| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 3,907,634 | 245,712,000 | 47.44% | ||
| 2 | FEDERATED HERMES, INC. | 1,102,773 | 69,342,000 | 13.39% | ||
| 3 | WELLINGTON MANAGEMENT GROUP LLP | 622,543 | 39,145,000 | 7.56% | ||
| 4 | BAKER BROS. ADVISORS LP | 369,276 | 23,220,000 | 4.48% | ||
| 5 | GOLDMAN SACHS GROUP INC | 369,086 | 23,208,000 | 4.48% | ||
| 6 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 300,000 | 18,864,000 | 3.64% | ||
| 7 | ORBIMED ADVISORS LLC | 230,000 | 14,462,000 | 2.79% | ||
| 8 | Rock Springs Capital Management LP | 210,000 | 13,205,000 | 2.55% | ||
| 9 | DEERFIELD MANAGEMENT COMPANY, L.P. | 183,000 | 11,507,000 | 2.22% | ||
| 10 | EcoR1 Capital, LLC | 167,361 | 10,524,000 | 2.03% | ||
| 11 | CLOUGH CAPITAL PARTNERS L P | 125,800 | 7,910,000 | 1.53% | ||
| 12 | MORGAN STANLEY | 112,640 | 7,083,000 | 1.37% | ||
| 13 | GLG Partners LP | 70,309 | 4,421,000 | 0.85% | ||
| 14 | Point72 Asset Management, L.P. | 63,600 | 3,999,000 | 0.77% | ||
| 15 | ALPS ADVISORS INC | 51,393 | 3,232,000 | 0.62% | ||
| 16 | EverPoint Asset Management, LLC | 49,981 | 3,143,000 | 0.61% | ||
| 17 | Atika Capital Management LLC | 42,000 | 2,641,000 | 0.51% | ||
| 18 | RENAISSANCE TECHNOLOGIES LLC | 37,900 | 2,383,000 | 0.46% | ||
| 19 | MACQUARIE GROUP LTD | 34,533 | 2,171,000 | 0.42% | ||
| 20 | DEUTSCHE BANK AG\ | 31,101 | 1,953,000 | 0.38% | ||
| 21 | DAFNA Capital Management LLC | 30,000 | 1,886,000 | 0.36% | ||
| 22 | DRIEHAUS CAPITAL MANAGEMENT LLC | 26,890 | 1,691,000 | 0.33% | ||
| 23 | Tekla Capital Management LLC | 20,000 | 1,258,000 | 0.24% | ||
| 24 | Weiss Multi-Strategy Advisers LLC | 14,500 | 912,000 | 0.18% | ||
| 25 | Rail-Splitter Capital Management, LLC | 12,849 | 808,000 | 0.16% | ||
| 26 | Geduld E E | 11,000 | 692,000 | 0.13% | ||
| 27 | LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 8,101 | 509,000 | 0.10% | ||
| 28 | Airain ltd | 7,541 | 474,000 | 0.09% | ||
| 29 | UBS Group AG | 4,456 | 280,000 | 0.05% | ||
| 30 | Cubist Systematic Strategies, LLC | 3,946 | 248,000 | 0.05% | ||
| 31 | NAVELLIER & ASSOCIATES INC | 3,400 | 214,000 | 0.04% | ||
| 32 | CAVALIER INVESTMENTS, LLC | 3,400 | 214,000 | 0.04% | ||
| 33 | GEODE CAPITAL MANAGEMENT, LLC | 3,353 | 210,000 | 0.04% | ||
| 34 | CASTLEARK MANAGEMENT LLC | 3,000 | 189,000 | 0.04% | ||
| 35 | Creative Planning | 1,400 | 88,000 | 0.02% | ||
| 36 | BANK OF MONTREAL /CAN/ | 659 | 41,000 | 0.01% | ||
| 37 | BlackRock Finance, Inc. | 500 | 31,000 | 0.01% | ||
| 38 | ROYAL BANK OF CANADA | 420 | 26,000 | 0.01% | ||
| 39 | BANK OF AMERICA CORP /DE/ | 250 | 16,000 | 0.00% | ||
| 40 | Walleye Trading LLC | 200 | 13,000 | 0.00% | ||
| 41 | Edge Wealth Management LLC | 200 | 13,000 | 0.00% | SH | |
| 42 | CITIGROUP INC | 49 | 3,000 | 0.00% | ||
| 43 | US BANCORP \DE\ | 46 | 3,000 | 0.00% | ||
| 44 | WELLS FARGO & COMPANY/MN | 6 | 0 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
