| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | GREAT POINT PARTNERS LLC | 3,653,200 | 16,914,000 | 15.24% | ||
| 2 | CANADA PENSION PLAN INVESTMENT BOARD | 1,976,220 | 9,150,000 | 8.24% | ||
| 3 | FMR LLC | 1,968,634 | 9,115,000 | 8.21% | ||
| 4 | VANGUARD GROUP INC | 1,595,691 | 7,388,000 | 6.66% | ||
| 5 | BlackRock Fund Advisors | 1,336,411 | 6,188,000 | 5.57% | ||
| 6 | WELLINGTON MANAGEMENT GROUP LLP | 1,240,801 | 5,745,000 | 5.18% | ||
| 7 | RENAISSANCE TECHNOLOGIES LLC | 979,200 | 4,534,000 | 4.08% | ||
| 8 | BlackRock Institutional Trust Company, N.A. | 920,408 | 4,261,000 | 3.84% | ||
| 9 | Numeric Investors LLC | 892,482 | 4,132,000 | 3.72% | ||
| 10 | MILLENNIUM MANAGEMENT LLC | 808,720 | 3,744,000 | 3.37% | ||
| 11 | STATE STREET CORP | 691,905 | 3,206,000 | 2.89% | ||
| 12 | Granahan Investment Management, LLC | 568,001 | 2,630,000 | 2.37% | ||
| 13 | C WorldWide Group Holding A/S | 461,510 | 2,137,000 | 1.93% | ||
| 14 | NORTHERN TRUST CORP | 422,152 | 1,954,000 | 1.76% | ||
| 15 | Clearline Capital LP | 417,582 | 1,933,000 | 1.74% | ||
| 16 | Rock Springs Capital Management LP | 400,000 | 1,852,000 | 1.67% | ||
| 17 | DEUTSCHE BANK AG\ | 328,468 | 1,518,000 | 1.37% | ||
| 18 | Sculptor Capital LP | 322,900 | 1,496,000 | 1.35% | Call | |
| 19 | Rhenman & Partners Asset Management AB | 300,000 | 1,389,000 | 1.25% | ||
| 20 | Gruss Capital Management LP | 300,000 | 1,389,000 | 1.25% | ||
| 21 | Candriam S.C.A. | 284,000 | 1,308,000 | 1.18% | ||
| 22 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 260,300 | 1,205,000 | 1.09% | ||
| 23 | GEODE CAPITAL MANAGEMENT, LLC | 233,255 | 1,079,000 | 0.97% | ||
| 24 | Bank of New York Mellon Corp | 202,667 | 938,000 | 0.85% | ||
| 25 | Tekla Capital Management LLC | 192,322 | 890,000 | 0.80% | ||
| 26 | TIAA CREF INVESTMENT MANAGEMENT LLC | 181,136 | 839,000 | 0.76% | ||
| 27 | TWO SIGMA INVESTMENTS, LP | 153,179 | 709,000 | 0.64% | ||
| 28 | TFS CAPITAL LLC | 152,502 | 706,000 | 0.64% | ||
| 29 | PANAGORA ASSET MANAGEMENT INC | 127,930 | 592,000 | 0.53% | ||
| 30 | BlackRock Investment Management, LLC | 123,353 | 571,000 | 0.51% | ||
| 31 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 113,911 | 527,000 | 0.47% | ||
| 32 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 111,605 | 517,000 | 0.47% | ||
| 33 | GOLDMAN SACHS GROUP INC | 109,193 | 506,000 | 0.46% | ||
| 34 | TEACHERS ADVISORS, LLC | 107,573 | 498,000 | 0.45% | ||
| 35 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 104,000 | 482,000 | 0.43% | Put | |
| 36 | TWO SIGMA ADVISERS, LP | 102,500 | 475,000 | 0.43% | ||
| 37 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 76,520 | 354,000 | 0.32% | ||
| 38 | FALCON POINT CAPITAL, LLC | 76,259 | 353,000 | 0.32% | ||
| 39 | PUTNAM INVESTMENTS LLC | 75,000 | 347,000 | 0.31% | ||
| 40 | GROUP ONE TRADING LLC | 74,840 | 347,000 | 0.31% | ||
| 41 | RUSSELL FRANK CO/ | 67,976 | 315,000 | 0.28% | ||
| 42 | UNITED SERVICES AUTOMOBILE ASSOCIATION | 65,791 | 305,000 | 0.27% | ||
| 43 | DOW CHEMICAL CO /DE/ | 65,000 | 301,000 | 0.27% | ||
| 44 | NumerixS Investment Technologies Inc | 62,443 | 289,000 | 0.26% | ||
| 45 | GABELLI FUNDS LLC | 59,000 | 273,000 | 0.25% | ||
| 46 | Squarepoint Ops LLC | 58,931 | 273,000 | 0.25% | ||
| 47 | CREDIT SUISSE AG/ | 58,482 | 271,000 | 0.24% | ||
| 48 | MORGAN STANLEY | 55,633 | 257,000 | 0.23% | ||
| 49 | ALLIANCEBERNSTEIN L.P. | 46,040 | 213,000 | 0.19% | ||
| 50 | AQR CAPITAL MANAGEMENT LLC | 45,279 | 210,000 | 0.19% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
