 460,000 | 7,162,000 | 1.97% | ||
| 15 | Cormorant Asset Management, LP | 455,515 | 7,092,000 | 1.95% | ||
| 16 | MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 449,127 | 6,993,000 | 1.92% | ||
| 17 | BlackRock Institutional Trust Company, N.A. | 412,376 | 6,421,000 | 1.76% | ||
| 18 | PRUDENTIAL FINANCIAL INC | 341,860 | 5,323,000 | 1.46% | ||
| 19 | BUCKINGHAM CAPITAL MANAGEMENT INC | 330,878 | 5,152,000 | 1.42% | ||
| 20 | Pier Capital, LLC | 329,629 | 5,132,000 | 1.41% | ||
| 21 | STATE STREET CORP | 289,219 | 4,530,000 | 1.25% | ||
| 22 | J. Goldman & Co LP | 224,850 | 3,501,000 | 0.96% | ||
| 23 | NORTHERN TRUST CORP | 215,463 | 3,355,000 | 0.92% | ||
| 24 | PERCEPTIVE ADVISORS LLC | 196,728 | 3,063,000 | 0.84% | ||
| 25 | GEODE CAPITAL MANAGEMENT, LLC | 141,702 | 2,206,000 | 0.61% | ||
| 26 | MOORE CAPITAL MANAGEMENT, LP | 125,000 | 1,946,000 | 0.53% | ||
| 27 | LPL Financial LLC | 118,703 | 1,861,000 | 0.51% | ||
| 28 | MORGAN STANLEY | 112,804 | 1,757,000 | 0.48% | ||
| 29 | DEUTSCHE BANK AG\ | 105,662 | 1,643,000 | 0.45% | ||
| 30 | TOCQUEVILLE ASSET MANAGEMENT L.P. | 78,000 | 1,214,000 | 0.33% | ||
| 31 | Jefferies Group LLC | 75,811 | 1,180,000 | 0.32% | ||
| 32 | RAYMOND JAMES & ASSOCIATES | 66,365 | 1,033,000 | 0.28% | ||
| 33 | Bank of New York Mellon Corp | 61,530 | 958,000 | 0.26% | ||
| 34 | NBW CAPITAL LLC | 60,916 | 948,000 | 0.26% | ||
| 35 | BlackRock Investment Management, LLC | 58,611 | 913,000 | 0.25% | ||
| 36 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 45,036 | 702,000 | 0.19% | ||
| 37 | BARCLAYS PLC | 45,000 | 701,000 | 0.19% | Put | |
| 38 | TIAA CREF INVESTMENT MANAGEMENT LLC | 43,995 | 685,000 | 0.19% | ||
| 39 | GOLDMAN SACHS GROUP INC | 35,646 | 555,000 | 0.15% | ||
| 40 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 33,995 | 529,000 | 0.15% | ||
| 41 | Swiss National Bank | 30,300 | 472,000 | 0.13% | ||
| 42 | NORGES BANK | 30,000 | 467,000 | 0.13% | ||
| 43 | M&T BANK CORP | 28,373 | 442,000 | 0.12% | ||
| 44 | Point72 Asset Management, L.P. | 28,000 | 436,000 | 0.12% | ||
| 45 | MILLENNIUM MANAGEMENT LLC | 26,368 | 411,000 | 0.11% | ||
| 46 | TEACHERS ADVISORS, LLC | 25,437 | 396,000 | 0.11% | ||
| 47 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 23,830 | 371,000 | 0.10% | ||
| 48 | Partner Investment Management, L.P. | 23,769 | 370,000 | 0.10% | ||
| 49 | TFS CAPITAL LLC | 22,577 | 352,000 | 0.10% | ||
| 50 | ProShare Advisors LLC | 21,546 | 335,000 | 0.09% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
