| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 4,610,950 | 255,769,000 | 47.11% | ||
| 2 | FEDERATED HERMES, INC. | 1,102,773 | 61,171,000 | 11.27% | ||
| 3 | WELLINGTON MANAGEMENT GROUP LLP | 767,579 | 42,578,000 | 7.84% | ||
| 4 | DEERFIELD MANAGEMENT COMPANY, L.P. | 458,112 | 25,411,000 | 4.68% | ||
| 5 | EcoR1 Capital, LLC | 439,385 | 24,373,000 | 4.49% | ||
| 6 | ORBIMED ADVISORS LLC | 352,700 | 19,564,000 | 3.60% | ||
| 7 | Cormorant Asset Management, LP | 334,044 | 18,347,000 | 3.38% | ||
| 8 | GOLDMAN SACHS GROUP INC | 300,118 | 16,648,000 | 3.07% | ||
| 9 | BAKER BROS. ADVISORS LP | 259,894 | 14,416,000 | 2.66% | ||
| 10 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 235,000 | 13,035,000 | 2.40% | ||
| 11 | Rock Springs Capital Management LP | 210,000 | 11,649,000 | 2.15% | ||
| 12 | Tekla Capital Management LLC | 147,738 | 8,195,000 | 1.51% | ||
| 13 | Bank of New York Mellon Corp | 65,501 | 3,634,000 | 0.67% | ||
| 14 | CLOUGH CAPITAL PARTNERS L P | 64,970 | 3,604,000 | 0.66% | ||
| 15 | ALPS ADVISORS INC | 64,775 | 3,593,000 | 0.66% | ||
| 16 | DAFNA Capital Management LLC | 63,568 | 3,526,000 | 0.65% | ||
| 17 | MORGAN STANLEY | 59,975 | 3,327,000 | 0.61% | ||
| 18 | EVENTIDE ASSET MANAGEMENT, LLC | 52,000 | 2,884,000 | 0.53% | ||
| 19 | WILLIAMS JONES & ASSOCIATES LLC | 43,779 | 2,428,000 | 0.45% | ||
| 20 | NORTHERN TRUST CORP | 23,512 | 1,304,000 | 0.24% | ||
| 21 | Atika Capital Management LLC | 21,000 | 1,165,000 | 0.21% | ||
| 22 | P.A.W. CAPITAL CORP | 20,000 | 1,109,000 | 0.20% | ||
| 23 | Rail-Splitter Capital Management, LLC | 18,969 | 1,052,000 | 0.19% | ||
| 24 | LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 16,149 | 896,000 | 0.17% | ||
| 25 | DEUTSCHE BANK AG\ | 14,950 | 828,000 | 0.15% | ||
| 26 | Weiss Multi-Strategy Advisers LLC | 8,748 | 485,000 | 0.09% | ||
| 27 | RENAISSANCE TECHNOLOGIES LLC | 8,100 | 449,000 | 0.08% | ||
| 28 | CITADEL ADVISORS LLC | 6,254 | 347,000 | 0.06% | ||
| 29 | Fiera Capital Corp | 5,449 | 302,000 | 0.06% | ||
| 30 | UBS Group AG | 4,920 | 273,000 | 0.05% | ||
| 31 | CASTLEARK MANAGEMENT LLC | 3,700 | 205,000 | 0.04% | ||
| 32 | GEODE CAPITAL MANAGEMENT, LLC | 3,654 | 202,000 | 0.04% | ||
| 33 | Creative Planning | 1,400 | 78,000 | 0.01% | ||
| 34 | BANK OF MONTREAL /CAN/ | 681 | 38,000 | 0.01% | ||
| 35 | BANK OF AMERICA CORP /DE/ | 627 | 35,000 | 0.01% | ||
| 36 | GENEOS WEALTH MANAGEMENT INC. | 400 | 21,000 | 0.00% | ||
| 37 | BlackRock Finance, Inc. | 300 | 17,000 | 0.00% | ||
| 38 | Tower Research Capital LLC (TRC) | 185 | 11,000 | 0.00% | ||
| 39 | WOLVERINE TRADING LP /BD | 100 | 5,418 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
