| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 3,889,458 | 200,307,000 | 44.26% | ||
| 2 | FEDERATED HERMES, INC. | 1,100,000 | 56,650,000 | 12.52% | ||
| 3 | GILDER GAGNON HOWE & CO LLC | 765,952 | 39,447,000 | 8.72% | ||
| 4 | DEERFIELD MANAGEMENT COMPANY, L.P. | 642,608 | 33,094,000 | 7.31% | ||
| 5 | ORBIMED ADVISORS LLC | 512,900 | 26,414,000 | 5.84% | ||
| 6 | BAKER BROS. ADVISORS LP | 369,276 | 19,018,000 | 4.20% | ||
| 7 | RS INVESTMENT MANAGEMENT CO LLC | 282,340 | 14,541,000 | 3.21% | ||
| 8 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 225,000 | 11,588,000 | 2.56% | ||
| 9 | GOLDMAN SACHS GROUP INC | 169,582 | 8,733,000 | 1.93% | ||
| 10 | Rock Springs Capital Management LP | 152,500 | 7,854,000 | 1.74% | ||
| 11 | FRANKLIN RESOURCES INC | 150,000 | 7,725,000 | 1.71% | ||
| 12 | Zweig-DiMenna Associates LLC | 140,000 | 7,210,000 | 1.59% | ||
| 13 | BLACKROCK ADVISORS LLC | 53,000 | 2,730,000 | 0.60% | ||
| 14 | Atika Capital Management LLC | 40,100 | 2,065,000 | 0.46% | ||
| 15 | Alyeska Investment Group, L.P. | 39,320 | 2,025,000 | 0.45% | ||
| 16 | BlackRock Group LTD | 33,300 | 1,715,000 | 0.38% | ||
| 17 | MILLENNIUM MANAGEMENT LLC | 32,695 | 1,684,000 | 0.37% | ||
| 18 | PERCEPTIVE ADVISORS LLC | 20,000 | 1,030,000 | 0.23% | ||
| 19 | Tekla Capital Management LLC | 20,000 | 1,030,000 | 0.23% | ||
| 20 | Weiss Multi-Strategy Advisers LLC | 20,000 | 1,030,000 | 0.23% | ||
| 21 | OMERS ADMINISTRATION Corp | 15,400 | 793,000 | 0.18% | ||
| 22 | LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 15,300 | 788,000 | 0.17% | ||
| 23 | BNP Paribas Asset Management Holding S.A. | 13,127 | 676,000 | 0.15% | ||
| 24 | MORGAN STANLEY | 12,498 | 644,000 | 0.14% | ||
| 25 | NAVELLIER & ASSOCIATES INC | 12,035 | 620,000 | 0.14% | ||
| 26 | GLG Partners LP | 11,219 | 578,000 | 0.13% | ||
| 27 | CITADEL ADVISORS LLC | 10,511 | 541,000 | 0.12% | ||
| 28 | DEUTSCHE BANK AG\ | 10,000 | 515,000 | 0.11% | ||
| 29 | BlackRock Finance, Inc. | 9,600 | 494,000 | 0.11% | ||
| 30 | Geduld E E | 5,000 | 258,000 | 0.06% | ||
| 31 | FolioMetrix LLC | 3,400 | 189,000 | 0.04% | ||
| 32 | BlackRock Investment Management, LLC | 3,400 | 175,000 | 0.04% | ||
| 33 | UBS Group AG | 2,500 | 129,000 | 0.03% | ||
| 34 | BARCLAYS PLC | 2,300 | 117,000 | 0.03% | ||
| 35 | WELLS FARGO & COMPANY/MN | 950 | 49,000 | 0.01% | ||
| 36 | Invesco Ltd. | 839 | 43,000 | 0.01% | ||
| 37 | ROYAL BANK OF CANADA | 420 | 22,000 | 0.00% | ||
| 38 | PRELUDE CAPITAL MANAGEMENT, LLC | 300 | 15,000 | 0.00% | ||
| 39 | Edge Wealth Management LLC | 200 | 10,000 | 0.00% | ||
| 40 | LADENBURG THALMANN FINANCIAL SERVICES INC. | 50 | 3,000 | 0.00% | ||
| 41 | Rail-Splitter Capital Management, LLC | 22,041 | 0 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
