| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 4,616,982 | 298,534,000 | 47.56% | ||
| 2 | FEDERATED HERMES, INC. | 1,102,773 | 71,305,000 | 11.36% | ||
| 3 | EcoR1 Capital, LLC | 500,576 | 32,367,000 | 5.16% | ||
| 4 | WELLINGTON MANAGEMENT GROUP LLP | 468,982 | 30,324,000 | 4.83% | ||
| 5 | ORBIMED ADVISORS LLC | 457,900 | 29,608,000 | 4.72% | ||
| 6 | DEERFIELD MANAGEMENT COMPANY, L.P. | 423,112 | 27,358,000 | 4.36% | ||
| 7 | Cormorant Asset Management, LP | 334,044 | 21,441,000 | 3.42% | ||
| 8 | GOLDMAN SACHS GROUP INC | 289,338 | 18,709,000 | 2.98% | ||
| 9 | BAKER BROS. ADVISORS LP | 259,894 | 16,805,000 | 2.68% | ||
| 10 | Rock Springs Capital Management LP | 210,000 | 13,579,000 | 2.16% | ||
| 11 | Tekla Capital Management LLC | 147,738 | 9,553,000 | 1.52% | ||
| 12 | RENAISSANCE TECHNOLOGIES LLC | 140,200 | 9,065,000 | 1.44% | ||
| 13 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 85,000 | 5,496,000 | 0.88% | ||
| 14 | DEUTSCHE BANK AG\ | 66,940 | 4,327,000 | 0.69% | ||
| 15 | DAFNA Capital Management LLC | 66,068 | 4,272,000 | 0.68% | ||
| 16 | MORGAN STANLEY | 63,406 | 4,100,000 | 0.65% | ||
| 17 | Bank of New York Mellon Corp | 63,087 | 4,080,000 | 0.65% | ||
| 18 | ALPS ADVISORS INC | 58,782 | 3,801,000 | 0.61% | ||
| 19 | EVENTIDE ASSET MANAGEMENT, LLC | 52,000 | 3,362,000 | 0.54% | ||
| 20 | Atika Capital Management LLC | 52,000 | 3,362,000 | 0.54% | ||
| 21 | J. Goldman & Co LP | 50,000 | 3,233,000 | 0.52% | ||
| 22 | CLOUGH CAPITAL PARTNERS L P | 48,170 | 3,115,000 | 0.50% | ||
| 23 | WILLIAMS JONES & ASSOCIATES LLC | 44,757 | 2,894,000 | 0.46% | ||
| 24 | NORTHERN TRUST CORP | 14,673 | 949,000 | 0.15% | ||
| 25 | Weiss Multi-Strategy Advisers LLC | 13,000 | 841,000 | 0.13% | ||
| 26 | P.A.W. CAPITAL CORP | 12,000 | 776,000 | 0.12% | ||
| 27 | SCHONFELD STRATEGIC ADVISORS LLC | 9,398 | 608,000 | 0.10% | ||
| 28 | BlackRock Institutional Trust Company, N.A. | 8,793 | 569,000 | 0.09% | ||
| 29 | UBS Group AG | 7,762 | 502,000 | 0.08% | ||
| 30 | CITADEL ADVISORS LLC | 6,374 | 412,000 | 0.07% | ||
| 31 | MARSHALL WACE, LLP | 6,029 | 390,000 | 0.06% | ||
| 32 | Fiera Capital Corp | 3,842 | 248,000 | 0.04% | ||
| 33 | GEODE CAPITAL MANAGEMENT, LLC | 3,681 | 238,000 | 0.04% | ||
| 34 | Rail-Splitter Capital Management, LLC | 3,649 | 236,000 | 0.04% | ||
| 35 | Polar Asset Management Partners Inc. | 3,500 | 226,000 | 0.04% | ||
| 36 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 3,434 | 222,000 | 0.04% | ||
| 37 | CASTLEARK MANAGEMENT LLC | 3,330 | 215,000 | 0.03% | ||
| 38 | PRELUDE CAPITAL MANAGEMENT, LLC | 2,412 | 156,000 | 0.02% | ||
| 39 | Advisors Preferred, LLC | 2,019 | 131,000 | 0.02% | ||
| 40 | Creative Planning | 1,200 | 78,000 | 0.01% | ||
| 41 | BANK OF AMERICA CORP /DE/ | 1,002 | 64,000 | 0.01% | ||
| 42 | Walleye Trading LLC | 800 | 52,000 | 0.01% | ||
| 43 | ADVISOR GROUP, INC. | 705 | 46,000 | 0.01% | ||
| 44 | ACROSPIRE INVESTMENT MANAGEMENT LLC | 700 | 45,000 | 0.01% | ||
| 45 | GENEOS WEALTH MANAGEMENT INC. | 400 | 25,000 | 0.00% | ||
| 46 | Tower Research Capital LLC (TRC) | 304 | 20,000 | 0.00% | ||
| 47 | BANK OF MONTREAL /CAN/ | 22 | 1,000 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
