| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | WELLINGTON MANAGEMENT GROUP LLP | 4,896,987 | 36,531,000 | 16.65% | ||
| 2 | STATE STREET CORP | 3,662,875 | 27,319,000 | 12.45% | ||
| 3 | FMR LLC | 2,148,534 | 16,028,000 | 7.30% | ||
| 4 | BlackRock Fund Advisors | 2,087,330 | 15,571,000 | 7.10% | ||
| 5 | VANGUARD GROUP INC | 2,054,608 | 15,328,000 | 6.98% | ||
| 6 | BB BIOTECH AG | 1,482,114 | 11,057,000 | 5.04% | ||
| 7 | GREAT POINT PARTNERS LLC | 1,120,000 | 8,355,000 | 3.81% | ||
| 8 | BlackRock Institutional Trust Company, N.A. | 888,999 | 6,632,000 | 3.02% | ||
| 9 | Granahan Investment Management, LLC | 850,601 | 6,345,000 | 2.89% | ||
| 10 | SECTORAL ASSET MANAGEMENT INC | 692,036 | 5,163,000 | 2.35% | ||
| 11 | C WorldWide Group Holding A/S | 625,510 | 4,666,000 | 2.13% | ||
| 12 | NORTHERN TRUST CORP | 446,675 | 3,332,000 | 1.52% | ||
| 13 | Numeric Investors LLC | 417,300 | 3,113,000 | 1.42% | ||
| 14 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 355,398 | 2,651,000 | 1.21% | ||
| 15 | NORGES BANK | 343,232 | 2,561,000 | 1.17% | ||
| 16 | FARALLON CAPITAL MANAGEMENT LLC | 317,400 | 2,368,000 | 1.08% | ||
| 17 | HARVEY CAPITAL MANAGEMENT INC | 301,100 | 2,246,000 | 1.02% | ||
| 18 | Gruss Capital Management LP | 300,000 | 2,238,000 | 1.02% | ||
| 19 | COMMERZBANK AKTIENGESELLSCHAFT /FI | 293,327 | 2,188,000 | 1.00% | ||
| 20 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 280,400 | 2,092,000 | 0.95% | Put | |
| 21 | MILLENNIUM MANAGEMENT LLC | 246,281 | 1,837,000 | 0.84% | ||
| 22 | BANK OF MONTREAL /CAN/ | 236,378 | 1,764,000 | 0.80% | ||
| 23 | GEODE CAPITAL MANAGEMENT, LLC | 226,849 | 1,692,000 | 0.77% | ||
| 24 | Rhenman & Partners Asset Management AB | 225,000 | 1,679,000 | 0.77% | ||
| 25 | A.R.T. Advisors, LLC | 203,708 | 1,519,000 | 0.69% | ||
| 26 | Tekla Capital Management LLC | 192,322 | 1,435,000 | 0.65% | PRN | |
| 27 | TIAA CREF INVESTMENT MANAGEMENT LLC | 182,196 | 1,359,000 | 0.62% | ||
| 28 | Jump Trading, LLC | 501 | 1,354,000 | 0.62% | Put | |
| 29 | UNITED SERVICES AUTOMOBILE ASSOCIATION | 175,777 | 1,311,000 | 0.60% | ||
| 30 | EVENTIDE ASSET MANAGEMENT, LLC | 174,000 | 1,298,000 | 0.59% | ||
| 31 | DRIEHAUS CAPITAL MANAGEMENT LLC | 172,232 | 1,285,000 | 0.59% | ||
| 32 | Broadfin Capital, LLC | 160,047 | 1,194,000 | 0.54% | ||
| 33 | Bank of New York Mellon Corp | 159,678 | 1,191,000 | 0.54% | ||
| 34 | Jump Trading, LLC | 38,527 | 1,038,000 | 0.47% | ||
| 35 | Jump Trading, LLC | 359 | 1,014,000 | 0.46% | Call | |
| 36 | NumerixS Investment Technologies Inc | 133,863 | 999,000 | 0.46% | ||
| 37 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 131,973 | 985,000 | 0.45% | ||
| 38 | AQR CAPITAL MANAGEMENT LLC | 122,545 | 914,000 | 0.42% | ||
| 39 | BlackRock Investment Management, LLC | 120,115 | 896,000 | 0.41% | ||
| 40 | Candriam S.C.A. | 108,600 | 810,000 | 0.37% | ||
| 41 | TEACHERS ADVISORS, LLC | 101,923 | 760,000 | 0.35% | ||
| 42 | BANK OF AMERICA CORP /DE/ | 101,926 | 760,000 | 0.35% | ||
| 43 | TUDOR INVESTMENT CORP ET AL | 94,600 | 706,000 | 0.32% | ||
| 44 | TWO SIGMA ADVISERS, LP | 85,400 | 637,000 | 0.29% | ||
| 45 | SIMPLEX TRADING, LLC | 83,235 | 620,000 | 0.28% | ||
| 46 | SABBY MANAGEMENT, LLC | 81,185 | 606,000 | 0.28% | ||
| 47 | BANK OF AMERICA CORP /DE/ | 80,000 | 597,000 | 0.27% | Call | |
| 48 | PUTNAM INVESTMENTS LLC | 75,000 | 560,000 | 0.26% | ||
| 49 | JANE STREET GROUP, LLC | 72,300 | 539,000 | 0.25% | Put | |
| 50 | MACQUARIE GROUP LTD | 70,925 | 529,000 | 0.24% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
