| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 4,583,704 | 191,691,000 | 52.29% | ||
| 2 | FEDERATED HERMES, INC. | 1,102,773 | 46,118,000 | 12.58% | ||
| 3 | WELLINGTON MANAGEMENT GROUP LLP | 800,199 | 33,465,000 | 9.13% | ||
| 4 | GOLDMAN SACHS GROUP INC | 349,763 | 14,627,000 | 3.99% | ||
| 5 | DEERFIELD MANAGEMENT COMPANY, L.P. | 327,626 | 13,701,000 | 3.74% | ||
| 6 | BAKER BROS. ADVISORS LP | 303,394 | 12,688,000 | 3.46% | ||
| 7 | EcoR1 Capital, LLC | 246,691 | 10,317,000 | 2.81% | ||
| 8 | ORBIMED ADVISORS LLC | 230,000 | 9,619,000 | 2.62% | ||
| 9 | Rock Springs Capital Management LP | 210,000 | 8,782,000 | 2.40% | ||
| 10 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 150,000 | 6,273,000 | 1.71% | ||
| 11 | DAFNA Capital Management LLC | 65,568 | 2,742,000 | 0.75% | ||
| 12 | MORGAN STANLEY | 54,118 | 2,262,000 | 0.62% | ||
| 13 | CLOUGH CAPITAL PARTNERS L P | 53,970 | 2,257,000 | 0.62% | ||
| 14 | EVENTIDE ASSET MANAGEMENT, LLC | 52,000 | 2,175,000 | 0.59% | ||
| 15 | MACQUARIE GROUP LTD | 46,955 | 1,964,000 | 0.54% | ||
| 16 | ALPS ADVISORS INC | 43,874 | 1,835,000 | 0.50% | ||
| 17 | NORTHERN TRUST CORP | 24,401 | 1,020,000 | 0.28% | ||
| 18 | Rail-Splitter Capital Management, LLC | 21,564 | 902,000 | 0.25% | ||
| 19 | Tekla Capital Management LLC | 20,000 | 836,000 | 0.23% | ||
| 20 | LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 17,389 | 727,000 | 0.20% | ||
| 21 | Weiss Multi-Strategy Advisers LLC | 14,500 | 606,000 | 0.17% | ||
| 22 | DEUTSCHE BANK AG\ | 13,650 | 570,000 | 0.16% | ||
| 23 | A.R.T. Advisors, LLC | 13,100 | 547,000 | 0.15% | ||
| 24 | STEVENS CAPITAL MANAGEMENT LP | 8,793 | 368,000 | 0.10% | ||
| 25 | UBS Group AG | 4,424 | 185,000 | 0.05% | ||
| 26 | CASTLEARK MANAGEMENT LLC | 3,700 | 155,000 | 0.04% | ||
| 27 | BANK OF MONTREAL /CAN/ | 1,677 | 70,000 | 0.02% | ||
| 28 | Creative Planning | 1,400 | 59,000 | 0.02% | ||
| 29 | BANK OF AMERICA CORP /DE/ | 581 | 24,000 | 0.01% | ||
| 30 | GENEOS WEALTH MANAGEMENT INC. | 400 | 16,000 | 0.00% | ||
| 31 | Tower Research Capital LLC (TRC) | 200 | 8,000 | 0.00% | ||
| 32 | NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 200 | 8,000 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
