| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 3,107,434 | 147,417,000 | 11.21% | ||
| 2 | WELLINGTON MANAGEMENT GROUP LLP | 2,651,113 | 125,769,000 | 9.57% | ||
| 3 | BB BIOTECH AG | 1,507,114 | 71,497,000 | 5.44% | ||
| 4 | VANGUARD GROUP INC | 1,464,152 | 69,460,000 | 5.28% | ||
| 5 | STATE STREET CORP | 1,359,796 | 64,523,000 | 4.91% | ||
| 6 | BlackRock Fund Advisors | 1,327,405 | 62,972,000 | 4.79% | ||
| 7 | JENNISON ASSOCIATES LLC | 1,122,818 | 53,266,000 | 4.05% | ||
| 8 | ALLIANCEBERNSTEIN L.P. | 1,059,196 | 50,248,000 | 3.82% | ||
| 9 | SECTORAL ASSET MANAGEMENT INC | 893,076 | 42,368,000 | 3.22% | ||
| 10 | BlackRock Institutional Trust Company, N.A. | 761,828 | 36,141,000 | 2.75% | ||
| 11 | Granahan Investment Management, LLC | 705,601 | 33,474,000 | 2.55% | ||
| 12 | Point72 Asset Management, L.P. | 626,243 | 29,709,000 | 2.26% | ||
| 13 | C WorldWide Group Holding A/S | 492,000 | 23,340,000 | 1.78% | ||
| 14 | Polar Capital LLP | 482,895 | 22,909,000 | 1.74% | ||
| 15 | BLACKROCK ADVISORS LLC | 449,948 | 21,346,000 | 1.62% | ||
| 16 | VOYA INVESTMENT MANAGEMENT LLC | 434,454 | 20,610,000 | 1.57% | ||
| 17 | COMMERZBANK AKTIENGESELLSCHAFT /FI | 429,532 | 20,377,000 | 1.55% | ||
| 18 | COLUMBIA PARTNERS L.L.C. INVESTMENT MANAGEMENT | 390,294 | 18,515,000 | 1.41% | ||
| 19 | CITADEL ADVISORS LLC | 383,128 | 18,176,000 | 1.38% | ||
| 20 | NORTHERN TRUST CORP | 360,968 | 17,124,000 | 1.30% | ||
| 21 | LOOMIS SAYLES & CO L P | 359,851 | 17,071,000 | 1.30% | ||
| 22 | FARALLON CAPITAL MANAGEMENT LLC | 348,000 | 16,509,000 | 1.26% | ||
| 23 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 300,000 | 14,232,000 | 1.08% | ||
| 24 | MILLENNIUM MANAGEMENT LLC | 297,175 | 14,098,000 | 1.07% | ||
| 25 | HARVEY CAPITAL MANAGEMENT INC | 293,675 | 14,061,000 | 1.07% | ||
| 26 | EVENTIDE ASSET MANAGEMENT, LLC | 290,000 | 13,758,000 | 1.05% | ||
| 27 | OppenheimerFunds, Inc. | 246,450 | 11,692,000 | 0.89% | ||
| 28 | Bank of New York Mellon Corp | 230,528 | 10,937,000 | 0.83% | ||
| 29 | WELLS FARGO & COMPANY/MN | 229,396 | 10,882,000 | 0.83% | ||
| 30 | GEODE CAPITAL MANAGEMENT, LLC | 226,850 | 10,761,000 | 0.82% | ||
| 31 | AXA S.A. | 198,511 | 9,417,000 | 0.72% | ||
| 32 | CQS Cayman LP | 190,000 | 9,014,000 | 0.69% | ||
| 33 | BANK OF MONTREAL /CAN/ | 176,607 | 8,378,000 | 0.64% | ||
| 34 | FRED ALGER MANAGEMENT, LLC | 160,201 | 7,600,000 | 0.58% | ||
| 35 | TIAA CREF INVESTMENT MANAGEMENT LLC | 157,135 | 7,454,000 | 0.57% | ||
| 36 | GRATICULE ASIA MACRO ADVISORS LLC | 152,788 | 7,247,000 | 0.55% | ||
| 37 | BlackRock Investment Management, LLC | 150,725 | 7,150,000 | 0.54% | ||
| 38 | DRIEHAUS CAPITAL MANAGEMENT LLC | 148,637 | 7,051,000 | 0.54% | ||
| 39 | Allianz Asset Management GmbH | 147,608 | 7,003,000 | 0.53% | ||
| 40 | GABELLI FUNDS LLC | 146,000 | 6,926,000 | 0.53% | ||
| 41 | Candriam S.C.A. | 143,000 | 6,784,000 | 0.52% | ||
| 42 | UNITED SERVICES AUTOMOBILE ASSOCIATION | 140,077 | 6,645,000 | 0.51% | ||
| 43 | AQR CAPITAL MANAGEMENT LLC | 128,462 | 6,095,000 | 0.46% | ||
| 44 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 113,600 | 5,389,000 | 0.41% | Put | |
| 45 | PALISADE CAPITAL MANAGEMENT, LP | 109,995 | 5,218,000 | 0.40% | ||
| 46 | Rhenman & Partners Asset Management AB | 107,400 | 5,095,000 | 0.39% | ||
| 47 | PERCEPTIVE ADVISORS LLC | 100,000 | 4,744,000 | 0.36% | ||
| 48 | Informed Momentum Co LLC | 94,321 | 4,475,000 | 0.34% | ||
| 49 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 88,441 | 4,196,000 | 0.32% | ||
| 50 | MILLENNIUM MANAGEMENT LLC | 81,000 | 3,843,000 | 0.29% | Call |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
