| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 4,625,607 | 398,681,000 | 45.87% | ||
| 2 | FEDERATED HERMES, INC. | 997,800 | 86,000,000 | 9.90% | ||
| 3 | EcoR1 Capital, LLC | 551,041 | 47,494,000 | 5.46% | ||
| 4 | WELLINGTON MANAGEMENT GROUP LLP | 458,088 | 39,483,000 | 4.54% | ||
| 5 | RENAISSANCE TECHNOLOGIES LLC | 311,200 | 26,822,000 | 3.09% | ||
| 6 | Cormorant Asset Management, LP | 300,000 | 26,070,000 | 3.00% | ||
| 7 | ORBIMED ADVISORS LLC | 283,500 | 24,435,000 | 2.81% | ||
| 8 | PERCEPTIVE ADVISORS LLC | 271,405 | 23,392,000 | 2.69% | ||
| 9 | BAKER BROS. ADVISORS LP | 259,894 | 22,400,000 | 2.58% | ||
| 10 | DEERFIELD MANAGEMENT COMPANY, L.P. | 259,768 | 22,389,000 | 2.58% | ||
| 11 | Rock Springs Capital Management LP | 210,000 | 18,100,000 | 2.08% | ||
| 12 | GOLDMAN SACHS GROUP INC | 200,938 | 17,319,000 | 1.99% | ||
| 13 | BlackRock Finance, Inc. | 149,500 | 12,886,000 | 1.48% | ||
| 14 | FARALLON CAPITAL MANAGEMENT LLC | 120,000 | 10,343,000 | 1.19% | ||
| 15 | Tekla Capital Management LLC | 115,738 | 9,975,000 | 1.15% | ||
| 16 | PEREGRINE CAPITAL MANAGEMENT INC /MN/ | 115,049 | 9,878,000 | 1.14% | ||
| 17 | WILLIAMS JONES & ASSOCIATES LLC | 88,782 | 7,652,000 | 0.88% | ||
| 18 | CLOUGH CAPITAL PARTNERS L P | 74,870 | 6,453,000 | 0.74% | ||
| 19 | DEUTSCHE BANK AG\ | 63,540 | 5,473,000 | 0.63% | ||
| 20 | Employees Retirement System of Texas | 56,000 | 4,827,000 | 0.56% | ||
| 21 | Bain Capital Public Equity Management, LLC | 54,600 | 4,706,000 | 0.54% | ||
| 22 | MORGAN STANLEY | 52,426 | 4,518,000 | 0.52% | ||
| 23 | EVENTIDE ASSET MANAGEMENT, LLC | 52,000 | 4,482,000 | 0.52% | ||
| 24 | GRATICULE ASIA MACRO ADVISORS LLC | 40,000 | 3,448,000 | 0.40% | ||
| 25 | ALPS ADVISORS INC | 39,668 | 3,419,000 | 0.39% | ||
| 26 | Bank of New York Mellon Corp | 37,920 | 3,269,000 | 0.38% | ||
| 27 | OLD MISSION CAPITAL LLC | 37,034 | 3,192,000 | 0.37% | ||
| 28 | DAFNA Capital Management LLC | 35,359 | 3,048,000 | 0.35% | ||
| 29 | Atika Capital Management LLC | 25,800 | 2,224,000 | 0.26% | ||
| 30 | P.A.W. CAPITAL CORP | 20,000 | 1,724,000 | 0.20% | ||
| 31 | NORTHERN TRUST CORP | 17,956 | 1,548,000 | 0.18% | ||
| 32 | ALLIANCEBERNSTEIN L.P. | 17,410 | 1,501,000 | 0.17% | ||
| 33 | Weiss Multi-Strategy Advisers LLC | 17,000 | 1,465,000 | 0.17% | ||
| 34 | MARSHALL WACE NORTH AMERICA, L.P. | 11,497 | 989,000 | 0.11% | ||
| 35 | MARSHALL WACE ASIA LTD | 11,497 | 989,000 | 0.11% | ||
| 36 | DRIEHAUS CAPITAL MANAGEMENT LLC | 10,928 | 942,000 | 0.11% | ||
| 37 | MACQUARIE GROUP LTD | 9,082 | 783,000 | 0.09% | ||
| 38 | Freedom Investment Management, Inc. | 8,032 | 692,000 | 0.08% | ||
| 39 | FRED ALGER MANAGEMENT, LLC | 7,500 | 646,000 | 0.07% | ||
| 40 | LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 6,589 | 568,000 | 0.07% | ||
| 41 | CASTLEARK MANAGEMENT LLC | 6,075 | 524,000 | 0.06% | ||
| 42 | GEODE CAPITAL MANAGEMENT, LLC | 5,057 | 435,000 | 0.05% | ||
| 43 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 4,541 | 391,000 | 0.04% | ||
| 44 | BANK OF AMERICA CORP /DE/ | 4,379 | 377,000 | 0.04% | ||
| 45 | BOGLE INVESTMENT MANAGEMENT L P /DE/ | 4,281 | 368,000 | 0.04% | ||
| 46 | UBS Group AG | 3,522 | 303,000 | 0.03% | ||
| 47 | OXFORD ASSET MANAGEMENT LLP | 3,479 | 300,000 | 0.03% | ||
| 48 | COOKSON PEIRCE & CO INC | 3,025 | 261,000 | 0.03% | SH | |
| 49 | CITADEL ADVISORS LLC | 2,775 | 239,000 | 0.03% | ||
| 50 | Airain ltd | 2,749 | 237,000 | 0.03% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
