| 1 |
Broadfin Capital, LLC |
2,008,125 |
21,868,000 |
14.56% |
|
|
| 2 |
FMR LLC |
2,141,645 |
21,673,000 |
14.43% |
|
|
| 3 |
WELLINGTON MANAGEMENT GROUP LLP |
1,612,896 |
17,564,000 |
11.70% |
|
|
| 4 |
Novo Holdings A/S |
900,000 |
9,801,000 |
6.53% |
|
|
| 5 |
MILLENNIUM MANAGEMENT LLC |
815,316 |
8,879,000 |
5.91% |
|
|
| 6 |
MARXE AUSTIN W & GREENHOUSE DAVID M |
810,000 |
8,821,000 |
5.87% |
|
|
| 7 |
JENNISON ASSOCIATES LLC |
725,936 |
7,905,000 |
5.26% |
|
|
| 8 |
PointState Capital LP |
626,400 |
6,821,000 |
4.54% |
|
|
| 9 |
VANGUARD GROUP INC |
429,363 |
4,676,000 |
3.11% |
|
|
| 10 |
BlackRock Fund Advisors |
402,148 |
4,379,000 |
2.92% |
|
|
| 11 |
BlackRock Institutional Trust Company, N.A. |
396,654 |
4,320,000 |
2.88% |
|
|
| 12 |
WELLS FARGO & COMPANY/MN |
383,615 |
4,177,000 |
2.78% |
|
|
| 13 |
HARVEY CAPITAL MANAGEMENT INC |
331,600 |
3,611,000 |
2.40% |
|
|
| 14 |
COLUMBIA PARTNERS L.L.C. INVESTMENT MANAGEMENT |
304,682 |
3,317,000 |
2.21% |
|
|
| 15 |
EVENTIDE ASSET MANAGEMENT, LLC |
300,900 |
3,277,000 |
2.18% |
|
|
| 16 |
NORTHERN TRUST CORP |
177,984 |
1,938,000 |
1.29% |
|
|
| 17 |
Opaleye Management Inc. |
160,000 |
1,757,000 |
1.17% |
|
|
| 18 |
STATE STREET CORP |
158,484 |
1,726,000 |
1.15% |
|
|
| 19 |
BANK OF AMERICA CORP /DE/ |
128,295 |
1,396,000 |
0.93% |
|
|
| 20 |
GREEN ARROW CAPITAL MANAGEMENT LLC |
125,000 |
1,361,000 |
0.91% |
|
|
| 21 |
BLACKROCK ADVISORS LLC |
96,126 |
1,047,000 |
0.70% |
|
|
| 22 |
SMITH ASSET MANAGEMENT GROUP LP |
94,187 |
1,026,000 |
0.68% |
|
|
| 23 |
GEODE CAPITAL MANAGEMENT, LLC |
82,182 |
894,000 |
0.60% |
|
|
| 24 |
Bank of New York Mellon Corp |
67,036 |
730,000 |
0.49% |
|
|
| 25 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
45,519 |
496,000 |
0.33% |
|
|
| 26 |
UNITED SERVICES AUTOMOBILE ASSOCIATION |
44,988 |
490,000 |
0.33% |
|
|
| 27 |
TFS CAPITAL LLC |
40,654 |
443,000 |
0.30% |
|
|
| 28 |
BlackRock Investment Management, LLC |
38,997 |
425,000 |
0.28% |
|
|
| 29 |
PACIFIC ALTERNATIVE ASSET MANAGEMENT COMPANY, LLC |
35,800 |
390,000 |
0.26% |
Call |
|
| 30 |
JPMORGAN CHASE & CO |
29,400 |
320,000 |
0.21% |
|
|
| 31 |
CREDIT SUISSE AG/ |
27,932 |
304,000 |
0.20% |
|
|
| 32 |
GOLDMAN SACHS GROUP INC |
26,943 |
293,000 |
0.20% |
|
|
| 33 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
25,371 |
276,000 |
0.18% |
|
|
| 34 |
Wilmington Funds Management Corp |
23,259 |
253,000 |
0.17% |
|
|
| 35 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
22,700 |
248,000 |
0.17% |
|
|
| 36 |
DUPONT CAPITAL MANAGEMENT CORP |
19,915 |
217,000 |
0.14% |
|
|
| 37 |
CITADEL ADVISORS LLC |
19,923 |
217,000 |
0.14% |
|
|
| 38 |
BARCLAYS PLC |
20,743 |
207,000 |
0.14% |
|
|
| 39 |
DRW Securities, LLC |
19,000 |
207,000 |
0.14% |
|
|
| 40 |
TEACHERS ADVISORS, LLC |
18,605 |
203,000 |
0.14% |
|
|
| 41 |
COWEN INC. |
18,400 |
200,000 |
0.13% |
|
|
| 42 |
Passport Capital, LLC |
17,431 |
190,000 |
0.13% |
|
|
| 43 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
17,046 |
186,000 |
0.12% |
|
|
| 44 |
ProShare Advisors LLC |
14,207 |
155,000 |
0.10% |
|
|
| 45 |
COMMONWEALTH BANK OF AUSTRALIA |
13,800 |
150,000 |
0.10% |
|
|
| 46 |
Independent Portfolio Consultants, Inc. |
12,965 |
141,000 |
0.09% |
|
|
| 47 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
11,742 |
128,000 |
0.09% |
|
|
| 48 |
Nationwide Fund Advisors |
10,709 |
117,000 |
0.08% |
|
|
| 49 |
RHUMBLINE ADVISERS |
10,453 |
114,000 |
0.08% |
|
|
| 50 |
PRELUDE CAPITAL MANAGEMENT, LLC |
10,005 |
109,000 |
0.07% |
|
|
